Molecular origin of polyglutamine aggregation in neurodegenerative diseases. [PDF]
PLoS Computational Biology, 2005 Expansion of polyglutamine (polyQ) tracts in proteins results in protein aggregation and is associated with cell death in at least nine neurodegenerative diseases.
Sagar D Khare +3 more
doaj +5 more sources
Polyglutamine (PolyQ) Diseases: Genetics to Treatments [PDF]
Cell Transplantation, 2014 The polyglutamine (polyQ) diseases are a group of neurodegenerative disorders caused by expanded cytosine– adenine–guanine (CAG) repeats encoding a long polyQ tract in the respective proteins. To date, a total of nine polyQ disorders have been described:
Hueng-Chuen Fan +7 more
doaj +3 more sources
Editorial: The role of posttranslational modifications in polyglutamine diseases [PDF]
Frontiers in Molecular Neuroscience, 2023 Jonasz Jeremiasz Weber +5 more
doaj +2 more sources
Identification of Novel Therapeutic Targets for Polyglutamine Diseases That Target Mitochondrial Fragmentation [PDF]
International Journal of Molecular Sciences, 2021 Jeremy Van Raamsdonk +2 more
exaly +2 more sources
Extracellular Vesicles Physiological Role and the Particular Case of Disease-Spreading Mechanisms in Polyglutamine Diseases [PDF]
International Journal of Molecular Sciences, 2021 Pereira De Almeida L +2 more
exaly +2 more sources
The Missing Link in Polyglutamine Diseases. [PDF]
Mov Disord Clin Pract, 2018 Polyglutamine diseases are a group of nine hereditary neurodegenerative disorders and include Huntington disease (HD), the most prevalent spinocerebellar ataxias (SCAs type 1, 2, 3, 6, 7 and 17), dentatorubral-pallidoluysian atrophy and spinal and bulbar muscular atrophy (also known as Kennedy disease).
Aziz NA, Balint B.
europepmc +4 more sources
Studying polyglutamine diseases in Drosophila. [PDF]
Exp Neurol, 2015 Polyglutamine (polyQ) diseases are a family of dominantly transmitted neurodegenerative disorders caused by an abnormal expansion of CAG trinucleotide repeats in the protein-coding regions of the respective disease-causing genes. Despite their simple genetic basis, the etiology of these diseases is far from clear.
Xu Z, Tito AJ, Rui YN, Zhang S.
europepmc +4 more sources
Biomolecules, 2022 Nine heritable diseases are known that are caused by unphysiologically elongated polyglutamine tracts in human proteins leading to misfolding, aggregation and neurodegeneration.
Pauline Elisabeth Kolkwitz +2 more
doaj +1 more source
Autophagy and polyglutamine diseases.
Prog Neurobiol, 2012 In polyglutamine diseases, an abnormally elongated polyglutamine tract results in protein misfolding and accumulation of intracellular aggregates. The length of the polyglutamine expansion correlates with the tendency of the mutant protein to aggregate, as well as with neuronal toxicity and earlier disease onset.
Jimenez-Sanchez M +3 more
europepmc +6 more sources
Transcriptional Dysregulation and Post-translational Modifications in Polyglutamine Diseases: From Pathogenesis to Potential Therapeutic Strategies [PDF]
Frontiers in Molecular Neuroscience, 2018 Shuyan Cong, Ma Shuang, Cong Shuyan
exaly +2 more sources