Results 31 to 40 of about 3,197,012 (359)
Movement Disorders, 2023 A mitochondrial polygenic score (MGS) is composed of genes related to mitochondrial function and found to be associated with Parkinson's disease (PD) risk.
Theresa Lüth +13 more
semanticscholar +1 more source
Evaluating the Performance of the WHO International Reference Standard for Osteoporosis Diagnosis in Postmenopausal Women of Varied Polygenic Score and Race [PDF]
, 2020 Background: Whether the bone mineral density (BMD) T-score performs differently in osteoporosis classification in women of different genetic profiling and race background remains unclear.
Wu, Qing, Xiao, Xiangxue, Xu, Yingke
core +2 more sources
Polygenic scores and social science
Behavioral and Brain Sciences, 2023 Abstract It is a hotly contested issue whether polygenic scores should play a major role in the social sciences. Here, we defend a methodologically pluralist stance in which sociogenomics should abandon its hype and recognize that it suffers from all the methodological difficulties of the social sciences, yet nevertheless maintain an optimistic ...
Walter Veit, Heather Browning
openaire +4 more sources
Polygenic Risk Scores and Physical Activity [PDF]
Medicine & Science in Sports & Exercise, 2020 ABSTRACT Purpose Polygenic risk scores (PRS) summarize genome-wide genotype data into a single variable that produces an individual-level risk score for genetic liability. PRS has been used for prediction of chronic diseases and some risk factors. As PRS has been studied less for physical activity (PA), we constructed
Kujala, Urho M. +13 more
openaire +6 more sources
Alzheimer’s Research & Therapy, 2023 Background Genomic study of cognition decline while considering baseline cognition and lifestyle behaviors is scarce. We aimed to evaluate the impact of a polygenic score for general cognition on cognition decline rate, while considering baseline ...
Tingting Liu +10 more
doaj +1 more source
Using a polygenic score in a family design to understand genetic influences on musicality
Scientific Reports, 2022 To further our understanding of the genetics of musicality, we explored associations between a polygenic score for self-reported beat synchronization ability (PGSrhythm) and objectively measured rhythm discrimination, as well as other validated music ...
L. Wesseldijk +58 more
semanticscholar +1 more source
Germline genetic variation in prostate susceptibility does not predict outcomes in the chemoprevention trials PCPT and SELECT [PDF]
, 2020 Background The development of prostate cancer can be influenced by genetic and environmental factors. Numerous germline SNPs influence prostate cancer susceptibility.
Ahmed, M +7 more
core +2 more sources
Frontiers in Genetics, 2022 A substantial proportion of the adult United States population with type 2 diabetes (T2D) are undiagnosed, calling into question the comprehensiveness of current screening practices, which primarily rely on age, family history, and body mass index (BMI).
James R. Ashenhurst +11 more
semanticscholar +1 more source
Identifying individuals with high risk of Alzheimer’s disease using polygenic risk scores
Nature Communications, 2021 While polygenic risk scores have been shown to be correlated with disease risk, there is little agreement on how the score should be calculated. Here the authors investigate risk scores for Alzheimer’s disease, finding that the most effective approach ...
Ganna Leonenko +7 more
doaj +1 more source
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2023 Background Myocardial infarction (MI) is a significant clinical and public health problem worldwide. However, little research has assessed the interplay between genetic susceptibility and social environment in the development of MI.
Junhan Tang +4 more
doaj +1 more source