Results 201 to 210 of about 40,214 (287)

The interaction between polygenic risk score and trauma affects the likelihood of post-traumatic stress disorder in female victims of sexual assault [PDF]

Amanda Bugiga, Carolina Muniz Carvalho, Adrielle Martins Oliveira, Bruno Messina Coimbra, Samar Nasser Chehimi, Évelin Aline Zanardo, Leslie Domenici Kulikowski, Andréa F. Mello, Vanessa Ota, Marcelo F. Mello, Síntia Belangero   +10 more
openalex   +1 more source

Meta‐analysis of genetic mapping studies in mice reveals candidate epilepsy modifier genes that are outside the current drug development landscape

Epilepsia, EarlyView.
Abstract Objective Despite decades of development in anti‐seizure medications, ~30% of individuals remain refractory to all treatments, and none of the existing therapies are disease modifying. Identifying targets outside the current preclinical paradigm is critically important.
Giovanna L. Durante, Anna L. Tyler, Rod C. Scott, Amanda E. Hernan, J. Matthew Mahoney   +4 more
wiley   +1 more source

Polygenic score from MODY genes is associated with type 1 diabetes and disease characteristics. [PDF]

Acta Diabetol
Catamo E, Conti A, Franceschi R, Dovc K, Morosini C, Tinti D, Aldegheri L, Cappellani S, Tamaro G, Zanfardino A, Faleschini E, Rabbone I, Bonfanti R, Battelino T, Iafusco D, Tornese G, Robino A.   +16 more
europepmc   +1 more source

Conditional deletion of the multiple sclerosis susceptibility gene ATXN1 identifies cell‐autonomous effects in the B‐cell compartment

The FEBS Journal, EarlyView.
Ataxin‐1 is a polyglutamine protein associated with the etiology of spinocerebellar ataxia type 1 (SCA1) that has been recently found implicated in the risk of developing the autoimmune disorder multiple sclerosis (MS). Here, we took a conditional knockout approach to ablate ataxin‐1 exclusively in the B‐cell compartment and we found that this protein ...
Jonathan Jacob Carver, Rachael Riley Denbrock, Cindy Carolina Martines, Alessandro Didonna   +3 more
wiley   +1 more source

Specificity of polygenic scores for psychiatric disorders beyond transdiagnostic genetic risk (p) [PDF]

Engin Keser, Wangjingyi Liao, Andrea G. Allegrini, Thalia C. Eley, Kaili Rimfeld, Margherita Malanchini, Robert Plomin   +6 more
openalex   +1 more source

Comparative analysis of metabolic and functional cardiac alterations in diet‐ and genetically induced mouse models of cardiac dysfunction

The FEBS Journal, EarlyView.
Dietary and genetic stress trigger different routes to heart failure. In mice, a carbohydrate‐free high‐fat diet caused mitochondrial dysfunction and impaired energy production with preserved pumping function, while genetic obesity led to heart enlargement, fibrosis, and reduced function.
Christiane Ott, Patricia Baumgarten, Thorsten Henning, Daniela Weber, Iwona Wallach, Jana Grune, Ulrich Kintscher, Hermann‐Georg Holzhütter, Tilman Grune, Nikolaus Berndt   +9 more
wiley   +1 more source

Polygenic Score Approach to Predicting Risk of Metabolic Syndrome. [PDF]

Genes (Basel)
Timasheva Y, Kochetova O, Balkhiyarova Z, Korytina G, Prokopenko I, Nouwen A.   +5 more
europepmc   +1 more source

Improving Melanoma Risk Stratification of Skin Color Type by Polygenic Scores of Skin Color and Melanoma

International Journal of Dermatology, EarlyView.
ABSTRACT Background The Fitzpatrick skin type (FST) is commonly used in clinical settings to stratify melanoma risk across different skin types. However, it is subjective and does not capture intra‐type variability in risk. These limitations are particularly evident among lighter‐skinned individuals, who constitute the majority of those with European ...
Huy Tran, Annabelle Ashworth, Zhuqing Shi, Jun Wei, S. Lilly Zheng, Ross M. Levy, Luzheng Liu, David Duggan, Aleksandar Sekulic, Jianfeng Xu   +9 more
wiley   +1 more source

Polygenic Score Complements Family History and Lynch Syndrome Genes for Predicting Colorectal Cancer Risk. [PDF]

JCO Precis Oncol
Helfand TY, Wei J, Mulford AJ, Tran H, Shi Z, Wang CH, Rifkin AS, Ashworth A, Zheng SL, Helfand BT, Dunnenberger HM, Duggan D, Hulick PJ, DePersia A, Sanders AR, Xu J.   +15 more
europepmc   +1 more source

Association of clonal haematopoiesis and diabetes with outcomes after autologous haematopoietic cell transplantation

Diabetes, Obesity and Metabolism, EarlyView.
Rusha Bhandari, June‐Wha Rhee, Sitong Chen, Raju Pillai, Alysia Bosworth, Artem Oganesyan, Liezl Atencio, Caitlyn Estrada, Mareen Kassabian, Lanie Lindenfeld, Scott Goldsmith, Michael Rosenzweig, Alex F. Herrera, Matthew G. Mei, Ryotaro Nakamura, Rama Natarajan, F. Lennie Wong, Stephen J. Forman, Saro H. Armenian   +18 more
wiley   +1 more source