Results 41 to 50 of about 21,037 (206)
The Emerging Role of microRNAs in Polyglutamine Diseases
Frontiers in Molecular Neuroscience, 2019 MicroRNAs (miRNAs) are small non-coding molecules that regulate a large amount of post-transcriptional repressor genes by recognizing semi-complementary target sequences that are normally located in the 3′ UTR of the mRNA. Altered expression of miRNA has
Xiaoyu Dong, Shuyan Cong
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Prion-Like Characteristics of Polyglutamine-Containing Proteins.
Cold Spring Harbor Perspectives in Medicine, 2018 Transmissible spongiform encephalopathies are infectious neurodegenerative diseases caused by the conversion of prion protein (PrP) into a self-replicating conformation that spreads via templated conversion of natively folded PrP molecules within or ...
Margaret M P Pearce, R. Kopito
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ACS Applied Materials and Interfaces, 2017 Prevention and therapeutic strategies for various neurodegenerative diseases focus on inhibiting protein fibrillation, clearing aggregated protein plaques from the brain, and lowering protein-aggregate-induced toxicity.
Koushik Debnath +4 more
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Polyglutamine repeats or cancer? [PDF]
Nature Reviews Clinical Oncology, 2012 It has previously been shown that patients with schizophrenia have a reduced risk of cancer than other individuals. This observation has been connected to the fact that tumour-suppressor genes, such as TP53 and APC, are upregulated. A team in Sweden, led by Jianguang Ji, have now asked if patients with Huntington's disease might also have protection ...
openaire +3 more sources
Nature Communications, 2017 Polyglutamine expansion in the huntingtin protein is the primary genetic cause of Huntington’s disease (HD). Fragments coinciding with mutant huntingtin exon1 aggregate in vivo and induce HD-like pathology in mouse models.
Hsiang-Kai Lin +8 more
semanticscholar +1 more source
eNeuro, 2017 Age-associated neurodegenerative diseases, such as Alzheimer’s disease, Parkinson’s disease, and the polyglutamine (polyQ) diseases, are becoming prevalent as a consequence of elongation of the human lifespan.
I. Tomioka +26 more
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Phase Separation Regulates Metabolism, Mitochondria, and Diseases
MedComm, Volume 6, Issue 7, July 2025.Mitochondrion‐related liquid–liquid phase separation. (1) Phase separation mediates the self‐assembly of mitochondrial nucleoids (mt‐nucleoids). (2) Phase segregation mediates the formation of mitochondrial RNA granules (MRGs). (3) Phase separation mediates the formation of mitochondrial degradosomes.
Chuan Gao +3 more
wiley +1 more source
Nanoscale studies link amyloid maturity with polyglutamine diseases onset
Scientific Reports, 2016 The presence of expanded poly-glutamine (polyQ) repeats in proteins is directly linked to the pathogenesis of several neurodegenerative diseases, including Huntington’s disease.
F. Ruggeri +8 more
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New Phytologist, Volume 247, Issue 2, Page 504-517, July 2025.Summary Repetitive DNA is a feature of all organisms, ranging from archaea and plants to humans. DNA repeats can be seen both in coding and in noncoding regions of the genome. Due to the recurring nature of the sequences, simple DNA repeats tend to be more prone to errors during replication and repair, resulting in variability in their unit length ...
Sridevi Sureshkumar +3 more
wiley +1 more source
Chaperones in Polyglutamine Aggregation: Beyond the Q-Stretch
Frontiers in Neuroscience, 2017 Expanded polyglutamine (polyQ) stretches in at least nine unrelated proteins lead to inherited neuronal dysfunction and degeneration. The expansion size in all diseases correlates with age at onset (AO) of disease and with polyQ protein aggregation ...
T. Outeiro +8 more
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