Presence of polyketide synthases and nonribosomal peptide synthetase in culturable bacteria associated with Aplysina fulva and Aplysina caissara (Porifera). [PDF]
Rojas LS +8 more
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Gatekeeping Activity of Collinear Ketosynthase Domains Limits Product Diversity for Engineered Type I Polyketide Synthases. [PDF]
Yi D, Wakeel MA, Agarwal V.
europepmc +1 more source
Characterisation of Modular Polyketide Synthases Designed to Make Pentaene Analogues of Amphotericin B. [PDF]
Song Y +4 more
europepmc +1 more source
Architecture of full-length type I modular polyketide synthases revealed by X-ray crystallography, cryo-electron microscopy, and AlphaFold2. [PDF]
Bagde SR, Kim CY.
europepmc +1 more source
Correction for Wang et al., Unraveling the iterative type I polyketide synthases hidden in Streptomyces. [PDF]
europepmc +1 more source
Cloning of three Alnus sieboldiana type III polyketide synthases and formation of polyketides in recombinant Escherichia coli using cinnamic acid analogs as substrates. [PDF]
Takemoto K +4 more
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Evolution and Diversity of Assembly-Line Polyketide Synthases. [PDF]
Nivina A, Yuet KP, Hsu J, Khosla C.
europepmc +1 more source
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Manipulation of Modular Polyketide Synthases
Chemical Reviews, 1997Leonard Katz
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Biosynthesis of polyketides by trans-AT polyketide synthases
Natural Product Reports, 2016This review discusses the biosynthesis of natural products that are generated bytrans-AT polyketide synthases, a family of catalytically versatile enzymes that represents one of the major group of proteins involved in the production of bioactive polyketides.
Helfrich Eric J N, Piel Jörn
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Tolerance and Specificity of Polyketide Synthases
Annual Review of Biochemistry, 1999▪ Abstract Polyketide synthases catalyze the assembly of complex natural products from simple precursors such as propionyl-CoA and methylmalonyl-CoA in a biosynthetic process that closely parallels fatty acid biosynthesis. Like fatty acids, polyketides are assembled by successive decarboxylative condensations of simple precursors.
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