Results 91 to 100 of about 2,563,144 (300)
Blood RNA Biomarker Signatures for Early Diagnosis and Prognosis in Ischemic and Hemorrhagic Stroke: The IBIS‐CT1 Study
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective
To evaluate the expression of nine blood RNA biomarkers in a clinical trial based on genes previously identified in an experimental monkey model of stroke for diagnosis feasibility and prognostication. Methods
IBIS‐CT1 was a prospective longitudinal study enrolling patients with ischemic stroke (IS) or intracerebral hemorrhage (ICH ...Salomé Retailleau, Marie Bruguet, Irina Viakhireva‐Dovganyuk, François‐Mathias Merrien, Denis Marechal, Aurore Jourdain, Philippe Goas, Jordan Coris, Julien Asselineau, Maëlys Consigny, Gérald Le Gac, Serge Timsit +11 morewiley +1 more sourceA non-synonymous coding change in the CYP19A1 gene Arg264Cys (rs700519) does not affect circulating estradiol, bone structure or fracture [PDF]
, 2011 Background
The biosynthesis of estrogens from androgens is catalyzed by aromatase P450 enzyme, coded by the CYP19A1 gene on chromosome 15q21.2. Genetic variation within the CYP19A1 gene sequence has been shown to alter the function of the enzyme.Mullin, B., Ingley Evan, Lewis, J., Evan Ingley, Wilson Scott G, McNab, Tegan, Jenny Z Wang, Wang, J., Wang, J.Z., Deogan, M.S., Prince, R.L., McNab Tegan J, Ben H Mullin, Chew Shelby, McNab, T.J., Chew, S., Wang Jenny Z, Mandeep S Deogan, Richard L Prince, Mullin Ben H, Scott G Wilson, Tegan J McNab, Lewis, J.R., Prince, R., Ingley, E., Prince Richard L, Deogan Mandeep S, Deogan, M., Wilson, S., Wilson, S.G., Mullin, B.H., Lewis Joshua R, Shelby Chew, Joshua R Lewis +33 morecore +2 more sourcesThe Comprehensive Live Cell‐Based Cytotoxicity Assay for Monitoring Disease Activity and Guiding Rescue Therapy in Acute Attacks of NMOSD
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective
Neuromyelitis optica spectrum disorder (NMOSD) is a devastating neurological disease that lacks serological biomarkers that can accurately reflect disease activity. We established a live cell‐based assay (LCBA) using serum with endogenous complement to quantify the overall cytotoxicity, offering a novel functional tool for monitoring Xiaona Xu, Jie Ding, Yupeng Du, Guibao Luo, Jinming Li, Rui Liu, Xiaoyi Xu, Xiao Li, Minshu Li, Wei Jiang, Chunsheng Yang +10 morewiley +1 more sourceGenetic Determinants of Serum Testosterone Concentrations in Men [PDF]
, 2011 Testosterone concentrations in men are associated with cardiovascular morbidity, osteoporosis, and mortality and are affected by age, smoking, and obesity.Frank H de Jong, Lyytikäinen LP, Vasan, Ramachandran S, Uitterlinden AG, Wichmann HE, Zhuang WV, Wu, TS, Liu, YM, Rivadeneira Ramirez, F. (Fernando), Lorentzon, M, Murray, A, Harris, Tamara B, Murray Anna, Tajar, A., Kähönen M, Lehtimäki Terho, Stolk, Lisette, Völzke Henry, Mellström, D, Wichmann, H.