Results 61 to 70 of about 277,094 (244)

Engineering Immunoregenerative Therapy via an Immunomodulatory Binary Pharmacology Hydrogel Depot for Prolonged Allograft Survival

Advanced Science, EarlyView.
An immunomodulatory hydrogel (iGEL) forms spontaneously upon subcutaneous injection, acting as a tissue‐adhesive depot. It releases anti‐rejection and regenerative agents in response to inflammation, suppressing T‐cell activity, promoting vascular repair, and restoring allograft function without systemic immunosuppression.
Ning Wang, Ruiqi Sun, Yang Fu, Zhonghan Wu, Xinyu Tong, Hong Tang, Wentao Zhao, Zhi Liang, Jintao Zheng, Yanan Guan, Ke Zhou, Penghong Song, Shusen Zheng, Hangxiang Wang, Haiyang Xie   +14 more
wiley   +1 more source

Redox-sensitive polymeric micelles with aggregation-induced emission for bioimaging and delivery of anticancer drugs

Journal of Nanobiotechnology, 2021
Background Nano-drug delivery systems show considerable promise for effective cancer therapy. Polymeric micelles have attracted extensive attention as practical nanocarriers for target drug delivery and controlled drug delivery system, however, the ...
Changzhen Sun, Ji Lu, Jun Wang, Ping Hao, Chunhong Li, Lu Qi, Lin Yang, Bin He, Zhirong Zhong, Na Hao   +9 more
doaj   +1 more source

Celastrol‐Loaded Conductive Hydrogel Mitigates Myocardial Ischemia‐Reperfusion Injury and Restores Electrophysiological Function

Advanced Science, EarlyView.
Schematic illustration of the Pluronic F127 diacrylate/gelatin methacryloyl/poly(3,4‐ethylenedioxythiophene):poly(styrenesulfonate)/celastrol hydrogel (FGPC) for localized myocardial ischemia–reperfusion injury treatment. FGPC combines sustained celastrol delivery with PEDOT:PSS‐mediated conductive support to attenuate acute oxidative/inflammatory ...
Shixin Wang, Shaojie Chen, Chengzong Li, Hongyi Cheng, Jincheng Jiao, Xiafeng Peng, Yike Zhang, Wei Sun, Feng Zhang, Chang Cui, Minglong Chen   +10 more
wiley   +1 more source

pH-responsive polymeric micelles with core–shell–corona architectures as intracellular anti-cancer drug carriers

Science and Technology of Advanced Materials, 2013
Polymeric micelles with core–shell–corona nanoarchitecture were designed for intracellular therapeutic anti-cancer drug carriers. Poly(styrene-b-acrylic acid-b-ethylene glycol) (PS-b-PAA-b-PEG) asymmetric triblock copolymer underwent self-assembly in ...
Bishnu Prasad Bastakoti, Shih-Hsiang Liao, Masamichi Inoue, Shin-Ichi Yusa, Masataka Imura, Kenichi Nakashima, Kevin C-W Wu and Yusuke Yamauchi
doaj   +1 more source

Permeability of Ciprofloxacin-Loaded Polymeric Micelles Including Ginsenoside as P-glycoprotein Inhibitor through a Caco-2 Cells Monolayer as an Intestinal Absorption Model

Molecules, 2018
The low oral bioavailability of ciprofloxacin is associated with two distinct challenges: its low aqueous solubility and efflux by p-glycoproteins (P-gp) in the intestinal membrane.
Behzad Sharif Makhmal Zadeh, Golbarg Esfahani, Anayatollah Salimi   +2 more
doaj   +1 more source

Biodistribution and Activity of EFGR Targeted Polymeric Micelles Delivering a New Inhibitor of DNA Repair to Orthotopic Colorectal Cancer Xenografts with Metastasis

, 2022
The disruption of polynucleotide kinase/phosphatase (PNKP) in colorectal cancer (CRC) cells deficient in phosphatase and tensin homolog (PTEN) is expected to lead to the loss of cell viability by a process known as synthetic lethality.
Lavasanifar, Afsaneh, Amirhossein, Seyed, Soleimani, Amir Hasan, Paladino, Marco, Munira, Sirazum, de Paiva, Igor Moura, Dakhili, Tabatabaei, Hall, Dennis G., Weinfeld, Michael, Vakili, Mohammad Reza, Martin, Gary, Jirik, Frank R.   +11 more
core   +1 more source

Nanomaterials for Allergy Diagnosis and Treatment: Advances, Opportunities and Translational Challenges

Advanced Science, EarlyView.
Nanomaterials offer dual applications in allergy management. For diagnosis, nanomaterials enhance analytical sensitivity and improve detection in specific IgE and functional assays such as the basophil activation test (BAT). For allergen‐specific immunotherapy, nanomaterials enable allergen masking and controlled release, and effectively modulate the ...
Madiha Habib, Shan Jiang, Joyce ZX Lee, CW Lim, HL Yeung, Nicki YH Leung, Patrick SC Leung, Ting F Leung, Christine YY Wai   +8 more
wiley   +1 more source

Recent Advances in Carbon Cathode Materials toward High‐Performing Zinc‐Ion Hybrid Supercapacitors

Advanced Science, EarlyView.
Aqueous zinc‐ion hybrid supercapacitors (ZHSCs) have emerged as promising next‐generation electrochemical energy‐storage devices. Porous carbon materials have been extensively studied as cathodes, with advances in tailoring pore structures and material properties to enhance performance.
Take Hirooka, Zhaolin Liu, Ivan P. Parkin, Guanjie He   +3 more
wiley   +1 more source

Exploring Polymeric Micelles for Improved Delivery of Anticancer Agents: Recent Developments in Preclinical Studies

Pharmaceutics, 2013
As versatile drug delivery systems, polymeric micelles have demonstrated particular strength in solubilizing hydrophobic anticancer drugs while eliminating the use of toxic organic solvents and surfactants. However, the true promise of polymeric micelles
Wei Fan, Yingzhe Wang, Chalet Tan
doaj   +1 more source

An Efficient Detection Platform Based on Mesoporous Au@Cr2O3 Particles with Schwarz P Surface for Precise Periodontitis Metabolite Profiling

Advanced Science, EarlyView.
A non‐invasive periodontitis diagnosis platform was developed using Au nanoparticles‐decorated mesoporous Cr2O3 (Au@mCr2O3) particles with Schwarz P surface as matrix for saliva metabolic fingerprinting (SMFs) analysis via MALDI‐MS. With the assistance of machine learning of SMFs, this platform enables efficient diagnosis and the screening of potential
Yue Sun, Yan Wang, Fangying Shi, Wenhe Xie, Yiding Zhang, Heyuhan Zhang, Chunhui Deng, Limin Wu, Meihua Chen, Yonghui Deng   +9 more
wiley   +1 more source