Results 51 to 60 of about 482,977 (308)
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
, 2019 Polymerization-induced self-assembly via reversible addition–fragmentation transfer (RAFT)-mediated emulsion polymerization has served as a versatile platform for scalable preparation of well-defined block copolymer nanoparticles.
Yuxuan Zhang (1425721) +4 more
core +1 more source
FEBS Letters, EarlyView.We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace +6 more
wiley +1 more source
Three new Alpha1-Antitrypsin deficiency variants help to define a C-Terminal region regulating conformational change and polymerization [PDF]
, 2012 Alpha1-antitrypsin (AAT) deficiency is a hereditary disorder associated with reduced AAT plasma levels, predisposing adults to pulmonary emphysema.
Fra Anna M. +76 more
core +2 more sources
Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis
FEBS Letters, EarlyView.Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee +7 more
wiley +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
, 2017 Polymerization-induced cooperative assembly (PICA) is developed to promote morphological transitions at high solids via RAFT dispersion polymerization, using both a macromolecular chain transfer agent (macro-CTA) and a small molecule chain transfer agent
Xiaoqing Lv (1491601) +4 more
core +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Polymerization-Induced Self-Assembly of Conjugated Block Copoly(phenylacetylene)s
, 2020 Polymerization-induced self-assembly (PISA) was developed to prepare assemblies of conjugated block copoly(phenylacetylene)s for the first time. The living dispersion polymerization of (R/S)-4-(1-phenethylbamoyl)phenylacetylene (rmAN/smAN) can be ...
Junxian Chen (4114183) +5 more
core +1 more source
Inhibiting the Thermal Gelation of Copolymer Stabilized Nonaqueous Dispersions and the Synthesis of Full Color PMMA Particles [PDF]
, 2016 Polymeric particle dispersions have numerous potential applications; currently one of the most relevant is their use as inks in electrophoretic displays.
Simon J. Holder (1866523) +7 more
core +1 more source