Results 71 to 80 of about 4,899,356 (394)

The role of histone modifications in transcription regulation upon DNA damage

FEBS Letters, EarlyView.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source

Dynamic surface decoupling in a sheared polymer melt [PDF]

, 2005
We propose that several mechanisms contribute to friction in a polymer melt adsorbed at a structured surface. The first one is the well known disentanglement of bulk polymer chains from the surface layer.
Andrienko D., Cieplak M., Cottin-Bizonne C., D Andrienko, Grest G. S., K Kremer, Klein J., L. Delle Site, Leon S., Léger L., Persson B. N. J., X Zhou   +11 more
core   +2 more sources

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Localization and diffusion in polymer quantum field theory

, 2014
Polymer quantization is a non-standard approach to quantizing a classical system inspired by background independent approaches to quantum gravity such as loop quantum gravity.
Arzano, Michele, Letizia, Marco
core   +2 more sources

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Polymer/molecular semiconductor all-organic composites for high-temperature dielectric energy storage

Nature Communications, 2020
Dielectric polymers for electrostatic energy storage suffer from low energy density and poor efficiency at elevated temperatures, which constrains their use in the harsh-environment electronic devices, circuits, and systems.
Chao Yuan, Yao Zhou, Yujie Zhu, Jiajie Liang, Shaojie Wang, Simin Peng, Yushu Li, Sang Cheng, Mingcong Yang, Jun Hu, Bo Zhang, R. Zeng, Jinliang He, Qi Li   +13 more
semanticscholar   +1 more source

Next‐generation proteomics improves lung cancer risk prediction

Molecular Oncology, EarlyView.
This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj, Clara Frick, Ben Schöttker, Bernd Holleczek, Hermann Brenner   +4 more
wiley   +1 more source

Segmented multiblock polyolefin compatibilizers from non-living metathesis chain-shuffling

Nature Communications
The mechanical properties of mixed plastics can be enhanced by block copolymer compatibilizer additives. Here we report a series of semi-crystalline/semi-crystalline linear multiblock copolymers of LLDPE and PP, the two most abundant plastics, from a non-
Abhishek Banerjee, Navin Kafle, Walter G. Romano, Harsh Pandya, Shin Horiuchi, Aarushi Srivastava, Fardin Khabaz, Mark D. Foster, Toshikazu Miyoshi, James M. Eagan   +9 more
doaj   +1 more source

Conductividad iónica en nuevos compositos (PEO)10(CF3COONa)-X % Al2O3 [PDF]

Universitas Scientiarum, 2013
To increase the ionic conductivity of solid polymer electrolyte, (PEO)10CF3COONa, we formed new composites by adding alumina particles as a filler.
Nori Jurado Meneses, Miguel Iban Delgado Rosero, Ruben Antonio Vargas Zapata   +2 more
doaj   +1 more source

Pore-blockade Times for Field-Driven Polymer Translocation [PDF]

, 2008
We study pore blockade times for a translocating polymer of length $N$, driven by a field $E$ across the pore in three dimensions. The polymer performs Rouse dynamics, i.e., we consider polymer dynamics in the absence of hydrodynamical interactions.
Akeson M, de Gennes P-G, Debabrata Panja, Dreiseikelmann B, Dubbeldam J L A, Gerard T Barkema, Henk Vocks, Metzler R, Nakane J J, Panja D, Panja D, Panja D, Panja D Barkema G T, Panja D Barkema G T Ball R C, Panja D Barkema G T Ball R C, Robin C Ball, Szabò I   +16 more
core   +2 more sources