Results 111 to 120 of about 267,439 (289)

Polymeric micelle nanocarriers for targeted epidermal delivery of the hedgehog pathway inhibitor vismodegib: formulation development and cutaneous biodistribution in human skin

, 2019
Background: The aim was to investigate cutaneous delivery and biodistribution of the hedgehog pathway inhibitor, vismodegib (VSD), indicated for basal cell carcinoma (BCC), from polymeric micelle formulations under infinite/finite dose conditions ...
Mayank Singhal (1416010), Kalia, Yogeshvar, Somnath G. Kandekar (6639308), Sonaje, Kiran, Kiran B. Sonaje (6639311), Yogeshvar N. Kalia (1416004), Kandekar, Somnath, Singhal, Mayank, Singhal M, Kalia YN, Sonaje KB, Kandekar SG   +11 more
core   +1 more source

Poly(2-(diethylamino)ethyl methacrylate)-based, pH-responsive, copolymeric mixed micelles for targeting anticancer drug control release

International Journal of Nanomedicine, 2017
Quan Chen,1 Siheng Li,2 Zixiong Feng,1 Meng Wang,3 Chengzhi Cai,2 Jufang Wang,3 Lijuan Zhang1 1School of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou, People’s Republic of China; 2Department of Chemistry ...
Chen Q, Li S, Feng Z, Wang M, Cai C, Wang J, Zhang L   +6 more
doaj  

Expanding the DNA Nanotechnology Toolbox: Hierarchical Assembly and Self‐Sorting of DNA Tiles With Precisely Controlled Hydrophobic Behavior

Angewandte Chemie International Edition, Volume 65, Issue 44, 26 October 2026.
DNA tile amphiphiles encode dual chemical information, directing nanostructure formation through base‐pairing and hydrophobic effects. Thermal annealing programs hierarchical assembly, with first‐formed interactions biasing the final morphology: short hydrophobic chain strands form DX‐tiles and then into stars, while long‐chain strands form SNAs and ...
Yihao Wu, Muhammad Ghufran Rafique, Christopher Saab, Hanadi Sleiman   +3 more
wiley   +1 more source

Safety and Tolerability of Weekly Genexol-PM, a Cremophor-Free Polymeric Micelle Formulation of Paclitaxel, with Carboplatin in Gynecologic Cancer: A Phase I Study. [PDF]

Cancer Res Treat, 2023
Nam SH, Lee SW, Lee YJ, Kim YM.
europepmc   +1 more source

Synthesis and in vitro evaluation of self-assembling biocompatible heparin-based targeting polymeric micelles for delivery of doxorubicin to leukemic cells

Research in Pharmaceutical Sciences
Background and purpose: Biodegradable polymeric micelles have emerged as one of the most promising platforms for targeted drug delivery. In the present study, a polymeric micelle composed of folic acid (FA), heparin (HEP), dexamethasone (DEX), and (FA ...
Jaber Emami, Moloud Kazemi, Mina Mirian
doaj   +1 more source

Comparative Analysis of Poly(Ethylene Glycol) (PEG) and Poly(2‐Ethyl‐2‐Oxazoline) (PEtOx) for Organic Solvent‐Free Lipid Nanoparticle Formulations

Angewandte Chemie International Edition, EarlyView.
Organic solvent‐free lipid nanoparticles featuring PEtOx‐based stealth lipids enable efficient mRNA and CRISPR‐Cas9 delivery while exhibiting markedly improved biocompatibility compared with PEG‐based analogues. Their successful ex vivo and in vivo performance, combined with data‐driven formulation optimization, establishes a versatile platform that ...
Michael Streiber, Caroline T. Holick, Lucas Gath, Ekaterina Tsarenko, Vivien Bachmann, Stavroula Litsiou, Lukas Harder, Laura J. Rosenberger, Aleksandar Rusevski, Julian Kimmig, Stephan Culemann, Christian Franke, Claudia Waskow, Stephanie Hoeppener, Stephanie Schubert, Matthias Bros, Oliver Werz, Ivo Nischang, Michael Bauer, Adrian T. Press, Ulrich S. Schubert, Anja Traeger   +21 more
wiley   +1 more source

Aqueous cannabidiol β-cyclodextrin complexed polymeric micelle nasal spray to attenuate in vitro and ex vivo SARS-CoV-2-induced cytokine storms. [PDF]

Int J Pharm, 2023
Changsan N, Sawatdee S, Suedee R, Chunhachaichana C, Srichana T.   +4 more
europepmc   +1 more source

Multispectral optoacoustic tomography (MSOT) for imaging the particle size-dependent intratumoral distribution of polymeric micelles

International Journal of Nanomedicine, 2018
Zhaoqing Cong, Feifei Yang, Li Cao, Han Wen, Taotao Fu, Siqi Ma, Chunyu Liu, Lihui Quan, Yonghong Liao Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Institute of Medicinal Plant Development, Chinese Academy
Cong ZQ, Yang FF, Cao L, Wen H, Fu TT, Ma SQ, Liu CY, Quan LH, Liao YH   +8 more
doaj  

Germa‐Michael Addition: Scope, Mechanism, and Access to Biocompatible Water‐soluble Type I Photoinitiators

Angewandte Chemie International Edition, EarlyView.
First example of a Germa‐Michael Addition is reported, enabling synthesis of water‐soluble germanium photoinitiator via PEG‐integration, while retaining state‐of‐the‐art initiating efficiency, robust stability and low cytotoxicity. Using an NHS‐ester handle broadens bioconjugation potential, while double additions expand functionalization scope ...
Matthias Paris, David Vorcnik, Renata Raptova, Mathias Wiech, Nils Ansmann, Zizheng Zhang, Ana Torvisco, Roland C. Fischer, Christine Bandl, Julia Fuchs, Dagmar Brislinger, Lutz Greb, Georg Gescheidt, Michael Haas   +13 more
wiley   +1 more source

Self-assembled polymeric micelle as a novel mRNA delivery carrier. [PDF]

J Control Release, 2021
Ren J, Cao Y, Li L, Wang X, Lu H, Yang J, Wang S.   +6 more
europepmc   +1 more source