Results 21 to 30 of about 2,929,620 (353)

Headaches and polygenic scores [PDF]

Neurology Genetics, 2019
Polygenic risk scores are en vogue. This ubiquitous statistic quantifies disease liability for an individual by aggregating risk contributions from a large number of genetic variants into a single score. Recent publications have argued that risk models currently used in clinical settings for coronary artery disease can be improved by including ...
Vilhjálmsson, Bjarni Jóhann, Privé, Florian Franck   +1 more
openaire   +3 more sources

Evaluation of polygenic prediction methodology within a reference-standardized framework.

PLoS Genetics, 2021
The predictive utility of polygenic scores is increasing, and many polygenic scoring methods are available, but it is unclear which method performs best.
Oliver Pain, Kylie P Glanville, Saskia P Hagenaars, Saskia Selzam, Anna E Fürtjes, Héléna A Gaspar, Jonathan R I Coleman, Kaili Rimfeld, Gerome Breen, Robert Plomin, Lasse Folkersen, Cathryn M Lewis   +11 more
doaj   +1 more source

Polygenic Scores for Height in Admixed Populations [PDF]

G3 Genes|Genomes|Genetics, 2020
AbstractPolygenic risk scores (PRS) use the results of genome-wide association studies (GWAS) to predict quantitative phenotypes or disease risk at an individual level, and provide a potential route to the use of genetic data in personalized medical care.
Bitarello, Bárbara D., Mathieson, Iain
openaire   +5 more sources

Calculating Polygenic Risk Scores (PRS) in UK Biobank: A Practical Guide for Epidemiologists

Frontiers in Genetics, 2022
A polygenic risk score estimates the genetic risk of an individual for some disease or trait, calculated by aggregating the effect of many common variants associated with the condition.
Jennifer A. Collister, Xiaonan Liu, Lei Clifton   +2 more
doaj   +1 more source

Polygenic scores and social science

Behavioral and Brain Sciences, 2023
Abstract It is a hotly contested issue whether polygenic scores should play a major role in the social sciences. Here, we defend a methodologically pluralist stance in which sociogenomics should abandon its hype and recognize that it suffers from all the methodological difficulties of the social sciences, yet nevertheless maintain an optimistic ...
Walter Veit, Heather Browning
openaire   +4 more sources

Polygenic Risk Scores and Physical Activity [PDF]

Medicine & Science in Sports & Exercise, 2020
ABSTRACT Purpose Polygenic risk scores (PRS) summarize genome-wide genotype data into a single variable that produces an individual-level risk score for genetic liability. PRS has been used for prediction of chronic diseases and some risk factors. As PRS has been studied less for physical activity (PA), we constructed
Kujala, Urho M., Palviainen, Teemu, Pesonen, Paula, Waller, Katja, Sillanpää, Elina, Niemelä, Maisa, Kangas, Maarit, Vähä-Ypyä, Henri, Sievänen, Harri, Korpelainen, Raija, Jämsä, Timo, Männikkö, Minna, Kaprio, Jaakko   +13 more
openaire   +7 more sources

Using a Polygenic Score to Predict the Risk of Developing Primary Osteoporosis

International Journal of Molecular Sciences, 2022
Osteoporosis (OP) is a multifactorial bone disease belonging to the metabolic osteopathies group. Using the polygenic score (PGS) approach, we combined the effects of bone mineral density (BMD) DNA loci, affecting osteoporosis pathogenesis, based on ...
B. Yalaev, A. Tyurin, I. Prokopenko, A. Karunas, E. Khusnutdinova, R. Khusainova   +5 more
semanticscholar   +1 more source

Copy number variants suggest different molecular pathways for the pathogenesis of bladder exstrophy

American Journal of Medical Genetics Part A, Volume 191, Issue 2, Page 378-390, February 2023., 2023
Abstract Bladder exstrophy is a rare congenital malformation leaving the urinary bladder open in the midline of the abdomen at birth. There is a clear genetic background with chromosome aberrations, but so far, no consistent findings apart from 22q11‐duplications detected in about 2%–3% of all patients.
Agneta Nordenskjöld, Samara Arkani, Maria Pettersson, Johanna Winberg, Jia Cao, Magdalena Fossum, Magnus Anderberg, Gillian Barker, Gundela Holmdahl, Johanna Lundin   +9 more
wiley   +1 more source

Multivariate analyses of molecular genetic associations between childhood psychopathology and adult mood disorders and related traits

American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, Volume 192, Issue 1-2, Page 3-12, January-March 2023., 2023
Abstract Ubiquitous associations have been detected between different types of childhood psychopathology and polygenic risk scores based on adult psychiatric disorders and related adult outcomes, indicating that genetic factors partly explain the association between childhood psychopathology and adult outcomes. However, these analyses in general do not
Wonuola A. Akingbuwa, Anke R. Hammerschlag, Andrea G. Allegrini, Hannah Sallis, Ralf Kuja‐Halkola, Kaili Rimfeld, Paul Lichtenstein, Sebastian Lundstrom, Marcus R. Munafò, Robert Plomin, Michel G. Nivard, Meike Bartels, Christel M. Middeldorp   +12 more
wiley   +1 more source

Polygenic Risk Scores for Subtyping of Schizophrenia [PDF]

Schizophrenia Research and Treatment, 2020
Schizophrenia is a complex disorder with many comorbid conditions. In this study, we used polygenic risk scores (PRSs) from schizophrenia and comorbid traits to explore consistent cluster structure in schizophrenia patients. With 10 comorbid traits, we found a stable 4-cluster structure in two datasets (MGS and SSCCS).
Jingchun Chen, Travis Mize, Jain-Shing Wu, Elliot Hong, Vishwajit Nimgaonkar, Kenneth S. Kendler, Daniel Allen, Edwin Oh, Alison Netski, Xiangning Chen   +9 more
openaire   +3 more sources