-E., Reincke, M, Kiel, D.P. (Douglas), Stolk Lisette, Robin Haring, Uitterlinden, Andre G., Bidlingmaier, M, David Karasik, Miljkovic, I, Ziv, E. (Elad), Penninx B, Coviello, A.D., Murabito Joanne M., Pye, SR, EMAS Study Group (), Ljunggren, Osten, Liu, Y, Murabito JM, Uitterlinden, André G, Perry, J.R., Karlsson, Magnus, Wallaschofski, H, Brenda Penninx, Murray, Anna, Ziv E, Lyytikäinen, Leo Pekka, Wallaschofski, H., Marcello Maggio, Perry, John R. B., Lunetta, Kathryn L., Vandenput Liesbeth, Frank H. de Jong, Wichmann, H.E. (Heinz Erich), Wu, Tsung-Sheng, John-Olov Jansson, Uitterlinden, AG, Haring, R., Hofman, A., Tamara B Harris, Koster A, Koster, A, Harris, T.B. (Tamara), Rivadeneira F, Karlsson, Magnus,, Voelker, Uwe, Lunetta, KL, Tamara B. Harris, Murray, A. (Anna), Lehtimäki, Terho (Tay), Heier, Margit, Eriksson, A., Melzer, D, Wu Tsung-Sheng, Miljkovic I, Ohlsson Claes, Rivadeneira, F, Bhasin, S, Murabito, J. (Joanne), Murray A, Petersen, A.K., Nauck, M., Pye, Stephen R., Vandenput, Liesbeth, Petersen AK, Ferrucci, L. (Luigi), Lunetta Kathryn L., Eriksson, A, Huhtaniemi Ilpo T., Eriksson, J, Penninx, B.W.J.H., Eriksson A, Ulloor Jagadish, Annemarie Koster, Kiel Douglas P., Hofman Albert, Abdelouahid Tajar, Reincke Martin, Eriksson J, Coviello, A.D, Nauck, Matthias, Koster, Annemarie, Kähönen Mika, Völker, U. (Uwe), Kiel, Douglas P., Tajar, A. (Abdelouahid), Ulloor, J, Kähönen, M, Wu, T.-S., Liu Y, Ohlsson, C, Melzer, David, Völzke, H. (Henry), Miljkovic, Iva, Mellström D, Nauck M, Perry JR, Frederick C. W. Wu, Iva Miljkovic, Reincke, M., De Jong, Frank H., Ulloor, J. (Jagadish), Wichmann, H. E., Dan Mellström, Nilsson Maria, Penninx Brenda, Fernando Rivadeneira, Frederick C W Wu, Eriksson, Anna-Lena,, Miljkovic, I. (Iva), Eriksson Anna, John R B Perry, Hammond, G.L., Jansson JO, Holliday, Kate L., Jansson, JO, Martin Reincke, Ohlsson, C. (Claes), Hammond GL, Pye, Stephen R, MAGGIO, Marcello Giuseppe, Ferrucci, L, Mellstrom, Dan, Murabito, Joanne M., Stolk, L., Nilsson, Maria, Maggio, Marcello, Ramachandran S Vasan, Harris TB, Wu Frederick C. W., Wu, Frederick C. W., Uitterlinden, A.G. (André), Heier, M, Lund University., Kate L. Holliday, Luigi Ferrucci, Douglas P Kiel, de Jong, Frank H, Coviello, AD, Nilsson, M. (Maria), Völzke, H, Haring R., Mika Kähönen, Uitterlinden, A. G., Hofman A, Tajar, Abdelouahid, Wallaschofski, Henri, Raitakari, O, Wu, F.C., Ferrucci Luigi, Vandenput L, Ljunggren, Östen,, Haring, R. (Robin), EMAS Study Group, Wu, FCW, Teumer, A., Joel Eriksson, Haring Robin, Zhuang, Wei Vivian, Hammond, Geoffrey L., Kiel, Douglas P, Nilsson, Maria,, Stephen R. Pye, Teumer, A, Perry, J.R.B. (John), Vasan, Ramachandran S., Matthias Nauck, Lyytikäinen, Leo-Pekka (Tay), Joanne M Murabito, Koster, A., Wu, F.C.W., Tajar, A, Jansson, John Olov, Petersen, Ann Kristin, Heier M, Heier, M. (Margit), Meitinger T, Mattias Lorentzon, Harris, TB, Tsung-Sheng Wu, Lorentzon, Mattias,, Kiel, D.P., Coviello AD, Bhasin, S., Lunetta, K.L. (Kathryn), Raitakari, Olli, Mellström, Dan,, Bidlingmaier, M. (Martin), Murabito, J.M., Claes Ohlsson, Perry, J.R.B., Wu, T.S., Vandenput, L, Petersen, AK, Huhtaniemi, I.T. (Ilpo), Nilsson M, Pye, S.R., Petersen Ann-Kristin, Hofman, Albert, Jansson, John-Olov,, Yongmei Liu, Teumer Alexander, André G. Uitterlinden, Vandenput, L. (Liesbeth), Meitinger, Thomas, Douglas P. Kiel, Jong, Frank, Karlsson, M.K. (Magnus), Kathryn L. Lunetta, Voelzke, Henry, Völker Uwe, Wei Vivian Zhuang, Wu FC, Lyytikäinen, L.