Results 21 to 30 of about 24,230,330 (112)

Polyhexamethylene guanidine phosphate exposure induces abnormal behaviors by disrupting synaptic formation and activity in the cerebral cortex [PDF]

Journal of Neuroinflammation
Background Polyhexamethylene guanidine phosphate (PHMG-p), a commonly utilized ingredient in humidifier disinfectants, has emerged as a primary factor contributing to pulmonary damage, asthmatic conditions, and prenatal complications in South Korea ...
Moon Yi Ko, Jiwon Choi, Euijun Min, Minjeong Kim, Mi-Kyung Song, Dong Im Kim, Jiyoung Park, Heejin Park, Byoung-Seok Lee, Kyuhong Lee, Sung-Ae Hyun, Minhan Ka   +11 more
doaj   +2 more sources

Assessment of the Diagnostic Value of [⁶⁸Ga]Ga-FAPI-04 and [¹⁸F]FDG PET in a PHMG-p-Induced Pulmonary Fibrosis Murine Model [PDF]

Diagnostics
Background/Objectives: Pulmonary fibrosis is a progressive and fatal lung disease with limited diagnostic and therapeutic options. Fibroblast activation protein (FAP) has emerged as a promising molecular imaging target for the non-invasive assessment of ...
So Young Kim, Jun Young Park, Ye Lim Cho, Won Jun Kang   +3 more
doaj   +2 more sources

Enhancing Lesion Detection in Rat CT Images: A Deep Learning-Based Super-Resolution Study [PDF]

Biomedicines
Background/Objectives: Preclinical chest computed tomography (CT) imaging in small animals is often limited by low resolution due to scan time and dose constraints, which hinders accurate detection of subtle lesions.
Sungwon Ham, Sang Hoon Jeong, Hong Lee, Yoon Jeong Nam, Hyejin Lee, Jin Young Choi, Yu-Seon Lee, Yoon Hee Park, Su A Park, Wooil Kim, Hangseok Choi, Haewon Kim, Ju-Han Lee, Cherry Kim   +13 more
doaj   +2 more sources

Nicotinamide adenine dinucleotide phosphate oxidase 2 deletion attenuates polyhexamethylene guanidine-induced lung injury in mice. [PDF]

Heliyon
Inhalation of polyhexamethylene guanidine phosphate (PHMG) can cause pulmonary fibrosis. Nicotinamide adenine dinucleotide phosphate (NADPH) oxidases (Nox) are enzymes that produce reactive oxygen species, which may be involved in tissue damage in ...
Cho Y, Jeon S, Kim SH, Kim HY, Kim B, Yang MJ, Rho J, Lee MY, Lee K, Kim MS.   +9 more
europepmc   +2 more sources

Organic Polyurethane Surface Structures to Manufacture Noneluting Antimicrobial Polyurethanes: A Systematic Review of Literature [PDF]

BioMed Research International, Volume 2026, Issue 1, 2026.
The dramatic increase in hospital‐acquired infections and healthcare costs associated with infection treatment and antimicrobial resistance in implant infections necessitates further research and development of antimicrobial implant material properties. Polyurethanes are key biomaterials used in medical implants and devices.
Bianca J. Hurck, Marian G. Vargas Guerrero, Candice de Boer, Aylvin A. Dias, Jacobus J. C. Arts, Seyed Shahmy   +5 more
wiley   +2 more sources

Longitudinal long term follow up investigation on the carcinogenic impact of polyhexamethylene guanidine phosphate in rat models [PDF]

Scientific Reports
Polyhexamethylene guanidine phosphate (PHMG-p) is a major component in humidifier disinfectants, which cause life-threatening lung injuries. However, to our knowledge, no published studies have investigated associations between PHMG-p dose and lung ...
Sang Hoon Jeong, Hong Lee, Yoon Jeong Nam, Ja Young Kang, Hyejin Lee, Jin Young Choi, Yu-Seon Lee, Jaeyoung Kim, Yoon Hee Park, Su A. Park, Hangseok Choi, Eun-Kee Park, Yong-Wook Baek, Jungyun Lim, Suejin Kim, Cherry Kim, Ju-Han Lee   +16 more
doaj   +2 more sources

Polyhexamethylene guanidine phosphate induces epithelial-to-mesenchymal transition and cancer stem cell-like properties via Wnt/β-catenin signaling in human bronchial epithelial cells

Ecotoxicology and Environmental Safety
Inhalation exposure to polyhexamethylene guanidine phosphate (PHMG-p), a primary component of humidifier disinfectants, has been linked to interstitial lung disease and potential carcinogenic effects.
Gi Ho Lee, Seung Yeon Lee, Yong-Wook Baek, Jungyun Lim, Kyu Hyuck Chung, Hye Gwang Jeong   +5 more
doaj   +2 more sources

Effects of Exposure of PHMG-p, a Humidifier Disinfectant Component, on Eye Dryness: A Study on a Rat Model Based on ¹H-NMR Metabolomics. [PDF]

Int J Mol Sci
Polyhexamethylene guanidine phosphate (PHMG-p), a widely used disinfectant component in household humidifiers, has been implicated in various health issues, including pulmonary toxicity. Many people use humidifiers to improve dry eye disease (DED).
Lee JD, Kim HY, Oh SB, Goo H, Cho KJ, Hwang GW, Kim S, Kim KB.   +7 more
europepmc   +2 more sources

A review of current studies on cellular and molecular mechanisms underlying pulmonary fibrosis induced by chemicals [PDF]

Environmental Health and Toxicology, 2018
Several studies showed that the inflammatory and fibrotic responses induced by polyhexamethylene guanidine phosphate (PHMG-p) were similar to those observed for idiopathic pulmonary fibrosis in South Korea in 2011.
Ha Ryong Kim, Da Young Shin, Kyu Hyuck Chung   +2 more
doaj   +1 more source

Occupational interstitial lung diseases

Journal of Internal Medicine, Volume 294, Issue 6, Page 798-815, December 2023., 2023
Abstract Millions of workers are exposed to substances known to cause occupational interstitial lung diseases (ILDs), particularly in developing countries. However, the burden of the disease is likely to be underestimated due to under‐recognition, under‐reporting or both.
Paolo Spagnolo, Christopher J. Ryerson, Sabina Guler, Johanna Feary, Andrew Churg, Andrew P. Fontenot, Sara Piciucchi, Zarir Udwadia, Tamera J. Corte, Wim A. Wuyts, Kerri A. Johannson, Vincent Cottin   +11 more
wiley   +1 more source