Results 71 to 80 of about 3,102,971 (378)

Autophagy in cancer and protein conformational disorders

FEBS Letters, EarlyView.
Autophagy plays a crucial role in numerous biological processes, including protein and organelle quality control, development, immunity, and metabolism. Hence, dysregulation or mutations in autophagy‐related genes have been implicated in a wide range of human diseases.
Sergio Attanasio
wiley   +1 more source

A stepwise emergence of evolution in the RNA world

FEBS Letters, EarlyView.
How did biological evolution emerge from chemical reactions? This perspective proposes a gradual scenario of self‐organization among RNA molecules, where catalytic feedback on random mixtures plays the central role. Short oligomers cross‐ligate, and self‐assembly enables heritable variations. An event of template‐externalization marks the transition to
Philippe Nghe
wiley   +1 more source

Barbier Self-Condensing Ketyl Polymerization-Induced Emission: A Polarity Reversal Approach to Reversed Polymerizability

iScience, 2020
Summary: Carbon-carbon bond formation through polarity reversal ketyl radical anion coupling of carbonyls has inspired new reaction modes to this cornerstone carbonyl group and played significant roles in organic chemistry.
Shun-Shun Li, Nengbo Zhu, Ya-Nan Jing, Yajun Li, Hongli Bao, Wen-Ming Wan   +5 more
doaj  

Flexible fiber batteries for applications in smart textiles

, 2013
Here we discuss two alternative approaches for building flexible batteries for applications in smart textiles. The first approach uses well-studied inorganic electrochemistry (Al-NaOCl galvanic cell) and innovative packaging in order to produce batteries
Bourgeois, Jean-Pierre, Gohy, Jean-François, Qu, Hang, Rolland, Julien, Skorobogatiy, Maksim, Vlad, Alexandru   +5 more
core   +1 more source

Cellular liquid biopsy provides unique chances for disease monitoring, preclinical model generation and therapy adjustment in rare salivary gland cancer patients

Molecular Oncology, EarlyView.
We quantified and cultured circulating tumor cells (CTCs) of 62 patients with various cancer types and generated CTC‐derived tumoroid models from two salivary gland cancer patients. Cellular liquid biopsy‐derived information enabled molecular genetic assessment of systemic disease heterogeneity and functional testing for therapy selection in both ...
Nataša Stojanović Gužvić, Florian Lüke, Steffi Treitschke, Andrea Coluccio, Martin Hoffmann, Giancarlo Feliciello, Adithi Ravikumar Varadarajan, Xin Lu, Kathrin Weidele, Catherine Botteron, Silvia Materna–Reichelt, Felix Keil, Katja Evert, Florian Weber, Thomas Schamberger, Michael Althammer, Jirka Grosse, Dirk Hellwig, Christian Schulz, Stephan Seitz, Peter Ugocsai, Anke Schlenska‐Lange, Roman Mayr, Ulrich Kaiser, Wolfgang Dietmaier, Bernhard Polzer, Jens Warfsmann, Kamran Honarnejad, Tobias Pukrop, Daniel Heudobler, Christoph A. Klein, Christian Werno   +31 more
wiley   +1 more source

Universal Sequence Replication, Reversible Polymerization and Early Functional Biopolymers: A Model for the Initiation of Prebiotic Sequence Evolution [PDF]

PLoS ONE (2012) 7 (4): e34166, 2012
Many models for the origin of life have focused on understanding how evolution can drive the refinement of a preexisting enzyme, such as the evolution of efficient replicase activity. Here we present a model for what was, arguably, an even earlier stage of chemical evolution, when polymer sequence diversity was generated and sustained before, and ...
arxiv   +1 more source

Straightforward synthesis of functionalized cyclic polymers in high yield via RAFT and thiolactone-disulfide chemistry [PDF]

, 2013
An efficient synthetic pathway toward cyclic polymers based on the combination of thiolactone and disulfide chemistry has been developed. First, heterotelechelic linear polystyrene (PS) containing an alpha-thiolactone (TLa) and an omega-dithiobenzoate ...
Baba, Eisuke, Du Prez, Filip, Espeel, Pieter, Stamenović, Milan M., Tezuka, Yasuyuki, Yamamoto, Takuya   +5 more
core   +1 more source

CircCCNB1 inhibits vasculogenic mimicry by sequestering NF90 to promote miR‐15b‐5p and miR‐7‐1‐3p processing in nasopharyngeal carcinoma

Molecular Oncology, EarlyView.
CircCCNB1 expression is down‐regulated in nasopharyngeal carcinoma (NPC); thus, less NF90 protein is bound to circCCNB1 and more binds to pri‐miRNAs, blocking their (pri‐miRNAs) binding to DGCR8 and inhibiting the processing and generation of miR‐15b‐5p/miR‐7‐1‐3p. Furthermore, decreased miR‐15b‐5p/miR‐7‐1‐3p promotes the expression of the target genes
Chunmei Fan, Fenghua Tan, Jie Wu, Zhaoyang Zeng, Wenjia Guo, He Huang, Wei Xiong   +6 more
wiley   +1 more source

Can Polymer Coils be modeled as "Soft Colloids"? [PDF]

Phys. Rev. Lett. 85, 2522 (2000), 2000
We map dilute or semi-dilute solutions of non-intersecting polymer chains onto a fluid of ``soft'' particles interacting via a concentration dependent effective pair potential, by inverting the pair distribution function of the centers of mass of the initial polymer chains.
arxiv   +1 more source

Synthesis of anthraquinone based electroactive polymers: A critical review [PDF]

, 2019
Conducting polymers or synthetic monomers have revolutionized the world and are at the heart of scientific research having a scope of vast diverse applications in many technological fields.
Abas, Abruña, Alici, Bar-Cohen, Bar-Cohen, Bitenc, Brunmark, Bu, Canepa, Cao, Carpi, Chen, Choi, Cui, Deng, Ding, Díaz, Esteves, Fannir, Feijen, Gazotti, Geng, Gracia, Guarino, Ha, Hernández, Hsiao, Hsiao, Häupler, Häupler, Inzelt, Iordache, Jean-Mistral, Jing, Juvenal, Kamogawa, Karlsson, Kawai, Lallart, Laurent, Li, Liang, Lin, Malik, Milczarek, Moss, Motokuni, Murty, Murty, Naoi, Oyaizu, Palaniappan, Pan, Pandith, Prakash, Price, Qiu, Radha, Salabert, Schmidt, Schmidt, Seidel, Sertkol, Sharma, Simionescu, Skotheim, Son, Song, Song, Takalloo, Takeda, Tang, Tian, Tsuzaki, Wagner, Wang, Wang, Waterlot, Xu, Xu, Yao, Zeng, Zhang, Zhao, Zheng, Zhou   +85 more
core   +2 more sources