Results 201 to 210 of about 3,197,012 (359)

Polygenic risk scores and Parkinson’s disease in South Africa: Moving towards ancestry-informed disease prediction [PDF]

Kathryn Step, Carene Anne Alene Ndong Sima, Spencer Grant, Jonggeol Jeffrey Kim, Emily Waldo, Soraya Bardien, Ignácio F. Mata   +6 more
openalex   +1 more source

Somatic mutational profiles and germline polygenic risk scores in human cancer [PDF]

, 2021
Yuxi Liu, Alexander Gusev, Yujing J. Heng, Ludmil B. Alexandrov, Peter Kraft   +4 more
openalex   +1 more source

Polygenic risk scores and rheumatic diseases

Chinese Medical Journal, 2021
Matthew A. Brown, Zhixiu Li, Li-Shao Guo
openaire   +4 more sources

A Genome‐Wide Association Study of Colorectal Cancer Mortality Outcomes Among Individuals of African and Admixture Ancestry

Molecular Carcinogenesis, EarlyView.
ABSTRACT African Americans have the highest colorectal cancer (CRC) mortality rates in the United States. We performed the first genome‐wide association study (GWAS) of overall and CRC‐specific mortality among African Americans with incident CRC to identify genetic contributors to CRC outcomes.
Thomas Lawler, Jirong Long, Rene Welch, Irene Ong, Oluwatoyosi Ogunmuyiwa, Rida A. Khatri, Martha Shrubsole, Shaneda Warren Andersen   +7 more
wiley   +1 more source

Polygenic Risk Score in Africa Population: Progress and challenges [PDF]

, 2021
Yagoub Adam, Suraju Sadeeq, Judit Kumuthini, Olabode Ajayi, Gordon Wells, Solomon O. Rotimi, Olubanke Olujoke Ogunlana, Emmanuel Adetiba, Emeka Iweala, Benedikt Brors, Ezekiel Adebiyi   +10 more
openalex   +1 more source

Movement Disorders Associated with 22q11.2 Microdeletion: A Scoping Review

Movement Disorders Clinical Practice, EarlyView.
Abstract Background Movement disorders have recently emerged as important neurologic manifestations of the 22q11.2 microdeletion that affects nearly one in every 2000 live births. Objective We aimed to map the existing evidence regarding the spectrum, diagnosis and treatment, and etiopathogenesis of movement disorders associated with 22q11.2 ...
Nikolai Gil D. Reyes, Daniel G. Di Luca, Connie Marras, Erik Boot, Ryan K.C. Yuen, Anthony E. Lang, Anne S. Bassett   +6 more
wiley   +1 more source

Genetic and Pathological Testing Attitudes for Parkinson's Disease in At‐Risk Relatives

Movement Disorders Clinical Practice, EarlyView.
Abstract Background Parkinson's disease (PD) is increasingly recognized as a neurodegenerative disorder with a broad clinical spectrum and diverse biomarkers enabling early detection. α‐synuclein seed amplification assays (SAA) and genetic testing now allow identification of PD pathology in asymptomatic individuals.
Tal Weil, Anat Mirelman, Roy N. Alcalay, Nurit Omer, Penina Ponger, Avner Thaler   +5 more
wiley   +1 more source

Statistical genetics and polygenic risk score for precision medicine [PDF]

, 2021
Takahiro Konuma, Yukinori Okada
openalex   +1 more source

LRRK2 as a Potential Disease‐Modifying Target in Sporadic Parkinson's Disease

Movement Disorders, EarlyView.
Abstract A growing understanding of the role that leucine‐rich repeat kinase 2 (LRRK2) plays in Parkinson's disease (PD) supports continued focus on this enzyme as a therapeutic target for PD. Accumulating evidence suggests that there are phenotypic, neuropathologic, and biological similarities between sporadic PD (sPD) and familial forms in which ...
Anthony E. Lang, Robert A. Hauser, Lorraine V. Kalia, Bonnie Hersh, Zdenek Berger, Roy Llorens Arenas, Coro Paisan‐Ruiz, Kyle Fraser, Danna Jennings, Jillian H. Kluss, Sarah Huntwork‐Rodriguez, Anastasia G. Henry, J. Timothy Greenamyre   +12 more
wiley   +1 more source

Utility of polygenic scores across diverse diseases in a hospital cohort for predictive modeling

Nature Communications
Polygenic scores estimate genetic susceptibility to diseases. We systematically calculated polygenic scores across 457 phenotypes using genotyping array data from China Medical University Hospital.
Ting-Hsuan Sun, Chia-Chun Wang, Ting-Yuan Liu, Shih-Chang Lo, Yi-Xuan Huang, Shang-Yu Chien, Yu-De Chu, Fuu-Jen Tsai, Kai-Cheng Hsu   +8 more
doaj   +1 more source