Results 171 to 180 of about 16,136 (210)

CRISPR-Cas9: bridging the gap between aging mechanisms and therapeutic advances in neurodegenerative disorders. [PDF]

Front Cell Neurosci
Shamsi A, Alrouji M, AlOmeir O, Tasqeruddin S, Dinislam K, Zuberi A.   +5 more
europepmc   +1 more source

Mechanism of Fast Axonal Transport Inhibition by Polyglutamine Expanded Huntingtin.

Sarah L. Pollema
openalex   +1 more source

L-arginine in patients with spinocerebellar ataxia type 6: a multicentre, randomised, double-blind, placebo-controlled, phase 2 trial. [PDF]

EClinicalMedicine
Ishihara T, Tada M, Kanemitsu Y, Takahashi Y, Ishikawa K, Ikenaka K, Hirano M, Yokota T, Minakawa EN, Saito K, Nagai Y, Onodera O.   +11 more
europepmc   +1 more source

Dendrite injury triggers neuroprotection in Drosophila models of neurodegenerative disease. [PDF]

Sci Rep
Prange SE, Bhakta IN, Sysoeva D, Jean GE, Madisetti A, Le HHN, Duong LU, Hwu PT, Melton JG, Thompson-Peer KL.   +9 more
europepmc   +1 more source

Disruption of the nascent polypeptide-associated complex leads to reduced polyglutamine aggregation and toxicity. [PDF]

PLoS One
Dublin-Ryan LB, Bhadra AK, True HL.
europepmc   +1 more source

Ataxin-3 Overexpression via Adeno-associated Viral Vector Injection in the Primate Cerebellum: A Novel Model of Spinocerebellar Ataxia Type 3. [PDF]

Exp Neurobiol
Kim K, Kim A, Won J, Park J, Lim KS, Jeon CY, Min J, Cho JH, Song Y, Koo BS, Bae GS, Jeon E, Jeong KJ, Park SH, Lee HY, Choi WS, Lee DS, Lee Y.   +17 more
europepmc   +1 more source

Loss of FIC-1-mediated AMPylation activates the UPRER and upregulates cytosolic HSP70 chaperones to suppress polyglutamine toxicity. [PDF]

PLoS Genet
Van Pelt KM, Truttmann MC.
europepmc   +1 more source

Oral KDS2010, a Monoamine Oxidase-B (MAO-B) Inhibitor, Slows the Deterioration of Motor Coordination in Genetic SCA1 Models by Inhibiting Astrocytic MAO-B-Mediated Inflammation. [PDF]

J Neurochem
Woo DH, Jeon JH, Ryu HJ, Lee GM, Lim HW, Park KD, Hoe KL, Rhee SD.   +7 more
europepmc   +1 more source

Targeting the mutant androgen receptor with PROTACs in spinal and bulbar muscular atrophy. [PDF]

Neurotherapeutics
Lee C, Lim J.
europepmc   +1 more source