Results 121 to 130 of about 23,262 (184)

Molecular basis for depsipeptide HDAC inhibitor combinatorial biosynthesis

Nature Communications
Polyketides and nonribosomal peptides are important natural product classes with wide-ranging medical and agricultural applications. The analogous enzymatic logic employed by bacterial modular polyketide synthases (PKSs) and nonribosomal peptide ...
Munro Passmore, Xinyun Jian, Xinyi Zhao, Emmanuel L. C. de los Santos, Douglas M. Roberts, Józef R. Lewandowski, Matthew Jenner, Lona M. Alkhalaf, Gregory L. Challis   +8 more
doaj   +1 more source

Protocol for the purification, analysis, and handling of acyl carrier proteins from type I fatty acid and polyketide synthases

STAR Protocols
Summary: Acyl carrier proteins (ACPs) are key domains in fatty acid and polyketide synthases (PKSs), shuttling intermediates to catalytic partners. Here, we present a protocol for purifying and analyzing ACPs from fatty acid synthases (FASs) and PKSs ...
Christian Gusenda, Svenja Berlage, Ines Burkhart, Benjamin Chagot, Kira J. Weissman, Harald Schwalbe, Martin Grininger   +6 more
doaj   +1 more source

Groundnut Improvement for Aflatoxin Resistance: Progress and Opportunities

Food and Energy Security, Volume 15, Issue 5, September/October 2026.
ABSTRACT Groundnut, or peanut, is an industrial oilseed crop that serves the food and feed industries and provides income along the value chain. Pre‐ and post‐harvest aflatoxin contamination, caused by Aspergillus spp., hinders the food and feed value and market opportunities of groundnut products. Developing and deploying aflatoxin‐resistant varieties
Tullu Tadessa Asefa, Hussein Shimelis, Janila Pasupuleti, Seltene Abady Tesfamariam   +3 more
wiley   +1 more source

Rational Domain Swaps Decipher Programming in Fungal Highly Reducing Polyketide Synthases and Resurrect an Extinct Metabolite

, 2011
The mechanism of programming of iterative highly reducing polyketide synthases remains one of the key unsolved problems of secondary metabolism. We conducted rational domain swaps between the polyketide synthases encoding the biosynthesis of the closely ...
Wasil, Z, Simpson, T.J, Ahmed A. Yakasai, Yakasai, A, Colin M. Lazarus, Pedrick, J, Fisch, K.M, Bakeer, W.I.M, Cox, R.J, Lazarus, C.M, Bailey, A.M, Katja M. Fisch, Walid Bakeer, Zhongshu Song, Thomas J. Simpson, Jennifer Pedrick, Zahida Wasil, Andrew M. Bailey, Song, Z, Russell J. Cox   +19 more
core   +1 more source

Metabolic feature profiling and metabolic vulnerability in acute lymphoblastic leukemia

Interdisciplinary Medicine, Volume 4, Issue 5, September 2026.
For the first time, our study develops a novel metabolic classification and subtyping program, metabolic reprogramming‐based classifier for acute lymphoblastic leukemia, using internal PDT‐ALL‐2016 and external cohorts, which dissects metabolic profiling, clinical outcome, and therapeutic vulnerability for precision metabolic intervention in ALL ...
Xiaojie Liang, Zihong Cai, Bingqing Tang, Zicong Huang, Baiwei Luo, Bingyu Lin, Yunong Yang, Zhihao Jin, Xiaoqing Li, Xiuli Xu, Yeling Deng, Chaoran Lin, Liang Wang, Hongsheng Zhou   +13 more
wiley   +1 more source

The Structural Enzymology of Iterative Aromatic Polyketide Synthases: A Critical Comparison with Fatty Acid Synthases

, 2018
Polyketides are a large family of structurally complex natural products including compounds with important bioactivities. Polyketides are biosynthesized by polyketide synthases (PKSs), multienzyme complexes derived evolutionarily from fatty acid ...
Shiou-Chuan (Sheryl) Tsai
core   +1 more source

Microbiome‐mediated chemical communication in insects: Implications for pest management

Pest Management Science, Volume 82, Issue 9, Page 8132-8151, September 2026.
Microbiome–semiochemical interactions involve the following processes: direct microbial synthesis, host gene regulation, precursor biotransformation, microbiome modulation and indirect ecological signaling. Abstract Insects rely on semiochemicals to regulate aggregation, mating, foraging, and host selection. This review synthesizes evidence that insect‐
Ioannis Eleftherianos, Wei Zhang, Amr Mohamed, Rasha K. Al‐Akeel, Abeer M. Alkhaibari, Nemat Keyhani, Guy Smagghe   +6 more
wiley   +1 more source

Advances in large DNA fragment assembly for microbial cell factory engineering

Quantitative Biology, Volume 14, Issue 3, September 2026.
Abstract The efficient, rapid, and reliable assembly of DNA fragments is essential for advancing metabolic engineering and synthetic biology. With the rapid advancement of DNA synthesis and assembly technologies, the scale of DNA assembly has expanded from single genes to metabolic pathways and even genomes.
Yu Zhang, Wenqian Liu, Dongyuan Cheng, Jiazhang Lian, Xian Fu, Yue Shen   +5 more
wiley   +1 more source

Systematic prioritization of candidate genes in camptothecin biosynthesis using multi‐omics and deep learning

The Plant Genome, Volume 19, Issue 3, September 2026.
Abstract Camptothecin (CPT), a plant‐derived monoterpene indole alkaloid first identified in Camptotheca acuminata, is a drug precursor widely used for cancer chemotherapeutics. However, the full set of genes responsible for CPT biosynthesis remains unclear, hindering efforts to elucidate the complete pathway or establish biosynthetic production of CPT
Shenqi Wang, Xing Wu, Maria Moreno, Joonseok Oh, Stephen L. Dellaporta, Jason M. Crawford, Farren J. Isaacs   +6 more
wiley   +1 more source

Diversity and Distribution of Non-Reducing Polyketide Synthases (NR-PKSs) in Ascomycota (Fungi)

Journal of Fungi
(1) Background: This study highlights the diversity and distribution of non-reducing polyketide synthases (NR-PKSs) in Ascomycota and their role in producing bioactive aromatic polyketides.
Pritam Chattopadhyay, Goutam Banerjee
doaj   +1 more source