Results 241 to 250 of about 648,932 (289)

Hepatic CBP/p300 Orchestrate Amino Acid‐Driven Gluconeogenesis through Histone Crotonylation

Advanced Science, EarlyView.
Hepatic CBP/p300 control amino acid‐driven gluconeogenesis by modulating histone crotonylation. This study identifies 2‐aminoadipate (2‐AAA) as a key metabolite that enhances crotonylation and activates amino acid and gluconeogenic gene expression.
Chunxiang Sheng, Tianjiao Li, Hong Lin, Xiaoqin Ma, Feiye Zhou, Mingzhu Li, Yiru Wang, Shushu Wang, Jialin Tan, Junmin Chen, Yulin Yang, Jianmin Liu, Yufang Bi, Jieli Lu, Xiao Wang, Libin Zhou   +15 more
wiley   +1 more source

<i>TLR3</i> rs3775291 C/T polymorphism is associated with elevated IFN-α level in asymptomatic HTLV-1 infection. [PDF]

Front Cell Infect Microbiol
Ferreira FDS, Brito WRDS, Santana EGM, Oliveira AKA, de Lima ACR, Amoras EDSG, da Costa CA, Souza MS, Lima SS, Ishak R, Cayres-Vallinoto IMV, Vallinoto ACR, Queiroz MAF.   +12 more
europepmc   +1 more source

Top‐Down Fabricated Wood‐Derived Pressure and Strain Sensors: A Review

Advanced Science, EarlyView.
This review focuses on wood‐derived pressure/strain sensors fabricated via top‐down strategies. It analyzes wood's structural composition, examines processing techniques, discusses sensor types and sensing mechanisms, and reviews existing research. The article concludes with future directions for enhancing performance and scalability.
Yi Ren, Fuyao Liu, Yanan Zhong, Shengbo Ge, Zhipeng Shi, Siling Lin, Hongli Song, Yingying Zhang, Wei Fan   +8 more
wiley   +1 more source

Development of simple sequence repeat markers and genetic diversity of <i>Sipunculus nudus</i> in the Beibu Gulf of China. [PDF]

PeerJ
Han C, Ni Y, Yang G, Yang J, Zou J, Peng H, Wang P.   +6 more
europepmc   +1 more source

Allele‐Specific Regulation of PAXIP1‐AS1 by SMC3/CEBPB at rs112651172 in Psychiatric Disorders Drives Synaptic and Behavioral Dysfunctions in Mice

Advanced Science, EarlyView.
This study identifies a functional noncoding variant, rs112651172 (C/G), that drives allele‐specific expression of PAXIP1‐AS1 in monozygotic twin pairs discordant for schizophrenia and bipolar disorder. The risk G allele enhances CEBPB binding, leading to lncRNA upregulation, CNTNAP3 derepression, and synaptic and behavioral deficits in mice.
Chaoying Ni, He Chen, Qiaqi Chen, Yangyang Liao, Yunqian Wang, Linyan Ye, Xiaohui Wu, Hongyu Ni, Tingyun Jiang, Shufen Li, Qiong Yang, Hong Xue, Zhongju Wang, Feng Yi, Cunyou Zhao   +14 more
wiley   +1 more source

Association of IL-10, IL-6, and TNF-α polymorphisms with acute coronary syndrome risk: a systematic review, meta-analysis, and trial sequential analysis. [PDF]

BMC Med Genomics
Luo Y, Li S, Ding Y, Shi S.
europepmc   +1 more source

Shear Conditioning Promotes Microvascular Endothelial Barrier Resilience in a Human BBB‐on‐a‐Chip Model of Systemic Inflammation Leading to Astrogliosis

Advanced Science, EarlyView.
Physiological flow (0.5 Pa) conditioning promotes resilience of an iPSC‐derived blood–brain barrier endothelium to mild systemic inflammation. In contrast, high “cytokine storm” levels induce barrier breakdown, fibrinogen leakage, and astrocyte activation, reconstituting the two‐hit injury mechanism on‐a‐chip.
Kaihua Chen, Isabelle M. Linares, Michelle A. Trempel, Alexis M. Feidler, Dinindu De Silva, Sami Farajollahi, Jordan Jones, Julia Kuebel, Pelin Kasap, Britta Engelhardt, Jonathan Flax, Vinay V. Abhyankar, Richard E. Waugh, Harris A. Gelbard, Niccolo Terrando, James L. McGrath   +15 more
wiley   +1 more source

Whole-genome resequencing revealed genetic structure and specific breed identification loci of Ningxia Jingyuan chicken breed (Gallus gallus). [PDF]

BMC Genomics
Yue YX, Zhang X, Zhai B, Zhang ZH, Li YJ, Li ZJ, Kang XT, Li H, Wang KJ, Li WT, Liu XJ, Zhang J, Tian YD.   +12 more
europepmc   +1 more source

Achieving Temperature‐Insensitive High Piezoelectricity by Reentrant Relaxor Transition

Advanced Science, EarlyView.
Although precision sensors and actuators demand piezoelectric materials with temperature‐insensitive high piezoelectricity, achieving such a property is challenging. This paper reports that reentrant relaxor transitions can break the trade‐off between high piezoelectricity and temperature insensitivity. High piezoelectricity (350 pC N−1) is achieved in
Yang Yang, Shichang Li, Liqiang He, Guanqi Wang, Chang Liu, Yiqiao Song, Yuanchao Ji, Hanbing Zhang, Jiantuo Zhao, Dong Wang, Xiaobing Ren   +10 more
wiley   +1 more source