Results 31 to 40 of about 273,624 (301)

The role of histone modifications in transcription regulation upon DNA damage

FEBS Letters, EarlyView.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Types of Crosslinkers and Their Applications in Biomaterials and Biomembranes

Chemistry
Biomaterials and biomembranes play a crucial role in a variety of applications, particularly in the medical field due to their ability to mimic natural biological structures and functions.
Paolo Yammine, Ali El Safadi, Rima Kassab, Hanna El-Nakat, Pierre J. Obeid, Zeina Nasr, Tony Tannous, Nouha Sari-Chmayssem, Agapy Mansour, Ayman Chmayssem   +9 more
doaj   +1 more source

Next‐generation proteomics improves lung cancer risk prediction

Molecular Oncology, EarlyView.
This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj, Clara Frick, Ben Schöttker, Bernd Holleczek, Hermann Brenner   +4 more
wiley   +1 more source

Recent Developments in Functional Polymers via the Kabachnik–Fields Reaction: The State of the Art

Molecules
Recently, multicomponent reactions (MCRs) have attracted much attention in polymer synthesis. As one of the most well-known MCRs, the Kabachnik–Fields (KF) reaction has been widely used in the development of new functional polymers.
Rui Yuan, Xianzhe He, Chongyu Zhu, Lei Tao   +3 more
doaj   +1 more source

Adhesives: Polymer Chemistry at Work

CHIMIA, 2008
Successful adhesive technology relies on the diligent engineering of adhesive and cohesive forces. Polymers thereby play the dominant role as they largely determine the chemical and physical properties of the adhesive joint.
Christof Arz, Andreas Dobmann, Olaf Meincke, Adrian Schulthess, Willi Schwotzer   +4 more
doaj   +1 more source

Development and single‐particle analysis of hybrid extracellular vesicles fused with liposomes using viral fusogenic proteins

FEBS Open Bio, 2022
Extracellular vesicles (EVs) have potential biomedical applications, particularly as a means of transport for therapeutic agents. There is a need for rapid and efficient EV‐liposome membrane fusion that maintains the integrity of hybrid EVs.
Raga Ishikawa, Shosuke Yoshida, Shin‐ichi Sawada, Yoshihiro Sasaki, Kazunari Akiyoshi   +4 more
doaj   +1 more source

NIR-activated nanosystems with self-modulated bacteria targeting for enhanced biofilm eradication and caries prevention

Bioactive Materials, 2022
The efficacious delivery of antimicrobial drugs to intractable oral biofilms remains a challenge due to inadequate biofilm penetration and lack of pathogen targeting.
Yunjian Yu, Yufei Zhang, Yijie Cheng, Yuxia Wang, Zeyuan Chen, Haonan Sun, Xiaosong Wei, Zhuang Ma, Jie Li, Yayun Bai, Zhongming Wu, Xinge Zhang   +11 more
doaj   +1 more source