Results 21 to 30 of about 40,214 (287)

Twelve Variants Polygenic Score for Low‐Density Lipoprotein Cholesterol Distribution in a Large Cohort of Patients With Clinically Diagnosed Familial Hypercholesterolemia With or Without Causative Mutations

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2022
Background A significant proportion of individuals clinically diagnosed with familial hypercholesterolemia (FH), but without any disease‐causing mutation, are likely to have polygenic hypercholesterolemia.
Elena Olmastroni, Marta Gazzotti, Marcello Arca, Maurizio Averna, Angela Pirillo, Alberico Luigi Catapano, Manuela Casula   +6 more
doaj   +1 more source

Identifying individuals with high risk of Alzheimer’s disease using polygenic risk scores

Nature Communications, 2021
While polygenic risk scores have been shown to be correlated with disease risk, there is little agreement on how the score should be calculated. Here the authors investigate risk scores for Alzheimer’s disease, finding that the most effective approach ...
Ganna Leonenko, Emily Baker, Joshua Stevenson-Hoare, Annerieke Sierksma, Mark Fiers, Julie Williams, Bart de Strooper, Valentina Escott-Price   +7 more
doaj   +1 more source

Association of Joint Genetic and Social Environmental Risks With Incident Myocardial Infarction: Results From the Health and Retirement Study

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2023
Background Myocardial infarction (MI) is a significant clinical and public health problem worldwide. However, little research has assessed the interplay between genetic susceptibility and social environment in the development of MI.
Junhan Tang, Chen Sheng, Yan Yan Wu, Lijing L. Yan, Chenkai Wu   +4 more
doaj   +1 more source

Polygenic risk score: use in migraine research

The Journal of Headache and Pain, 2018
Background The latest Genome-Wide Association Study identified 38 genetic variants associated with migraine. In this type of studies the significance level is very difficult to achieve (5 × 10− 8) due to multiple testing.
Mona Ameri Chalmer, Ann-Louise Esserlind, Jes Olesen, Thomas Folkmann Hansen   +3 more
doaj   +1 more source

Polygenic risk score improves the accuracy of a clinical risk score for coronary artery disease

BMC Medicine, 2022
Background The value of polygenic risk scores (PRSs) towards improving guideline-recommended clinical risk models for coronary artery disease (CAD) prediction is controversial.
Austin King, Lang Wu, Hong-Wen Deng, Hui Shen, Chong Wu   +4 more
doaj   +1 more source

NAFLD‐related hepatocellular carcinoma: The growing challenge

Hepatology, EarlyView., 2022
Risk and protective factors for NAFLD‐related hepatocellular carcinoma Abstract Hepatocellular carcinoma (HCC) is a common cause of cancer‐related mortality and morbidity worldwide. With the obesity pandemic, NAFLD‐related HCC is contributing to the burden of disease exponentially.
Pir Ahmad Shah, Rashmee Patil, Stephen A. Harrison   +2 more
wiley   +1 more source

Interpreting polygenic scores, polygenic adaptation, and human phenotypic differences [PDF]

Evolution, Medicine, and Public Health, 2018
Abstract Recent analyses of polygenic scores have opened new discussions concerning the genetic basis and evolutionary significance of differences among populations in distributions of phenotypes. Here, we highlight limitations in research on polygenic scores, polygenic adaptation and population differences.
Rosenberg, Noah A, Edge, Michael D, Pritchard, Jonathan K, Feldman, Marcus W   +3 more
openaire   +2 more sources

Polygenic Risk Scores Augment Stroke Subtyping [PDF]

Neurology Genetics, 2021
To determine whether the polygenic risk score (PRS) derived from MEGASTROKE is associated with ischemic stroke (IS) and its subtypes in an independent tertiary health care system and to identify the PRS derived from gene sets of known biological pathways associated with IS.Controls (n = 19,806/7,484, age ≥69/79 years) and cases (n = 1,184/951 for ...
Jiang Li, Durgesh P. Chaudhary, Ayesha Khan, Christoph Griessenauer, David J. Carey, Ramin Zand, Vida Abedi   +6 more
openaire   +2 more sources

Polygenic risk scores

Seminars in Arthritis and Rheumatism
Polygenic risk scores (PRS) estimate an individual's genetic risk for a disease or trait compared to a matched population. For many rheumatic diseases PRS have been developed that have discriminatory capacity better than some widely used biomarkers, and in some cases are the most discriminatory tests available.
Brian T. Palmisano, Joshua W. Knowles
  +6 more sources

Can education be personalised using pupils’ genetic data?

eLife, 2020
The increasing predictive power of polygenic scores for education has led to their promotion by some as a potential tool for genetically informed policy. How accurately polygenic scores predict an individual pupil's educational performance conditional on
Tim T Morris, Neil M Davies, George Davey Smith   +2 more
doaj   +1 more source