Results 11 to 20 of about 1,891,612 (343)
Biophysical Chemistry, 2011 Molecular motors can exhibit Brownian ratchet or power stroke mechanisms. These mechanistic categories are related to transition state position: An early transition state suggests that chemical energy is stored and then released during the step (stroke) while a late transition state suggests that the release of chemical energy rectifies thermally ...
Galburt, E., Parrondo, J., Grill, S.
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International Journal of Molecular Sciences, 2019 Maintenance of genome integrity is a key process in all organisms. DNA polymerases (Pols) are central players in this process as they are in charge of the faithful reproduction of the genetic information, as well as of DNA repair. Interestingly, all eukaryotes possess a large repertoire of polymerases.
Pedroza-Garcia, Jose-Antonio +2 more
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Characteristics of Pan-Cancer Patients With Ultrahigh Tumor Mutation Burden
Frontiers in Oncology, 2021 BackgroundTumor mutation burden has been proven to be a good predictor for the efficacy of immunotherapy, especially in patients with hypermutation. However, most research focused on the analysis of hypermutation in individual tumors, and there is a lack
Hong Yuan +13 more
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RNA Polymerases of Maize: Nuclear RNA Polymerases [PDF]
Proceedings of the National Academy of Sciences, 1971 Two DNA-dependent RNA polymerases of nuclear origin have been purified from leaves of Zea mays . The two enzymes can be separated on DEAE-cellulose columns. Enzymes I and II are eluted with 0.08 and 0.20 M (NH 4 ) 2 SO 4 , respectively.
G C, Strain, K P, Mullinix, L, Bogorad
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Mechanism of SARS-CoV-2 polymerase stalling by remdesivir
Nature Communications, 2021 Remdesivir is the only FDA-approved drug for the treatment of COVID-19 patients. The active form of remdesivir acts as a nucleoside analog and inhibits the RNA-dependent RNA polymerase (RdRp) of coronaviruses including SARS-CoV-2.
G. Kokic +9 more
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International Journal of Neonatal Screening, 2021 A variant in the POLG gene is the leading cause of a heterogeneous group of mitochondrial disorders. No definitive treatment is currently available. Prenatal and newborn screening have the potential to improve clinical outcome of patients affected with ...
Kanokwan Sriwattanapong +5 more
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Primer-BLAST: A tool to design target-specific primers for polymerase chain reaction
BMC Bioinformatics, 2012 Choosing appropriate primers is probably the single most important factor affecting the polymerase chain reaction (PCR). Specific amplification of the intended target requires that primers do not have matches to other targets in certain orientations and ...
Jian Ye +5 more
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Structure and Function of Caliciviral RNA Polymerases
Viruses, 2017 Caliciviruses are a leading agent of human and animal gastroenteritis and respiratory tract infections, which are growing concerns in immunocompromised individuals. However, no vaccines or therapeutics are yet available.
Ji-Hye Lee +2 more
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Structure of the RNA-dependent RNA polymerase from COVID-19 virus
Science, 2020 The COVID-19 RNA-synthesizing machine Many in the scientific community have mobilized to understand the virus that is causing the global coronavirus disease 2019 (COVID-19) pandemic. Gao et al.
Yan Gao +27 more
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Functional Insights into ANP32A-Dependent Influenza A Virus Polymerase Host Restriction
Cell Reports, 2017 Host restriction of influenza A virus limits pandemic emergence. The viral RNA polymerase (vPol) is an essential enzyme that must adapt for avian viruses to replicate in humans. Species differences in host ANP32A dictate adaptation: human ANP32A lacks an
Patricia Domingues, Benjamin G. Hale
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