Results 261 to 270 of about 1,254,897 (274)

Structural basis for intrinsic strand displacement activity of mitochondrial DNA polymerase. [PDF]

Nat Commun
Nayak AR, Sokolova V, Sillamaa S, Herbine K, Sedman J, Temiakov D.   +5 more
europepmc   +1 more source

Dynamics of Cell Fate Decisions during Chemically Induced Multi‐Lineage Trans‐Differentiation at Single‐Cell Level

Advanced Science, EarlyView.
A critical aspect of chromosomal remodeling in small molecule‐induced multilineage trans‐differentiation(iMT) is elucidated. A dynamic atlas spanning over 35 days profiles terminal trans‐differentiated cells, which reverted to a more youthful state. This study reveals parallels between iMT and other cell fate determination processes, emphasizing an ...
Weigao E, Lijiang Fei, Jingjing Wang, Xinru Wang, Renying Wang, Xueyi Wang, Peijing Zhang, Jianhui Chen, Junqing Wu, Mengmeng Jiang, Daosheng Huang, Danmei Jia, Guoji Guo, Xiaoping Han   +13 more
wiley   +1 more source

Precision-edited histone tails disrupt polycistronic gene expression controls in trypanosomes

Novotná M, Tinti M, Faria JRC, Horn D.
europepmc   +1 more source

Bi-allelic variants in BRF2 are associated with perinatal death and craniofacial anomalies. [PDF]

Genome Med
Mattioli F, Friðriksdóttir R, Hebert A, Bassani S, Ibrahim N, Naz S, Chrast J, Pailler-Pradeau C, Oddsson Á, Sulem P, Halldorsson GH, Melsted P, Guðbjartsson DF, Palombo F, Pippucci T, Nouri N, Seri M, Farrow EG, Saunders CJ, Guex N, Ansar M, Stefansson K, Reymond A.   +22 more
europepmc   +1 more source

The Reconstruction of Peripheral Auditory Circuit: Recent Advances and Future Challenges

Advanced Science, EarlyView.
This paper summarizes the potential of biomaterials, stem cells, and gene editing technologies in the regeneration of inner ear hair cells, spiral ganglion neurons, and inner ear organoids. Challenges and potential developments are discussed and explored.
Zhe Li, Ying Zhang, Zhenyu Xiao, Jieyu Qi   +3 more
wiley   +1 more source

Presenting Symptoms and Delayed Diagnosis of Ehrlichiosis. [PDF]

Mayo Clin Proc Innov Qual Outcomes
Murawska Baptista A, Kaminska A, Gorasevic M, Alvarez S, Gnanapandithan K, Gavrancic T, Smerina M, Dumitrascu AG, Cortes MP, Pagan RJ, Singla A.   +10 more
europepmc   +1 more source

Targeting Replication Fork Processing Synergizes with PARP Inhibition to Potentiate Lethality in Homologous Recombination Proficient Ovarian Cancers

Advanced Science, EarlyView.
This study demonstrates that the resveratrol analogue, trans‐4,4′‐dihydroxystilbene (DHS), exhibits synergistic anti‐tumor activity with the PARP inhibitor talazoparib, inducing significant ovarian cancer cell death. The synergistic effect of this combination arises from the concurrent downregulation of homologous recombination factors and the ...
Ganesh Pai Bellare, Kshama Kundu, Papiya Dey, Krupa Thankam Philip, Nitish Chauhan, Muskan Sharma, Sankarsingh Kesharsingh Rajput, Birija Sankar Patro   +7 more
wiley   +1 more source

Molecular basis for the interaction between Saccharomyces cerevisiae Rtt103 and the Rat1-Rai1 complex. [PDF]

Nat Commun
Chu HF, Tong L.
europepmc   +1 more source

Exonuclease-III Assisted Signal Cycle Integrating with Self-Priming Mediated Chain Extension for Sensitive and Reliable MicroRNA Detection. [PDF]

ACS Omega
Li C, Zheng X, Xie S, Lin D.
europepmc   +1 more source

Structural basis of error-prone DNA synthesis by DNA polymerase θ. [PDF]

Nat Commun
Li C, Maksoud LM, Gao Y.
europepmc   +1 more source