Results 21 to 30 of about 1,639,414 (226)

Making tau amyloid models in vitro: a crucial and underestimated challenge

FEBS Letters, EarlyView.
This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley   +1 more source

Polymer Release out of a Spherical Vesicle through a Pore

, 1998
Translocation of a polymer out of curved surface or membrane is studied via mean first passage time approach. Membrane curvature gives rise to a constraint on polymer conformation, which effectively drives the polymer to the outside of membrane where the
B. Alberts, F. von Goeler, K. Schulten, Pyeong Jun Park, W. Sung, Wokyung Sung   +5 more
core   +1 more source

Phase diagram for a mixture of colloids and polymers with equal size [PDF]

, 2008
We present the phase diagram of a colloid-polymer mixture in which the radius a of the colloidal spheres is approximately the same as the radius R of a polymer coil (q=R/a1).
Tuinier, R., Smith, P.A., Poon, W.C.K., Egelhaaf, S.U., Aarts, D.G.A.L., Lekkerkerker, H.N.W., Fleer, G.J., Colloïden en grenslagen, Dep Scheikunde   +8 more
core   +2 more sources

The cytoskeletal control of B cell receptor and integrin signaling in normal B cells and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
In lymphoid organs, antigen recognition and B cell receptor signaling rely on integrins and the cytoskeleton. Integrins act as mechanoreceptors, couple B cell receptor activation to cytoskeletal remodeling, and support immune synapse formation as well as antigen extraction.
Abhishek Pethe, Tanja Nicole Hartmann
wiley   +1 more source

Autophagy in cancer and protein conformational disorders

FEBS Letters, EarlyView.
Autophagy plays a crucial role in numerous biological processes, including protein and organelle quality control, development, immunity, and metabolism. Hence, dysregulation or mutations in autophagy‐related genes have been implicated in a wide range of human diseases.
Sergio Attanasio
wiley   +1 more source

A stepwise emergence of evolution in the RNA world

FEBS Letters, EarlyView.
How did biological evolution emerge from chemical reactions? This perspective proposes a gradual scenario of self‐organization among RNA molecules, where catalytic feedback on random mixtures plays the central role. Short oligomers cross‐ligate, and self‐assembly enables heritable variations. An event of template‐externalization marks the transition to
Philippe Nghe
wiley   +1 more source

A flexible polymer chain in a critical solvent: Coil or globule?

, 2015
We study the behavior of a flexible polymer chain in the presence of a low-molecular weight solvent in the vicinity of a liquid-gas critical point within the framework of a self-consistent field theory.
Budkov, Yu. A., Georgi, N., Kiselev, M. G., Kolesnikov, A. L.   +3 more
core   +1 more source

Modeling the heat transfer by conduction of nanocellular polymers with bimodal cellular structures [PDF]

, 2019
Nanocellular polymers are a new generation of materials with the potential of being used as very efficient thermal insulators. It has been proved experimentally that these materials present the Knudsen effect, which strongly reduces the conductivity of ...
Bernardo García, Victoria, Martín de León, Judit, Pinto Sanz, Javier, Rodríguez Pérez, Miguel Ángel, Verdejo, Raquel   +4 more
core   +1 more source

Ignition mechanisms in polymers and polymer nanocomposites [PDF]

Polymers for Advanced Technologies, 2011
This paper addresses the behavior of thermoplastic polymers and polymer nanocomposites prior to ignition, under irradiation in a cone calorimeter. Insights into the physical evolution of material controlling ignition are obtained from the measurement of the condensed phase surface temperature and by the observation of specimen residues obtained from ...
FINA, ALBERTO, CAMINO, GIOVANNI
openaire   +6 more sources

Cellular liquid biopsy provides unique chances for disease monitoring, preclinical model generation and therapy adjustment in rare salivary gland cancer patients

Molecular Oncology, EarlyView.
We quantified and cultured circulating tumor cells (CTCs) of 62 patients with various cancer types and generated CTC‐derived tumoroid models from two salivary gland cancer patients. Cellular liquid biopsy‐derived information enabled molecular genetic assessment of systemic disease heterogeneity and functional testing for therapy selection in both ...
Nataša Stojanović Gužvić, Florian Lüke, Steffi Treitschke, Andrea Coluccio, Martin Hoffmann, Giancarlo Feliciello, Adithi Ravikumar Varadarajan, Xin Lu, Kathrin Weidele, Catherine Botteron, Silvia Materna–Reichelt, Felix Keil, Katja Evert, Florian Weber, Thomas Schamberger, Michael Althammer, Jirka Grosse, Dirk Hellwig, Christian Schulz, Stephan Seitz, Peter Ugocsai, Anke Schlenska‐Lange, Roman Mayr, Ulrich Kaiser, Wolfgang Dietmaier, Bernhard Polzer, Jens Warfsmann, Kamran Honarnejad, Tobias Pukrop, Daniel Heudobler, Christoph A. Klein, Christian Werno   +31 more
wiley   +1 more source