-P. (Leo-Pekka), Vasan, R.S., Ann-Kristin Petersen, Lehtimäki, T. (Terho), Thomas Meitinger, Kate L Holliday, Karasik, D, Lyytikainen, Leo-Pekka, Holliday KL, Miljkovic Iva, Eriksson, Joel, Lorentzon Mattias, Wallaschofski Henri, Ilpo T. Huhtaniemi, Koster Annemarie, Lorentzon, M., Bidlingmaier, Martin, Stolk, L. (Lisette), Huhtaniemi, Ilpo T, Coviello Andrea D., Osten Ljunggren, Lunetta KL, Huhtaniemi IT, Bidlingmaier, M., Ferrucci, L., Wu, Tsung Sheng, Maggio, M, David Melzer, Vandenput, L., Tajar A, Henry Völzke, Wu TS, Stolk L, Lehtimaki, Terho, Ilpo T Huhtaniemi, Lehtimäki, T, Lorentzon M, H Erich Wichmann, null null, Ziv, E., Vandenput, Liesbeth,, Heier, M., Tajar Abdelouahid, Eriksson, Joel,, Reincke, Martin, Wichmann, H Erich, Penninx, B, Holliday, K.L., Karasik D, Stephen R Pye, Holliday, KL, Teumer, A. (Alexander), Hofman, Bert, Andrea D. Coviello, Völker U, Liu, Y. (YongMei), Lyytikäinen, L.-P., Karlsson, M.K., Mellström Dan, Wallaschofski, H. (Henri), Ferrucci, Luigi, Meitinger, T., Nilsson, M., Coviello, Andrea D, Jorma Viikari, Ljunggren Östen, Hammond Geoffrey L., Heier Margit, Ziv Elad, Rivadeneira Fernando, Haring, R, Lunetta, Kathryn L, Ohlsson, C., Meitinger Thomas, Viikari J, Holliday Kate L., Lorentzon, Mattias, Lorentzon, M. (Mattias), Margit Heier, Miljkovic, I., Bhasin S, O'Neill, Terence, Eriksson, J., Rivadeneira, Fernando, Lyytikäinen, LP, Völker, Uwe, Hammond, Geoffrey L, Bidlingmaier Martin, de Jong Frank H., Haring, Robin, Karlsson MK, Murray, A., Raitakari, O., Harris, T.B., Penninx, Brenda, Kähönen, M. (Mika), Nilsson, M, Karasik, D. (David), Olli Raitakari, Ohlsson, Claes,, Völzke, Henry, Liu, Y.M., Wichmann, HE, H. Erich Wichmann, Coviello, Andrea D., Völker, U, Lunetta, K.L., Viikari, J., Viikari, J. (Jorma), Lyytikäinen Leo-Pekka, Vasan Ramachandran S., Kiel, DP, Martin Bidlingmaier, Ziv, Elad, Murabito, JM, Petersen, A.-K., Raitakari Olli, Teumer, Alexander, Harris, Tamara B., Leo-Pekka Lyytikäinen, Elad Ziv, Pye SR, Lyytikainen, L.P., Ramachandran S. Vasan, Emas Study Group,, Nauck Matthias, Nauck, M, Vasan, RS, Karlsson, Magnus K, Henri Wallaschofski, Melzer D, Uitterlinden, André; id_orcid, Kahonen, Mika, Rivadeneira, F., Liu, Yongmei, Holliday, K.L. (Kate), Holliday, Kate L, Viikari, J, Völzke H, Ulloor, J., Raitakari O, Jagadish Ulloor, Maggio, M., Perry, JRB, Jansson, J.O., Joanne M. Murabito, Pye Stephen R., Hofman, A. (Albert), Lehtimäki T, Bhasin, Shalender, Melzer David, Viikari Jorma, de Jong, F.H., Coviello, A.D. (Andrea), Albert Hofman, Perry John R. B., Geoffrey L Hammond, Ulloor J, Huhtaniemi, Ilpo T., Harris Tamara B., Meitinger, T, Uitterlinden