Results 21 to 30 of about 1,254,897 (274)
Viruses, 2023 The human respiratory syncytial virus (RSV) is a negative-sense, single-stranded RNA virus. It is the major cause of severe acute lower respiratory tract infection in infants, the elderly population, and immunocompromised individuals.
Priscila Sutto-Ortiz +3 more
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Viruses, 2020 The Eurasian avian-like swine (EA) H1N1 virus has affected the Chinese swine industry, and human infection cases have been reported occasionally. However, little is known about the pathogenic mechanism of EA H1N1 virus.
Mengkai Cai +10 more
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Kinetics and thermodynamics of exonuclease-deficient DNA polymerases [PDF]
Phys. Rev. E 93, 042419 (2016), 2016 A kinetic theory is developed for exonuclease-deficient DNA polymerases, based on the experimental observation that the rates depend not only on the newly incorporated nucleotide, but also on the previous one, leading to the growth of Markovian DNA sequences from a Bernoullian template. The dependences on nucleotide concentrations and template sequence
arxiv +1 more source
Viruses, 2023 Background: As long as COVID-19 endures, viral surface proteins will keep changing and new viral strains will emerge, rendering prior vaccines and treatments decreasingly effective.
Brittany A. Comunale +5 more
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Kinetics and thermodynamics of DNA polymerases with exonuclease proofreading [PDF]
Phys. Rev. E 93, 042420 (2016), 2016 Kinetic theory and thermodynamics are applied to DNA polymerases with exonuclease activity, taking into account the dependence of the rates on the previously incorportated nucleotide. The replication fidelity is shown to increase significantly thanks to this dependence at the basis of the mechanism of exonuclease proofreading.
arxiv +1 more source
International Journal of Neonatal Screening, 2021 A variant in the POLG gene is the leading cause of a heterogeneous group of mitochondrial disorders. No definitive treatment is currently available. Prenatal and newborn screening have the potential to improve clinical outcome of patients affected with ...
Kanokwan Sriwattanapong +5 more
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Accuracy and speed of elongation in a minimal model of DNA replication [PDF]
, 2021 Being a dual purpose enzyme, the DNA polymerase is responsible for elongation of the newly formed DNA strand as well as cleaving the erroneous growth in case of a misincorporation. The efficiency of replication depends on the coordination of the polymerization and exonuclease activity of DNA polymerase.
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Identification of a New Ribonucleoside Inhibitor of Ebola Virus Replication
Viruses, 2015 The current outbreak of Ebola virus (EBOV) in West Africa has claimed the lives of more than 15,000 people and highlights an urgent need for therapeutics capable of preventing virus replication.
Olivier Reynard +5 more
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Beyond the Lesion: Back to High Fidelity DNA Synthesis
Frontiers in Molecular Biosciences, 2022 High fidelity (HiFi) DNA polymerases (Pols) perform the bulk of DNA synthesis required to duplicate genomes in all forms of life. Their structural features, enzymatic mechanisms, and inherent properties are well-described over several decades of research.
Joseph D. Kaszubowski +1 more
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Efficient fidelity control by stepwise nucleotide selection in polymerase elongation [PDF]
Mol. Based Math. Biol. 2014, 2,141, 2014 Polymerases select nucleotides before incorporating them for chemical synthesis during gene replication or transcription. How the selection proceeds stepwise efficiently to achieve sufficiently high fidelity and speed is essential for polymerase function. We examined step-by-step selections that have conformational transition rates tuned one at time in
arxiv +1 more source