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Polymeric Micelles for Anticancer Drug Delivery
Therapeutic Delivery, 2020Polymeric micelles have gained interest as novel drug delivery systems for the treatment and diagnosis of cancer, as they offer several advantages over conventional drug therapies. This includes drug targeting to tumor tissue, in vivo biocompatibility and biodegradability, prolonged circulation time, enhanced accumulation, retention of the drug loaded ...
Nairrita Majumder +2 more
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Polymerization of Anionic Wormlike Micelles
Langmuir, 2005Polymerizable anionic wormlike micelles are obtained upon mixing the hydrotropic salt p-toluidine hydrochloride (PTHC) with the reactive anionic surfactant sodium 4-(8-methacryloyloxyoctyl)oxybenzene sulfonate (MOBS). Polymerization captures the cross-sectional radius of the micelles (approximately 2 nm), induces micellar growth, and leads to the ...
Zhiyuan, Zhu +4 more
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Polymeric micelles in oral chemotherapy
Journal of Controlled Release, 2008Oral administration of anticancer agents is preferred by patients for its convenience and potential for use in outpatient and palliative setting. In addition, oral administration facilitates a prolonged exposure to the cytotoxic agents. Enhancement of bioavailability of emerging cytotoxic agents is a pre-requisite for successful development of oral ...
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Polymeric micelles for oral drug delivery
European Journal of Pharmaceutics and Biopharmaceutics, 2010In the case of chronic therapies, the oral route is often the preferred route for drug administration given its acceptability and convenience. However, various factors which limit drug absorption through the gastro-intestinal (GI) mucosa contribute to restricting the bioavailability of the drug, that is, the actual amount which reaches the bloodstream.
Geneviève, Gaucher +4 more
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Polymeric Micelle as Multifunctional Pharmaceutical Carriers
Journal of Nanoscience and Nanotechnology, 2014A number of formulations have been developed and reported in literature as a carrier for drug, gene, and diagnostic agents. Amphiphilic block copolymers have achieved increasing attention due to their high stability both in vitro and in vivo and their good biocompatibility. In comparison to other long-circulating nanocarriers, micelles possess a number
Girish, Kore +3 more
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Super pH-Sensitive Multifunctional Polymeric Micelle
Nano Letters, 2005To endow enhanced tumor specificity and endosome disruption property on the carrier, a multifunctional polymeric micelle was investigated. The micelle exposes the cell interacting ligand (biotin) on the surface under slightly acidic environmental conditions of various solid tumors and is internalized by biotin receptor-mediated endocytosis in a short ...
Eun Seong, Lee, Kun, Na, You Han, Bae
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Colloid Journal, 2010
Polymerized and nonpolymerized micelles of N-acryloyl-11-aminoundecanoic acid and its sodium salt in water and dimethylformamide are studied by viscometry, isothermal diffusion, and dynamic light scattering. It is revealed that the hydrodynamic sizes of polymerized micelles (PMs) obtained via polymerization of the surfactants in aqueous solutions at ...
A. B. Mel’nikov +4 more
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Polymerized and nonpolymerized micelles of N-acryloyl-11-aminoundecanoic acid and its sodium salt in water and dimethylformamide are studied by viscometry, isothermal diffusion, and dynamic light scattering. It is revealed that the hydrodynamic sizes of polymerized micelles (PMs) obtained via polymerization of the surfactants in aqueous solutions at ...
A. B. Mel’nikov +4 more
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Reverse polymeric micelles for pharmaceutical applications
Journal of Controlled Release, 2008Star-shaped (4- to 8-arms) and linear poly(glycidyl methacrylate)s were synthesized by atom transfer radical polymerization as precursors of poly(glycerol methacrylate)s (PG(OH)MAs). The water-soluble PG(OH)MA backbones were modified through the esterification of pendant hydroxyl functions with acyl chlorides (12 to 18 carbons). Alkyated PG(OH)MAs were
Marie-Christine, Jones +2 more
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Synthesis of Photolabile Fluorescent Polymeric Micelles
Journal of Nanoscience and Nanotechnology, 2014A new amphiphilic block copolymers were synthesized with the atom transfer radical polymerization (ATRP) method. Then, the micelle structures were fabricated with a self-assembly method for application in nanocarriers and sensing. The fluorescent intensity was increased by a factor of 4 in the micelle solution due to more stacked pyrene moieties.
Teahoon, Park +3 more
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Polymerization of Rodlike Micelles
Langmuir, 1999A new polymerizable surfactant, cetyltrimethylammonium 4-vinylbenzoate (CTVB), has been prepared and investigated. In aqueous solution, highly entangled rodlike aggregates are formed at millimolar surfactant concentrations. Free-radical polymerization of the surfactant counterions results in nearly complete conversion to a stable, nonviscous solution ...
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