André G., André G Uitterlinden, Maggio, M. (Marcello), Melzer, D. (David), Melzer, D., Maria Nilsson, Reincke, M. (Martin), Ljunggren, Ö., Zhuang, WV, Karasik, D., Viikari, Jorma, Karlsson, MK, Zhuang, W.V., Huhtaniemi, IT, Wu, Frederick CW, Liesbeth Vandenput, Anna Eriksson, Huhtaniemi, I.T., Ziv, E, Uitterlinden, A.G., Karasik, David, Liu Yongmei, Teumer A, Eriksson Joel, Wichmann, Heinz-Erich, Alexander Teumer, Geoffrey L. Hammond, Nauck, M. (Matthias), Magnus K Karlsson, Kiel DP, Vasan, R.S. (Ramachandran Srini), Ohlsson C, Anna Murray, Karlsson, Magnus K., Ulloor, Jagadish, Ferrucci L, Hammond, G.L. (Geoffrey), John R. B. Perry, Koster, A. (Annemarie), Ljunggren, O, Karlsson Magnus K., Ljunggren O, Vasan RS, Shalender Bhasin, Kähönen, Mika (Tay), Bhasin Shalender, Jong, F.H. (Frank) de, de Jong FH, Wichmann, H. Erich, Penninx, B., Wallaschofski H, Raitakari, O. (Olli), Hofman, A, Reincke M, Perry, John R B, Perry, John RB, Pye, S.R. (Stephen), Penninx, B.W.J.H. (Brenda), Wu, Frederick C W, Stolk, L, Andrea D Coviello, Magnus K. Karlsson, Bidlingmaier M, Jansson, John-Olov, Petersen, Ann-Kristin, Zhuang Wei Vivian, Hammond, GL, Bhasin, S. (Shalender), Eriksson, J. (Joel), Meitinger, T. (Thomas), Mellström, D. (Dan), Uwe Völker, Liu, Y., Murabito, Joanne M, Kathryn L Lunetta, de Jong, FH, Wichmann H. Erich, Eriksson, Anna, Ohlsson, Claes, Lisette Stolk, Terho Lehtimäki, Jansson John-Olov, Maggio Marcello, Karasik David, Lehtimäki, T., Kähönen, M., Mellström, D., Völker, U., Völzke, H. +480 morecore +1 more sourceMetabolic and Fluid Biomarkers Support Microglia Activation in Amyotrophic Lateral Sclerosis
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT
Amyotrophic lateral sclerosis is an incurable neurodegenerative disease involving motor neuron degeneration and metabolic and immune dysfunction. We combined clinical data, cerebrospinal fluid biomarkers and fluorodeoxyglucose positron emission tomography with magnetic resonance imaging to investigate the role of reactive microglia in disease ...Matteo Zanovello, Francesca Serani, Alen Bebeti, Federica Paredi, Giulia Quadrio, Andrea Fortuna, Giacomo Maria Minicuci, Elena Pegoraro, Annachiara Cagnin, Diego Cecchin, Gianni Sorarù +10 morewiley +1 more sourceStage‐Specific Patterns of Imaging and Non‐Motor Biomarkers in Spinocerebellar Ataxia Type 3
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective
Advancements in disease‐modifying therapies for spinocerebellar ataxia Type 3 (SCA3) underscore the need for robust biomarkers to monitor disease progression and evaluate treatment efficacy. Although motor phenotypes have been well characterized, less is known about non‐motor and imaging‐based features across different disease stages.Chun Li, Zhi‐Xian Ye, Xuan‐Yu Chen, Liang‐Liang Qiu, Zhi‐li Chen, Yu‐Sen Qiu, Wei Lin, Ru‐Ying Yuan, Xin‐Tong Yu, Chun‐Yu Huang, Xin‐Yuan Chen, Min‐Ting Lin, Jian‐Ping Hu, Wan‐Jin Chen, Ning Wang, Shao‐Bo Yao, Shi‐Rui Gan, Ying Fu +17 morewiley +1 more source
