Results 231 to 240 of about 2,563,144 (300)

Gapless Complete Genome and Multi‐Omics Illuminate Immune Adaptation and Host‐Virus Interactions in a Coronavirus Reservoir

Advanced Science, EarlyView.
We present a complete T2T genome assembly for a key bat reservoir. Integrating population genomics, comparative genomics, transcriptomics, single‐cell omics, and functional assays, we resolve previously inaccessible genomic regions and identify evolutionary signatures associated with immune adaptation.
Yuting Wang, Sheng Zhang, Linxia Ouyang, Xin Du, Xin Huang, Zhilin Wang, Huixian Xie, Jiale Tang, Liyi Lou, Wenqing Ling, Weihao Wang, Jiang Zhou, Zhen Liu, Yibo Hu, Fuwen Wei, Guangping Huang   +15 more
wiley   +1 more source

Molecular Detection of the -308 G/A Polymorphism in the <i>Tumor Necrosis Factor Alpha</i> (<i>TNFα</i>) Gene Promoter and Its Relationship with the Development of Severe Dengue in Patients from Urabá Subregion, Antioquia-Colombia. [PDF]

Microorganisms
Salazar Flórez JE, Sánchez RGP, Cardona LSG, Salas LCA, Garro JMM, Torres-Castro M, Monroy FP, López-Rojas LE, Velasquez KM, Jaramillo BNR, Naranjo MA.   +10 more
europepmc   +1 more source

Human Engineered Heart Tissues Reproduce Trigger‐ and Substrate‐Driven Mechanisms of Ventricular Tachycardia

Advanced Science, EarlyView.
Engineered heart tissues (EHTs) derived from human iPSCs replicate mechanisms of ventricular tachycardia at the tissue level. Acquired Long‐QT conditions cause early afterdepolarizations, wavebreak, and transient rotors; in contrast, focal cryoinjury forms a stable substrate that supports ongoing reentry.
Matthew Fiedler, Alejandra Vasquez Limeta, Ernesto Reyes Sanchez, Leah Carter, Francisco Altamirano   +4 more
wiley   +1 more source

Low genetic polymorphism of the PvMSP1-19 vaccine candidate among Plasmodium vivax isolates along the Thailand-Myanmar border. [PDF]

Parasite
Pitchayatanakorn P, Boonpeng K, Inthanon N, Khamkheaw C, Chanphetr S, Tansuangkunnatham J, Kijprasong K, Srisutham S.   +7 more
europepmc   +1 more source

XChrom: A Cross‐Cell Chromatin Accessibility Prediction Model Integrating Genomic Sequence and Cellular Context

Advanced Science, EarlyView.
XChrom is a deep learning framework that integrates genomic sequence and single‐cell context to predict chromatin accessibility. It generalizes to unseen cells and genomic regions, enabling cross‐sample and cross‐species analysis. Applied to COVID‐19 patient data, XChrom reveals key transcriptional regulatory mechanisms and disease‐associated ...
Yuanyuan Miao, Xuan Liang, Wenwen Zhang, Dongmei Han, Yurun Li, Zhen Wang   +5 more
wiley   +1 more source

Morphometric characterization of indigenous cattle in the Sidama region, Ethiopia, with preliminary screening of hemoglobin polymorphism. [PDF]

Vet Anim Sci
Kumburo GY, Taffese HH, Gebreslase HW, Walelign EM.   +3 more
europepmc   +1 more source

Hydrodynamic Selection of Polymorphic Assembly Pathways in Plant Protein Amyloid Fibrils

Advanced Science, EarlyView.
Hydrodynamic conditions are revealed to govern polymorphic assembly of soy protein amyloid fibrils. Distinct flow‐induced drafting, kissing, and docking dynamics direct fibril growth into multiple morphologies, linking fluid mechanics with nanoscale assembly and enabling rational design of functional amyloid materials.
Zejian Xu, Pengfei Yang, Meng Li, Zichen Cao, Tian Lan, Yan Zhang, Weibiao Zhou, Lianzhou Jiang, Xiaonan Sui   +8 more
wiley   +1 more source

Divergent associations between adiposity and hernia subtypes in European populations: A Mendelian randomization study. [PDF]

Medicine (Baltimore)
Lu Y, Yuan H, Zhang K, Liu D.
europepmc   +1 more source

An Integrated Framework Coupling Hierarchical Hyperspectral i‐trait Screening, Gene Identification, and Functional Validation for Genetic Dissection of Salt Tolerance in Cotton

Advanced Science, EarlyView.
An integrated phenomics–genomics framework captures dynamic salt‐stress responses in laboratory‐grown cotton seedlings through time‐series hyperspectral imaging and non‐destructive i‐trait extraction. Hierarchical screening identifies biologically relevant, heritable, and non‐redundant traits for high‐resolution GWAS, identifying GhST7.
Bowei Xu, Le Liu, Mengli Yu, Yuling Guo, Junli Ye, Jun Zhang, Rumeng Zhao, Jiajie Yang, Wanneng Yang, Yameng Xu, Liqiang Fan, Zuoren Yang   +11 more
wiley   +1 more source

Personalized Prediction of Cutaneous Melanoma Risk Based on Polymorphism of the Genes Related to Skin Aging, Phenotypic Characteristics, and Sun Exposure in Lithuania. [PDF]

Cancers (Basel)
Butrimas G, Šemeklis L, Paukštaitienė R, Ogulevičiūtė A, Mišeikytė G, Lukšienė D, Valiukevičienė S.   +6 more
europepmc   +1 more source