Results 151 to 160 of about 27,763 (265)

A ‘Genome‐First’ Framework for Next‐Generation Bioinputs: From Functional Mining to Rational Synthetic Microbial Communities

Environmental Microbiology, Volume 28, Issue 5, May 2026.
I propose a ‘genome‐first’ framework to collapse the phenotypic bottleneck in bioinput discovery. By integrating multi‐layered genome mining and reverse ecology, this paradigm enables the rational design of stable synthetic microbial communities for a data‐driven and sustainable agricultural bioeconomy.
Osiel Silva Gonçalves
wiley   +1 more source

Multi‐Omic Assessment of Microbial Communities and Their Polyketide Biosynthetic Potential Across Abyssal Sediments

Environmental Microbiology, Volume 28, Issue 5, May 2026.
Abyssal sediments were assessed for taxonomic diversity and polyketide biosynthetic potential and compared to metagenomic and metabolomic assessments of the same sediments. Biodiversity differences were documented across biogeochemical regimes with the results providing baseline awareness of what might be lost should deep‐sea microbiomes be disrupted ...
Hans W. Singh, Johanna Gutleben, Alexander Bogdanov, Alexander B. Chase, Alyssa Demko, Sheila Podell, Brian Haley, Paul R. Jensen   +7 more
wiley   +1 more source

Characterization of the Orphan Cytochrome P450 CYP107J1 From Bacillus subtilis Through Peroxygenase Activity Engineering

Microbial Biotechnology, Volume 19, Issue 5, May 2026.
The orphan cytochrome P450 CYP107J1 with unknown redox partners was rationally modified into H2O2‐driven form. The QE (E251Q/T252E) mutant produced valuable chemicals by simply mixing the enzyme with substrate and H2O2. ABSTRACT Cytochrome P450 monooxygenases (P450s) not only play many physiological roles in oxidative metabolism but are also promising ...
Hideki Kato, Takafumi Hashimoto, Tuhin Das, Daniel Z. Doherty, Stephen G. Bell, Toshiki Furuya   +5 more
wiley   +1 more source

Draft genome of Neofabraea vagabunda, the agent of bull's eye rot

Annals of Applied Biology, Volume 188, Issue 3, Page 941-946, May 2026.
Circular representation of the 12 major scaffolds from the draft genome of Neofabraea vagabunda showing gene density, density of repeated regions, GC content, and functional features (secrete and membrane proteins, proteases, and CAZymes) distribution.
Saveria Mosca, Antonino Malacrinò, Nesma Zakaria Mohamed, Martina Lucci, Alessandra Di Francesco   +4 more
wiley   +1 more source

Targeted Discovery of β‑Branched Conjugated Polyketides from Bacteria Based on Genomic and Metabolomic Hallmarks. [PDF]

JACS Au
Cui J, Kang I, Lee H, Heo BE, Ye S, Lee J, Moon DH, Bae ES, Ock CW, Shin D, An JS, Kang HS, Lee SK, Oh KB, Cho I, Kim HY, Kim Y, Jang J, Cho JC, Oh DC.   +19 more
europepmc   +1 more source

Familial Adenomatous Polyposis—Risk of Cancer, Cancer Prevention, and Long‐Term Consequences: Learnings from Five Decades with the Danish Polyposis Register

APMIS, Volume 134, Issue 5, May 2026.
ABSTRACT Familial adenomatous polyposis (FAP) is a hereditary condition marked by the growth of hundreds to thousands of adenomatous polyps in the colon and rectum, significantly elevating the risk of colorectal cancer (CRC) if left untreated. Caused by pathogenic variants in the APC gene, FAP is typically identified in adolescence, often leading to ...
John Gásdal Karstensen
wiley   +1 more source

Untargeted Metabolomics for Profiling of Cascara, Senna, Rhubarb, and Frangula Metabolites. [PDF]

Metabolites
Nezi P, Prete AL, Costanti F, Cicaloni V, Cicogni M, Tinti L, Salvini L, Bianchini M.   +7 more
europepmc   +1 more source

Early‐Onset Digestive System Cancers: Risk Factors and Clinicopathological and Molecular Features Across Organ Sites

Cancer Science, Volume 117, Issue 5, Page 1223-1234, May 2026.
Shared risk factors, clinical features, and tumor characteristics across multiple early‐onset cancer types are shown in this Graphical Abstract. Integrative approaches combining molecular pathology, oncology, and population sciences offer opportunities to clarify underlying mechanisms and help us develop preventive strategies for early‐onset cancers ...
Nobuhiro Nakazawa, Satoko Ugai, Atsushi Kondo, Kosuke Matsuda, Shu Kato, Genki Usui, Shiori Tanaka, Hwa‐Young Lee, Xinyuan Zhang, Hideo Miyagawa, Mai Chan Lau, Hiroshi Saeki, Yukihide Kanemitsu, Andrew T. Chan, Shuji Ogino, Minkyo Song, Juha P. Väyrynen, Tomotaka Ugai   +17 more
wiley   +1 more source

NRPS and PKS pathways in actinomycetes: A review of biosynthetic diversity and bioactive potential. [PDF]

Curr Res Pharmacol Drug Discov
Chauhan A, Gurnani M, Arora J, Chauhan R, Ranjan A, Chandra Joshi N, Dufossé L, Jindal T.   +7 more
europepmc   +1 more source

Enzymatic synthesis of bioactive quinolones and (thio)coumarins by fungal type III polyketide synthases

The FEBS Journal, Volume 293, Issue 9, Page 2673-2691, May 2026.
Quinolones are valuable scaffolds for drug discovery but are rare in nature. Here, we show that two fungal enzymes, AthePKS and FerePKS, can generate 2‐quinolones and two additional heteroaromatic scaffolds. Using AthePKS, we designed an artificial enzymatic cascade towards an antimicrobial quinolone from a simple precursor and implemented it in E ...
Nika Sokolova, Angelina Osipyan, Lili Zhang, Matthew R. Groves, Sandy Schmidt, Kristina Haslinger   +5 more
wiley   +1 more source