Brain Imaging Phenotypes Associated with Polygenic Risk for Essential Tremor
Movement Disorders, EarlyView.Abstract Essential tremor (ET) is a common movement disorder with a strong genetic basis. Magnetic resonance imaging (MRI), particularly diffusion‐weighted MRI (dMRI) and T1 MRI, have been used to identify brain abnormalities of ET patients. However, the mechanisms by which genetic risk affects the brain to render individuals vulnerable to ET remain ...
Miranda Medeiros +14 more
wiley +1 more source
Treatment Selection and Prioritization for the EJS ACT‐PD MAMS Trial Platform
Movement Disorders, EarlyView.Abstract Background There are currently no disease‐modifying therapies (DMTs) registered for Parkinson's disease (PD). The Edmond J. Safra Accelerating Clinical Trials in Parkinson Disease (EJS ACT‐PD) initiative will expedite clinical assessment of putative DMTs through a multi‐arm multistage (MAMS) trial, testing several treatments against a common ...
Cristina Gonzalez‐Robles +29 more
wiley +1 more source
131. Polygenic Risk Profile Scores Predict Cognitive Performance in Many Schizophrenia Cases but for Individuals With a Large Premorbid/Current IQ Difference, They Don’t [PDF]
, 2017 Dwight Dickinson +4 more
openalex +1 more source
Genetic Risk Factors in Normal Pressure Hydrocephalus: What We Know and What Is Next
Movement Disorders, EarlyView.Abstract Knowledge of the genetic factors in normal pressure hydrocephalus (NPH) is rapidly evolving, with significant advances in recent years. We conducted a systematic review examining genetic contributions to NPH risk. Ovid Embase, Ovid Medline, Web of Science, and Cochrane Central were searched from inception through October 14, 2024, for human ...
Camila C. Piccinin +9 more
wiley +1 more source
Genetics of drug‐induced liver injury: Current knowledge and future prospects
Clinical and Translational Science, Volume 16, Issue 1, Page 37-42, January 2023., 2023 Abstract Idiosyncratic drug‐induced liver injury (DILI) remains an important clinical problem, both during drug development and the prescription of a range of licensed drugs. Although rare, the consequences are serious. Ongoing studies on genetic risk factors for DILI, especially genomewide association studies, have resulted in the identification of a ...
Ann K. Daly
wiley +1 more source
Just-DNA-Seq, open-source personal genomics platform: longevity science for everyone [PDF]
arXivGenomic data has become increasingly accessible to the general public with the advent of companies offering whole genome sequencing at a relatively low cost. However, their reports are not verifiable due to a lack of crucial details and transparency: polygenic risk scores do not always mention all the polymorphisms involved.
arxiv
Spina bifida as a multifactorial birth defect: Risk factors and genetic underpinnings
Pediatric Discovery, EarlyView.Abstract Spina bifida is a birth defect resulting from abnormal embryonic development of the neural tube. Though spina bifida is divided into several subtypes, myelomeningocele—the most severe form of spina bifida often associated with a markedly diminished quality of life—accounts for a significant portion of cases.
Ethan S. Wong +13 more
wiley +1 more source
Research Highlights, The Plant Genome, Volume 15, Issue 4
, 2022 The Plant Genome, Volume 15, Issue 4, December 2022.
wiley +1 more source
A Polygenic Score for Higher Educational Attainment is Associated with Larger Brains [PDF]
, 2018 Maxwell L. Elliott +14 more
openalex +1 more source