Results 71 to 80 of about 2,929,620 (353)
Translational Psychiatry, 2021 Changes in immune function are associated with variance in cognitive functioning in schizophrenia. Given that microglia are the primary innate immune cells in the brain, we examined whether schizophrenia risk-associated microglial genes (measured via ...
Emma Corley +5 more
doaj +1 more source
Genome Medicine, 2022 Type 2 diabetes (T2D) is a worldwide scourge caused by both genetic and environmental risk factors that disproportionately afflicts communities of color.
T. Ge +47 more
semanticscholar +1 more source
Making the most of Clumping and Thresholding for polygenic scores [PDF]
The American Journal of Human Genetics, 2019 AbstractPolygenic prediction has the potential to contribute to precision medicine. Clumping and Thresh-olding (C+T) is a widely used method to derive polygenic scores. When using C+T, it is common to test several p-value thresholds to maximize predictive ability of the derived polygenic scores.
Michael G. B. Blum +4 more
openaire +8 more sources
MicroRNA binding site variation is enriched in psychiatric disorders
Human Mutation, Volume 43, Issue 12, Page 2153-2169, December 2022., 2022 Abstract Psychiatric disorders have a polygenic architecture, often associated with dozens or hundreds of independent genomic loci. Most associated loci impact noncoding regions of the genome, suggesting that the majority of disease heritability originates from the disruption of regulatory sequences.
Michael P. Geaghan +2 more
wiley +1 more source
Life, 2020 Background: The monogenic defect in familial hypercholesterolemia (FH) is detected in ∼40% of cases. The majority of mutation-negative patients have a polygenic cause of high LDL-cholesterol (LDL-C).
Agnieszka Mickiewicz +11 more
doaj +1 more source
Transethnic Transferability of a Genome-wide Polygenic Score for Coronary Artery Disease.
Circulation Genomic and Precision Medicine, 2020 Genome-wide polygenic scores (GPSs) integrate information from millions of sites of common DNA variation into a single metric of inherited susceptibility.
A. Fahed +15 more
semanticscholar +1 more source
Human Mutation, Volume 43, Issue 12, Page 2234-2250, December 2022., 2022 Abstract Macular degenerations (MDs) are a subgroup of retinal disorders characterized by central vision loss. Knowledge is still lacking on the extent of genetic and nongenetic factors influencing inherited MD (iMD) and age‐related MD (AMD) expression.
Rebekkah J. Hitti‐Malin +15 more
wiley +1 more source
Genome-Wide Polygenic Score and the Risk of Ischemic Stroke in a Prospective Cohort
Stroke, 2020 Background and Purpose— Environmental and genetic factors contribute to the development of ischemic stroke (IS). We recently developed a genome-wide polygenic risk score (PRS) for IS using case-control datasets from 4 large-scale observational studies ...
Tsuyoshi Hachiya +7 more
semanticscholar +1 more source
Metrics for Evaluating Polygenic Risk Scores [PDF]
JNCI Cancer Spectrum, 2020 Abstract There is growing interest in the use of polygenic risk scores based on genetic variants to predict cancer incidence. The type of metric used to evaluate the predictive performance of polygenic risk scores plays a crucial role in their interpretation.
openaire +3 more sources
Polygenic transcriptome risk scores improve portability of polygenic risk scores across ancestries [PDF]
, 2020 AbstractPolygenic risk scores (PRS) are on course to translate the results of genome-wide association studies (GWAS) into clinical practice. To date, most GWAS have been based on individuals of European-ancestry, meaning that the utility of PRS for non-European populations is limited because SNP effects and LD patterns may not be conserved across ...
Yanyu Liang +6 more
openaire +2 more sources