Results 11 to 20 of about 2,129,859 (190)
Autophagy and polyglutamine diseases. [PDF]
Prog Neurobiol, 2012 In polyglutamine diseases, an abnormally elongated polyglutamine tract results in protein misfolding and accumulation of intracellular aggregates. The length of the polyglutamine expansion correlates with the tendency of the mutant protein to aggregate ...
Jimenez-Sanchez M +3 more
europepmc +7 more sources
Are Polyglutamine Diseases Expanding? [PDF]
Neuron, 2011 It remains a matter of speculation as to whether the sense CUG-containing RNA and/or the antisense CAG-encoding polyglutamine peptide serves as the pathogenic moiety in Huntington's disease like-2 (HDL2). In this issue of Neuron, Wilburn et al. show that
Orr, Harry T., Harry T. Orr
core +4 more sources
Brain Sciences, 2014 Huntington disease and other diseases of polyglutamine expansion are each caused by a different protein bearing an excessively long polyglutamine sequence and are associated with neuronal death.
Guylaine Hoffner, Philippe Djian
doaj +2 more sources
Hosting Neurotoxicity in Polyglutamine Disease [PDF]
Cell, 2006 Polyglutamine diseases are caused by an expanded glutamine domain thought to confer a toxic activity onto the respective disease proteins. In this issue, Lam et al.
Liu, Nan, Bonini, Nancy M.
core +4 more sources
Polyglutamine Disease: Acetyltransferases Awry [PDF]
Current Biology, 2002 Recent evidence indicates that inhibition of histone acetyltransferases may be a primary cause of cellular pathogenesis in polyglutamine diseases such as Huntington disease; the results raise the possibility that pharmacologic manipulation of protein ...
Hughes, Robert E., Robert E. Hughes
core +4 more sources
Molecular origin of polyglutamine aggregation in neurodegenerative diseases. [PDF]
PLoS Computational Biology, 2005 Expansion of polyglutamine (polyQ) tracts in proteins results in protein aggregation and is associated with cell death in at least nine neurodegenerative diseases.
Sagar D Khare +3 more
doaj +5 more sources
Polyglutamine (PolyQ) Diseases: Genetics to Treatments [PDF]
Cell Transplantation, 2014 The polyglutamine (polyQ) diseases are a group of neurodegenerative disorders caused by expanded cytosine– adenine–guanine (CAG) repeats encoding a long polyQ tract in the respective proteins. To date, a total of nine polyQ disorders have been described:
Hueng-Chuen Fan +7 more
doaj +3 more sources
Polyglutamine disease: from pathogenesis to therapy. [PDF]
South African Medical Journal, 2012 Polyglutamine diseases are inherited neurodegenerative conditions arising from expanded trinucleotide CAG repeats in the disease-causing gene, which are translated into polyglutamine tracts in the resultant protein. Although these diseases share a common
Greenberg, LJ +3 more
core +6 more sources
Polyglutamine aggregation in huntington and related diseases [PDF]
, 2012 Polyglutamine (polyQ)-expansions in different proteins cause nine neurodegenerative diseases. While polyQ aggregation is a key pathological hallmark of these diseases, how aggregation relates to pathogenesis remains contentious.
Polling, S, Hatters, DM, Hill, AF
core +5 more sources
Editorial: The role of posttranslational modifications in polyglutamine diseases [PDF]
Frontiers in Molecular Neuroscience, 2023 Jonasz Jeremiasz Weber +5 more
doaj +2 more sources