Results 71 to 80 of about 3,197,012 (359)

The Polygenic Risk Score Knowledge Base offers a centralized online repository for calculating and contextualizing polygenic risk scores

Communications Biology, 2022
The Polygenic Risk Score Knowledge Base (PRSKB) is a web-based interface that stores data from >2,300 distinct genome-wide association studies, and can estimate polygenic risk scores for general use.
Madeline L. Page, Elizabeth L. Vance, Matthew E. Cloward, Ed Ringger, Louisa Dayton, Mark T. W. Ebbert, The Alzheimer’s Disease Neuroimaging Initiative, Justin B. Miller, John S. K. Kauwe   +8 more
doaj   +1 more source

Construction and Application of Polygenic Risk Scores in Autoimmune Diseases

Frontiers in Immunology, 2022
Genome-wide association studies (GWAS) have identified hundreds of genetic variants associated with autoimmune diseases and provided unique mechanistic insights and informed novel treatments.
Chachrit Khunsriraksakul, Chachrit Khunsriraksakul, Havell Markus, Havell Markus, Nancy J. Olsen, Laura Carrel, Bibo Jiang, Dajiang J. Liu, Dajiang J. Liu   +8 more
doaj   +1 more source

The Polygenic Score Catalog: an open database for reproducibility and systematic evaluation

medRxiv, 2020
Polygenic [risk] scores (PGS) can enhance prediction and understanding of common diseases and traits. However, the reproducibility of PGS and their subsequent applications in biological and clinical research have been hindered by several factors ...
Samuel A. Lambert, Laurent Gil, S. Jupp, S. Ritchie, Yu Xu, A. Buniello, Gad Abraham, Michael Chapman, H. Parkinson, J. Danesh, J. MacArthur, M. Inouye   +11 more
semanticscholar   +1 more source

Genome-Wide Polygenic Score, Clinical Risk Factors, and Long-Term Trajectories of Coronary Artery Disease

Arteriosclerosis, Thrombosis and Vascular Biology, 2020
Supplemental Digital Content is available in the text. Objective: To determine the relationship of a genome-wide polygenic score for coronary artery disease (GPSCAD) with lifetime trajectories of CAD risk, directly compare its predictive capacity to ...
G. Hindy, Krishna G. Aragam, Kenney Ng, M. Chaffin, L. Lotta, A. Baras, Isabel Drake, M. Orho-Melander, O. Melander, S. Kathiresan, A. Khera   +10 more
semanticscholar   +1 more source

Polygenic transcriptome risk scores improve portability of polygenic risk scores across ancestries [PDF]

, 2020
AbstractPolygenic risk scores (PRS) are on course to translate the results of genome-wide association studies (GWAS) into clinical practice. To date, most GWAS have been based on individuals of European-ancestry, meaning that the utility of PRS for non-European populations is limited because SNP effects and LD patterns may not be conserved across ...
Yanyu Liang, Milton Pividori, Ani Manichaikul, Abraham A. Palmer, Nancy J. Cox, Heather Wheeler, Hae Kyung Im   +6 more
openaire   +1 more source

Higher Responsiveness to Rosuvastatin in Polygenic versus Monogenic Hypercholesterolemia: A Propensity Score Analysis

Life, 2020
Background: The monogenic defect in familial hypercholesterolemia (FH) is detected in ∼40% of cases. The majority of mutation-negative patients have a polygenic cause of high LDL-cholesterol (LDL-C).
Agnieszka Mickiewicz, Marta Futema, Agnieszka Ćwiklinska, Agnieszka Kuchta, Maciej Jankowski, Mariusz Kaszubowski, Magdalena Chmara, Bartosz Wasąg, Marcin Fijałkowski, Miłosz Jaguszewski, Steve E. Humphries, Marcin Gruchała   +11 more
doaj   +1 more source

Microglial-expressed genetic risk variants, cognitive function and brain volume in patients with schizophrenia and healthy controls

Translational Psychiatry, 2021
Changes in immune function are associated with variance in cognitive functioning in schizophrenia. Given that microglia are the primary innate immune cells in the brain, we examined whether schizophrenia risk-associated microglial genes (measured via ...
Emma Corley, Laurena Holleran, Laura Fahey, Aiden Corvin, Derek W. Morris, Gary Donohoe   +5 more
doaj   +1 more source

Multi-Polygenic Risk Score Prediction Model for Bipolar Disorder

, 2019
Bipolar disorder (BP), a severe mental disorder characterized by recurring manic and depressive episodes, has been shown to have a strong genetic underpinning.
Mize, Travis
core   +1 more source

Polygenic Risk Scores Expand to Obesity [PDF]

Cell, 2019
Obesity is one of the most serious health challenges of our time. In this issue of Cell, Khera and co-authors demonstrate the striking ability of genetics, in the form of a polygenic risk score, to identify those individuals at high risk for obesity.
Ali, Torkamani, Eric, Topol
openaire   +2 more sources

Integrative polygenic risk score improves the prediction accuracy of complex traits and diseases

medRxiv, 2023
Polygenic risk scores (PRS) are an emerging tool to predict the clinical phenotypes and outcomes of individuals. Validation and transferability of existing PRS across independent datasets and diverse ancestries are limited, which hinders the practical ...
B. Truong, Leland E. Hull, Y. Ruan, Q. Huang, W. Hornsby, H. Martin, D. V. van Heel, Ying Wang, Alicia R. Martin, S. H. Lee, P. Natarajan   +10 more
semanticscholar   +1 more source