Results 41 to 50 of about 646,069 (216)
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Nanofiller Fibre-Reinforced Polymer Nanocomposites [PDF]
, 2008 In this work, the technology of nano and micro-scale particle reinforcement concerning various polymeric fibre-reinforced systems including polyamides (PA), polyesters, polyurethanes, polypropylenes and high performance/temperature engineering ...
Pielichowski, Krzysztof +2 more
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KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
Jetting behavior of polymer solutions in drop-on-demand inkjet printing
, 2012 The jetting of dilute polymer solutions in drop-on-demand printing is investigated. A quantitative model is presented which predicts three different regimes of behavior depending upon the jet Weissenberg number Wi and extensibility of the polymer ...
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Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Diffuse interface modelling of the rheology of immiscible polymer blends [PDF]
, 2002 The objective of this work is to predict macroscopic properties of polymer blends, such as the first normal stress difference based on the information obtained with simulations of morphology development on a microstructural level.
Keestra, BJ +8 more
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Solid-supported polymer bilayers as membrane mimics [PDF]
, 2010 Membranes are one of Nature’s most remarkable designs. Due to their importance in numerous cellular processes, they are prominent subjects of biochemical and biophysical fundamental research.
Belegrinou, Serena
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Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
POLYMER MODIFIED ASPHALT NANOCOMPOSITES
, 2011 Asphalt one of the versatile materials of antique, inspite of its compositional variations and complexities, widely employed in various applications like water proofing, paving etc. Due to the complex physical and chemical nature, Asphalt seldom performs
MARKANDAY SUBRAMANIAN, SURESHKUMAR
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