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Engineering of modular polyketide synthases to produce novel polyketides
Current Opinion in Biotechnology, 1998Polyketides are important natural products produced by Actinomycetes and other organisms via the polymerization of coenzyme A-activated carboxylic acids. Modular polyketide synthases are large multifunctional enzymes that direct the biosynthetic process using a dedicated 'module' for each polymerization reaction, which specifies the unit to be ...
, Carreras, , Santi
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Biosynthesis of polyketides by trans-AT polyketide synthases in Burkholderiales
Critical Reviews in Microbiology, 2019Widely used as drugs and agrochemicals, polyketides are a family of bioactive natural products, with diverse structures and functions. Polyketides are produced by megaenzymes termed as polyketide synthases (PKSs). PKS biosynthetic pathways are divided into the cis-AT PKSs and trans-AT PKSs; a division based mainly on the absence of an acyltransferase ...
Hanna, Chen +10 more
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Towards engineered polyketides
Expert Opinion on Investigational Drugs, 1998Rapid advances have been made over the past 10 years in the identification of the biosynthetic machinery that carries out the biosynthesis of polyketide natural products. Many such compounds are used in various therapeutic areas, including antibacterials, anticancer, antifungals and cholesterol lowering.
J, Staunton, B, Wilkinson
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Cell-free synthesis of polyketides by recombinant erythromycin polyketide synthases
Nature, 1995Modular polyketide synthases (PKSs) are complex multi-enzyme proteins that catalyse the bacterial biosynthesis of many pharmaceutically useful polyketides. The PKSs are organized into a series of modules, each containing the active catalytic sites required for one step in the synthesis process.
R, Pieper, G, Luo, D E, Cane, C, Khosla
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1994
This chapter discusses the condensation of acetyl-SCoA with malonyl-SCoA units that gives rise to numerous aromatic compounds, many of which have meta-disposition of hydroxyl groups. It mentions products of the polyketide pathway and its typical examples, such as 6-methylsalicyclicacid, antifungal compound griseofulvin, mycotoxins patulin, and ...
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This chapter discusses the condensation of acetyl-SCoA with malonyl-SCoA units that gives rise to numerous aromatic compounds, many of which have meta-disposition of hydroxyl groups. It mentions products of the polyketide pathway and its typical examples, such as 6-methylsalicyclicacid, antifungal compound griseofulvin, mycotoxins patulin, and ...
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Production of a novel polyketide through the construction of a hybrid polyketide synthase
Gene, 1996The lactone rings of the polyketides platenolide and tylactone are synthesized by condensation of acetate-, proprionate-, and butyrate-derived precursors. A hybrid tylactone/platenolide synthase was constructed to determine if the choice of substrate is programmed by the polyketide synthase and to ascertain if a substrate different than that normally ...
S, Kuhstoss +4 more
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ChemInform Abstract: Biosynthesis of Polyketides by trans‐AT Polyketide Synthases
ChemInform, 2010AbstractReview: 436 refs.
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