Results 61 to 70 of about 3,197,012 (359)
On cross-ancestry cancer polygenic risk scores [PDF]
PLOS Genetics, 2021 Polygenic risk scores (PRS) can provide useful information for personalized risk stratification and disease risk assessment, especially when combined with non-genetic risk factors. However, their construction depends on the availability of summary statistics from genome-wide association studies (GWAS) independent from the target sample.
Lars G. Fritsche +6 more
openaire +4 more sources
Nature Communications, 2022 Polygenic risk scores have potential to predict an individual’s risk of disease based on genetic markers. Here, the authors develop a polygenic risk score for hypertension and test it in a multi-ethnic cohort, finding that the score is associated with ...
Nuzulul Kurniansyah +37 more
doaj +1 more source
Hepatology, EarlyView., 2022 Hepatic APOF transcript levels correlate inversely with plasma TG and hepatic steatosis in humans. ApoF expression in mice promotes VLDL‐TG production and lipoprotein remnant clearance in mice. Abstract Background NAFLD affects nearly 25% of the global population. Cardiovascular disease (CVD) is the most common cause of death among patients with NAFLD,
Audrey Deprince +30 more
wiley +1 more source
Predictive impact of rare genomic copy number variations in siblings of individuals with autism spectrum disorders. [PDF]
, 2019 Identification of genetic biomarkers associated with autism spectrum disorders (ASDs) could improve recurrence prediction for families with a child with ASD.
Brian, J +21 more
core +2 more sources
BMC Medical Genomics, 2020 Background Polygenic scores are a strategy to aggregate the small, additive effects of single nucleotide polymorphisms across the genome. With phenotypes like Alzheimer’s disease, which have a strong and well-established genomic locus (APOE), the ...
Erin B. Ware +3 more
doaj +1 more source
Polygenic risk scores in epilepsy
Medizinische Genetik, 2022 Abstract An epilepsy diagnosis has large consequences for an individual but is often difficult to make in clinical practice. Novel biomarkers are thus greatly needed. Here, we give an overview of how thousands of common genetic factors that increase the risk for epilepsy can be summarized as epilepsy polygenic risk scores (PRS).
openaire +3 more sources
Geographic Clustering of Polygenic Scores at Different Stages of the Life Course
RSF: The Russell Sage Foundation Journal of the Social Sciences, 2018 We interrogate state-level clustering of polygenic scores at different points in the life course and variation in the association of mean polygenic scores in a respondent’s state of birth with corresponding phenotypes. The polygenic scores for height and
Benjamin W. Domingue +3 more
doaj +1 more source
Genetic predisposition, Aβ misfolding in blood plasma, and Alzheimer’s disease
Translational Psychiatry, 2021 Alzheimer’s disease is highly heritable and characterized by amyloid plaques and tau tangles in the brain. The aim of this study was to investigate the association between genetic predisposition, Aβ misfolding in blood plasma, a unique marker of ...
Hannah Stocker +10 more
doaj +1 more source
Neurocognitive trajectory and proteomic signature of inherited risk for Alzheimer's disease.
PLoS Genetics, 2022 For Alzheimer's disease-a leading cause of dementia and global morbidity-improved identification of presymptomatic high-risk individuals and identification of new circulating biomarkers are key public health needs.
Manish D Paranjpe +15 more
doaj +1 more source
Single-nucleotide polymorphism-based genetic risk score and patient age at prostate cancer diagnosis [PDF]
, 2019 Importance: Few studies have evaluated the association between a single-nucleotide polymorphism-based genetic risk score (GRS) and patient age at prostate cancer (PCa) diagnosis.
Andriole, Gerald L +10 more
core +2 more sources