Investigation of asparagine-linked glycosylation in archaeal and bacterial systems [PDF]
, 2011 Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Chemistry, February 2011.Vita. Cataloged from PDF version of thesis.Includes bibliographical references.Asparagine-linked protein glycosylation entails the stepwise assembly of an ...
Larkin, Angelyn (Angelyn Kathryne)
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Structural and Biochemical Characterization of ArnC and ArnD: Key Enzymes in Lipid a Modification With Ara-4N and Polymyxin Resistance [PDF]
, 2023 Antibiotic resistance is an increasing global concern threatening our ability to fight bacterial infections. A key part of the innate immune response is Cationic Antimicrobial Peptides (CAMPs) that constitute an effective defense barrier against ...
Munoz-Escudero, Daniel
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Investigating asparagine-linked protein glycosylation in eukaryotic and prokaryotic systems [PDF]
, 2006 Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Chemistry, 2006.Vita.Includes bibliographical references.N-linked protein glycosylation is characterized by the formation of a -glycosylamine linkage to an asparagine residue within the Asn-
Weerapana, Eranthie
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Quantification of dolichol in the human lens with different types of cataracts. [PDF]
, 2009 PURPOSE: To quantify and characterize dolichol species in cataractous and clear human lenses. METHODS: Whole lenses were collected from cadaver eyeballs from the C.H. Nagri Eye Bank and Red Cross Society Eye Bank (Ahmedabad, India). Cataractous nuclei
Gajjar, Devarshi +6 more
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Lipid-Modulated, Graduated Inhibition of N‑Glycosylation Pathway Priming Suggests Wide Tolerance of ER Proteostasis to Stress [PDF]
Protein N-glycosylation is a cotranslational modification that takes place in the endoplasmic reticulum (ER). Disruption of this process can result in accumulation of misfolded proteins, known as ER stress. In response, the unfolded protein response (UPR)
Carpenter, EP +13 more
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Structure-Function Analysis of UDP-Sugar: Polyisoprenyl Phosphate Sugar-1-Phosphate Transferases [PDF]
, 2013 The synthesis of lipid-linked glycans is a conserved process in eukaryotes and prokaryotes that is initiated by two major enzyme families: the polyisoprenyl-phosphate hexose-1-phosphate transferases (PHPTs) and the polyisoprenyl-phosphate N-acetylaminosugar-1-phosphate transferases (PNPTs). These enzymes contain multiple membrane domains and transfer a
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The Journal of biological chemistry, 1998 Microsomal fractions from pig and calf brain catalyze the enzymatic dephosphorylation of endogenous and exogenous dolichyl monophosphate (Dol-P) (Sumbilla, C. A., and Waechter, C. J. (1985) Methods Enzymol. 111, 471-482). The Dol-P phosphatase (EC 3.1.3.51) has been solubilized by extracting pig brain microsomes with the nonionic detergent Nonidet P-40
D W, Frank, C J, Waechter
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Structure-Function Analysis of Enzymes of the Polyisoprenyl-Phosphate Hexose-1-Phosphate Transferase family [PDF]
, 2011 Enzymes of the polyisoprenyl-phosphate hexose-1-phosphate transferase (PHPT) family are integral membrane proteins that initiate the synthesis of glycans by catalyzing the transfer of a hexose-1-phosphate sugar from UDP-hexose to the lipid carrier undecaprenyl phosphate (Und-P).
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Endogenous Receptor Agonists: Resolving Inflammation [PDF]
, 2007 Controlled resolution or the physiologic resolution of a well-orchestrated inflammatory response at the tissue level is essential to return to homeostasis. A comprehensive understanding of the cellular and molecular events that control the termination of
Charles N. Serhan +2 more
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Coordination of Primer Sugar Synthesis with O-antigen Initiation in Rhizobium Etli CE3 [PDF]
, 2014 All organisms synthesize amidosugars, such as N-acetylglucosamine (GlcNAc), and deoxysugars, such as fucose. They are found in important polysaccharides and glycoconjugates such as glycoproteins.
Li, Tiezheng
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