Results 41 to 50 of about 1,860,269 (264)

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Flexible polymer-induced condensation and bundle formation of DNA and F-actin filaments [PDF]

, 2001
A simple semi-empirical theory is developed for the ionic strength dependence of the flexible polymer-induced condensation of semiflexible polyelectrolytes such as DNA and F-actin filaments.
Vries, R., de
core  

Nanowires Properties and Applications: A Review Study

South African Journal of Chemical Engineering, 2023
One-dimensional nanostructures are generally cited as nanowires, nanofibers, nanotubes, and so on. The foremost prominent feature of these materials is their electrical conductivity, which, unlike classical physics, doesn't increase their resistance ...
Chou-Yi Hsu, Ahmed Mahdi Rheima, Zainab sabri Abbas, Muhammad Usman Faryad, Mustafa M. Kadhim, Usama S. Altimari, Ashour H. Dawood, Alaa dhari jawad al-bayati, Zainab Talib Abed, Rusul Saeed Radhi, Asala Salam Jaber, Safa K. Hachim, Farah K. Ali, Zaid H Mahmoud, Ghobad Behzadi pour, Ehsan Kianfar   +15 more
doaj   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Scattering studies from polymer blends. [PDF]

, 1979
Polymer Science and EngineeringDoctor of Philosophy (Ph.D.
Russell, Thomas P.
core   +1 more source

Segmented multiblock polyolefin compatibilizers from non-living metathesis chain-shuffling

Nature Communications
The mechanical properties of mixed plastics can be enhanced by block copolymer compatibilizer additives. Here we report a series of semi-crystalline/semi-crystalline linear multiblock copolymers of LLDPE and PP, the two most abundant plastics, from a non-
Abhishek Banerjee, Navin Kafle, Walter G. Romano, Harsh Pandya, Shin Horiuchi, Aarushi Srivastava, Fardin Khabaz, Mark D. Foster, Toshikazu Miyoshi, James M. Eagan   +9 more
doaj   +1 more source

Microplastic Pollution in Tropical River: Fourier Transform Infrared Spectroscopy-Based Characterization of Abundance and Polymer Composition in Water and Sediments from Filobobos River, Mexico

Hydrology
Veracruz is a megadiverse state facing great water resource management challenges. The contamination of water bodies with external materials of anthropogenic origin stands out, including those derived from plastic products, which are deemed ubiquitous ...
Gleybis Hernández-Morales, María Cristina López-Mendez, Alan Antonio Rico-Barragán, Jesús Pérez-Moreno, Carolina Peña-Montes, Luis Alberto Peralta-Pelaez, Humberto Raymundo González-Moreno   +6 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Multiscale Implications of Stress-Induced Ionic Polymer Transducer Sensing [PDF]

, 2013
Ionic Polymer Transducers (IPTs) can act as both actuators and sensors. As actuators, the energy density values are much better than PZT or PVDF materials.
Zangrilli, Ursula
core  

Polymeric and Crystalline Materials for Effective and Sustainable CO₂ Capture

AppliedChem
Carbon dioxide (CO2) is recognized as the primary cause of global warming due to its greenhouse potential. It plays a significant role in contributing to the emissions arising from a variety of anthropogenic activities, such as energy production ...
David Gendron, Maria Zakharova
doaj   +1 more source