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Polyhexamethylene biguanide and chloroquine induce programmed cell death in Acanthamoeba castellanii
Experimental Parasitology, 2018Several chemotherapeutic drugs have been described as amoebicidal agents acting against Acanthamoeba trophozoites and cysts. However, the underlying mechanism of action is poorly characterized. Here, we describe programmed cell death (PCD) in A. castellanii induced by polyhexamethylene biguanide (PHMB) and chloroquine. We used four types of amoebicidal
Eun-Kyung, Moon +3 more
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American Journal of Ophthalmology, 1993
We developed an intensive treatment regimen of topical neomycin, propamidine, and polyhexamethylene biguanide that was tapered to a maintenance level over a 14- to 28-day period as toxicity developed. Since July 1991, we used this treatment on six eyes of five patients in whom Acanthamoeba keratitis was diagnosed clinically.
J H, Varga +4 more
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We developed an intensive treatment regimen of topical neomycin, propamidine, and polyhexamethylene biguanide that was tapered to a maintenance level over a 14- to 28-day period as toxicity developed. Since July 1991, we used this treatment on six eyes of five patients in whom Acanthamoeba keratitis was diagnosed clinically.
J H, Varga +4 more
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[POLYHEXAMETHYLENE BIGUANID HYDROCHLORIDE (BIGUANELLE) THERAPY OF BACTERIAL VAGINOSIS].
Akusherstvo i ginekologiia, 2016The aim of our study was to determine the efficacy and tolerability of local therapy with polyhexamethylene biguanid hydrochloride (BIGUANELLE) in women with anaerobic vaginal infection.We include in our study 23 women (18-50) with established by AMSEL criteria bacterial vaginosis.
S, Kovachev +6 more
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Chlorhexidine or polyhexamethylene biguanide for acanthamoeba keratitis
The Lancet, 1995D V, Seal, J, Hay, C M, Kirkness
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[Preventing nosocomial infections. Dressings soaked in polyhexamethylene biguanide (PHMB)].
Revista de enfermeria (Barcelona, Spain), 2006Polyhexamethlene biguanide (PHMB) is an antibacterial agent included in the chlorhexidine group which is active against a wide number of microorganisms including Staphylococcus Aureus Methycilin Resistant (MRSA), Vancomycin Resistant Enterococcus Faecalis (VRE) and Acinetobacter baumannii which all cause antibiotic-resistant infections.
Luis, Salas Campos +3 more
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Polyhexamethylene Biguanide (PHMB): An Addendum to Current Topical Antimicrobials.
Wounds : a compendium of clinical research and practice, 2015Antimicrobials are routinely used in the treatment of chronic and problematic wounds. Despite the on-going increase in numbers and types of products, well-designed clinical trials that support their efficacy are limited. Antimicrobial products are applied with understanding of their mechanisms of action and role in wound repair. This manuscript reviews
Gerit D, Mulder +2 more
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EFFECTIVENESS OF POLYHEXAMETHYLENE BIGUANIDE AMONG PATIENT WITH DIABETIC WOUND
Abstract Diabetic wounds are injuries that occur in patients with diabetes that involve disturbances in the peripheral and autonomic nerves. Diabetic wounds are a major complication of diabetes and a global public health problem. There is no wound-cleansing intervention using Polyhexamethylene Biguanide as a wound-cleansing fluid against diabetic ...Naziyah +3 more
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The biocide polyhexamethylene biguanide remains an uncommon contact allergen.
Contact dermatitis, 2007Polyhexamethylene biguanide (PHMB) is used as a preservative in cosmetics and personal care products. Previous studies had shown a frequency of sensitization to PHMB of 0.5% and 0.4% in unselected dermatitis patients. The objective of this study was to determine the current frequency of sensitization to PHMB. From July 2005 until December 2005, a total
Axel, Schnuch +4 more
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