Results 1 to 10 of about 24,230,330 (112)

A Phenotypic and Genotypic Evaluation of Developmental Toxicity of Polyhexamethylene Guanidine Phosphate Using Zebrafish Embryo/Larvae

Toxics, 2020
Polyhexamethylene guanidine-phosphate (PHMG-P), a guanidine-based cationic antimicrobial polymer, is an effective antimicrobial biocide, potent even at low concentrations.
Jeongah Song, Kojo Eghan, Sangwoo Lee, Jong-Su Park, Seokjoo Yoon, Wittaya Pimtong, Woo-Keun Kim   +6 more
doaj   +2 more sources

Integrated evidence supports a causal association between PHMG-P exposure and pneumonitis [PDF]

Epidemiology and Health
Polyhexamethylene guanidine phosphate (PHMG-P) is a guanidine-based disinfectant previously used in household humidifiers in Korea. This study evaluated whether PHMG-P exposure is causally linked to pneumonitis by integrating epidemiological ...
Yong Joo Park, Hye-Jin Kim, Youngmee Lee, Haewon Kim, Ha Ryong Kim, Jaiyong Kim, Hae-Kwan Cheong, Mina Ha, Kyu Hyuck Chung   +8 more
doaj   +2 more sources

Polyhexamethylene Guanidine Phosphate Damages Tight Junctions and the F-Actin Architecture by Activating Calpain-1 via the P2RX7/Ca²⁺ Signaling Pathway

Cells, 2019
Polyhexamethylene guanidine phosphate (PHMG-p), a member of the polymeric guanidine family, has strong antimicrobial activity and may increase the risk of inflammation-associated pulmonary fibrosis.
Sun Woo Jin, Gi Ho Lee, Hoa Thi Pham, Jae Ho Choi, Hye Gwang Jeong   +4 more
doaj   +2 more sources

Non-Destructive Monitoring via Electrochemical NADH Detection in Murine Cells [PDF]

Biosensors, 2022
Nicotinamide adenine dinucleotide (NADH) is an important cofactor involved in metabolic redox reactions in living cells. The detection of NADH in living animal cells is a challenge.
Ju Kyung Lee, Han Na Suh, Sung Hoon Yoon, Kyu Hong Lee, Sae Young Ahn, Hyung Jin Kim, Sang Hee Kim   +6 more
doaj   +2 more sources

Evaluation of the long-term effect of polyhexamethylene guanidine phosphate in a rat lung model using conventional chest computed tomography with histopathologic analysis.

PLoS ONE, 2021
There have been no studies on the effects of polyhexamethylene guanidine phosphate (PHMG) after a long period of exposure in the rodent model. We aimed to evaluate long-term lung damage after PHMG exposure using conventional chest computed tomography (CT)
Cherry Kim, Sang Hoon Jeong, Jaeyoung Kim, Ja Young Kang, Yoon Jeong Nam, Ariunaa Togloom, Jaehyung Cha, Ki Yeol Lee, Chang Hyun Lee, Eun-Kee Park, Ju-Han Lee   +10 more
doaj   +1 more source

Fibrinogen on extracellular vesicles derived from polyhexamethylene guanidine phosphate-exposed mice induces inflammatory effects via integrin β

Ecotoxicology and Environmental Safety, 2023
Polyhexamethylene guanidine phosphate (PHMG-p), used as a humidifier disinfectant, causes interstitial lung disease, obliterative bronchiolitis, and lung fibrosis; however, little is known about its effect on intercellular interactions.
Jun Woo Kim, Mi Ho Jeong, Hyeong Tae Yu, Yong Joo Park, Hyung Sik Kim, Kyu Hyuck Chung   +5 more
doaj   +1 more source

Additional file 1 of Analysis of lung cancer-related genetic changes in long-term and low-dose polyhexamethylene guanidine phosphate (PHMG-p) treated human pulmonary alveolar epithelial cells

, 2022
Additional file 1. Supplementary Figure 1. Clinical significance of selected genes in patient with lung adenocarcinoma.
Lee, Hong, Jeong, Sang Hoon, Lee, Hyejin, Kim, Cherry, Nam, Yoon Jeong, Kang, Ja Young, Song, Myeong Ok, Choi, Jin Young, Kim, Jaeyoung, Park, Eun-Kee, Baek, Yong-Wook, Lee, Ju-Han   +11 more
openaire   +1 more source

Additional file 2 of Analysis of lung cancer-related genetic changes in long-term and low-dose polyhexamethylene guanidine phosphate (PHMG-p) treated human pulmonary alveolar epithelial cells

, 2022
Additional file 2. Supplementary Table 1.
Lee, Hong, Jeong, Sang Hoon, Lee, Hyejin, Kim, Cherry, Nam, Yoon Jeong, Kang, Ja Young, Song, Myeong Ok, Choi, Jin Young, Kim, Jaeyoung, Park, Eun-Kee, Baek, Yong-Wook, Lee, Ju-Han   +11 more
openaire   +1 more source

Additional file 3 of Analysis of lung cancer-related genetic changes in long-term and low-dose polyhexamethylene guanidine phosphate (PHMG-p) treated human pulmonary alveolar epithelial cells

, 2022
Additional file 3. Supplementary table 2.
Lee, Hong, Jeong, Sang Hoon, Lee, Hyejin, Kim, Cherry, Nam, Yoon Jeong, Kang, Ja Young, Song, Myeong Ok, Choi, Jin Young, Kim, Jaeyoung, Park, Eun-Kee, Baek, Yong-Wook, Lee, Ju-Han   +11 more
openaire   +1 more source

p53: A Key Protein That Regulates Pulmonary Fibrosis

Oxidative Medicine and Cellular Longevity, Volume 2020, Issue 1, 2020., 2020
Pulmonary fibrosis is a progressively aggravating lethal disease that is a serious public health concern. Although the incidence of this disease is increasing, there is a lack of effective therapies. In recent years, the pathogenesis of pulmonary fibrosis has become a research hotspot.
Qi Wu, Ke-jia Zhang, Shi-min Jiang, Lu Fu, Yue Shi, Ru-bin Tan, Jie Cui, Yao Zhou, Emiliano Barreto   +8 more
wiley   +1 more source