Results 61 to 70 of about 2,929,620 (353)

Privacy with Good Taste: A Case Study in Quantifying Privacy Risks in Genetic Scores [PDF]

arXiv, 2022
Analysis of genetic data opens up many opportunities for medical and scientific advances. The use of phenotypic information and polygenic risk scores to analyze genetic data is widespread. Most work on genetic privacy focuses on basic genetic data such as SNP values and specific genotypes. In this paper, we introduce a novel methodology to quantify and
arxiv  

Geographic Clustering of Polygenic Scores at Different Stages of the Life Course

RSF: The Russell Sage Foundation Journal of the Social Sciences, 2018
We interrogate state-level clustering of polygenic scores at different points in the life course and variation in the association of mean polygenic scores in a respondent’s state of birth with corresponding phenotypes. The polygenic scores for height and
Benjamin W. Domingue, David H. Rehkopf, Dalton Conley, Jason D. BOardman   +3 more
doaj   +1 more source

Genetic predisposition, Aβ misfolding in blood plasma, and Alzheimer’s disease

Translational Psychiatry, 2021
Alzheimer’s disease is highly heritable and characterized by amyloid plaques and tau tangles in the brain. The aim of this study was to investigate the association between genetic predisposition, Aβ misfolding in blood plasma, a unique marker of ...
Hannah Stocker, Andreas Nabers, Laura Perna, Tobias Möllers, Dan Rujescu, Annette M. Hartmann, Bernd Holleczek, Ben Schöttker, Julia Stockmann, Klaus Gerwert, Hermann Brenner   +10 more
doaj   +1 more source

Construction and Application of Polygenic Risk Scores in Autoimmune Diseases

Frontiers in Immunology, 2022
Genome-wide association studies (GWAS) have identified hundreds of genetic variants associated with autoimmune diseases and provided unique mechanistic insights and informed novel treatments.
Chachrit Khunsriraksakul, Chachrit Khunsriraksakul, Havell Markus, Havell Markus, Nancy J. Olsen, Laura Carrel, Bibo Jiang, Dajiang J. Liu, Dajiang J. Liu   +8 more
doaj   +1 more source

NAFLD‐related hepatocellular carcinoma: The growing challenge

Hepatology, EarlyView., 2022
Risk and protective factors for NAFLD‐related hepatocellular carcinoma Abstract Hepatocellular carcinoma (HCC) is a common cause of cancer‐related mortality and morbidity worldwide. With the obesity pandemic, NAFLD‐related HCC is contributing to the burden of disease exponentially.
Pir Ahmad Shah, Rashmee Patil, Stephen A. Harrison   +2 more
wiley   +1 more source

Performance of polygenic scores for predicting phobic anxiety. [PDF]

PLoS ONE, 2013
Anxiety disorders are common, with a lifetime prevalence of 20% in the U.S., and are responsible for substantial burdens of disability, missed work days and health care utilization.
Stefan Walter, M Maria Glymour, Karestan Koenen, Liming Liang, Eric J Tchetgen Tchetgen, Marilyn Cornelis, Shun-Chiao Chang, Eric Rimm, Ichiro Kawachi, Laura D Kubzansky   +9 more
doaj   +1 more source

Neurocognitive trajectory and proteomic signature of inherited risk for Alzheimer's disease.

PLoS Genetics, 2022
For Alzheimer's disease-a leading cause of dementia and global morbidity-improved identification of presymptomatic high-risk individuals and identification of new circulating biomarkers are key public health needs.
Manish D Paranjpe, Mark Chaffin, Sohail Zahid, Scott Ritchie, Jerome I Rotter, Stephen S Rich, Robert Gerszten, Xiuqing Guo, Susan Heckbert, Russ Tracy, John Danesh, Eric S Lander, Michael Inouye, Sekar Kathiresan, Adam S Butterworth, Amit V Khera   +15 more
doaj   +1 more source

From Genotype to Phenotype: polygenic prediction of complex human traits [PDF]

arXiv, 2021
Decoding the genome confers the capability to predict characteristics of the organism(phenotype) from DNA (genotype). We describe the present status and future prospects of genomic prediction of complex traits in humans. Some highly heritable complex phenotypes such as height and other quantitative traits can already be predicted with reasonable ...
arxiv  

Development of a clinical polygenic risk score assay and reporting workflow

Nature Network Boston, 2022
Implementation of polygenic risk scores (PRS) may improve disease prevention and management but poses several challenges: the construction of clinically valid assays, interpretation for individual patients, and the development of clinical workflows and ...
Limin Hao, P. Kraft, G. Berriz, Elizabeth D. Hynes, C. Koch, Prathik Korategere V Kumar, Shruti S Parpattedar, Marcie A. Steeves, Wanfeng Yu, Ashley A. Antwi, Charles A. Brunette, Morgan E. Danowski, M. Gala, Robert C. Green, Natalie E. Jones, A. Lewis, S. Lubitz, P. Natarajan, J. Vassy, Matthew S. Lebo   +19 more
semanticscholar   +1 more source

Apolipoprotein F is reduced in humans with steatosis and controls plasma triglyceride‐rich lipoprotein metabolism

Hepatology, EarlyView., 2022
Hepatic APOF transcript levels correlate inversely with plasma TG and hepatic steatosis in humans. ApoF expression in mice promotes VLDL‐TG production and lipoprotein remnant clearance in mice. Abstract Background NAFLD affects nearly 25% of the global population. Cardiovascular disease (CVD) is the most common cause of death among patients with NAFLD,
Audrey Deprince, Nathalie Hennuyer, Sander Kooijman, Amanda C. M. Pronk, Eric Baugé, Viktor Lienard, An Verrijken, Eveline Dirinck, Luisa Vonghia, Eloïse Woitrain, Niels J. Kloosterhuis, Eléonore Marez, Pauline Jacquemain, Justina C. Wolters, Fanny Lalloyer, Delphine Eberlé, Sandrine Quemener, Emmanuelle Vallez, Anne Tailleux, Mostafa Kouach, Jean‐Francois Goossens, Violeta Raverdy, Bruno Derudas, Jan Albert Kuivenhoven, Mikaël Croyal, Bart van de Sluis, Sven Francque, François Pattou, Patrick C. N. Rensen, Bart Staels, Joel T. Haas   +30 more
wiley   +1 more source