Results 241 to 250 of about 3,539,255 (350)

CD103+ T Cells Eliminate Damaged Alveolar Epithelial Type II Cells Under Oxidative Stress to Prevent Lung Tumorigenesis

Advanced Science, Volume 12, Issue 28, July 24, 2025.
This work unravels a novel function of CD103+ T cells in eradicating oxidative‐stressed somatic cells to prevent lung tumorigenesis and identifies specific CD103+ T cell‐decline as a key feature in the aged lung. This comprehensive study highlights the contribution of immuno‐dysregulation to the high incidence of aging‐associated lung cancers ...
Yu Xu, Haorui Luo, Jiahao Wang, Haifeng Liu, Luonan Chen, Hongbin Ji, Zimu Deng, Xiaolong Liu   +7 more
wiley   +1 more source

Polymorphism's MBOAT7 as Risk and MTARC1 as Protection for Liver Fibrosis in MASLD. [PDF]

Int J Mol Sci
Rocha S, Oliveira CP, Stefano JT, Yokogawa RP, Gomes-Gouvea M, Zitelli PMY, Silva-Etto JMK, Martins ED, Pessoa MG, Alcantara FF, Azevedo RS, Rebello Pinho JR.   +11 more
europepmc   +1 more source

USP8‐Governed MDA5 Homeostasis Promotes Innate Immunity and Autoimmunity

Advanced Science, EarlyView.
This study reveals that USP8 stabilizes MDA5 via AKT‐mediated phosphorylation (Ser718), enhancing their interaction and MDA5 deubiquitination. USP8 inactivation degrades MDA5, suppressing type I IFN and cytokine production. Pharmacological inhibition of USP8/AKT alleviates MDA5‐driven autoimmunity, demonstrating the USP8‐MDA5 axis as a therapeutic ...
Qimin Zhang, Shan Huang, Yan He, Weiwei Wang, Chao Tong, Mengru Ma, Manyu Zhao, Lian Yi, Klaus‐Peter Knobeloch, Peijing Zhang   +9 more
wiley   +1 more source

Angiotensin-converting Enzyme Genetic Polymorphism

Arquivos Brasileiros de Cardiologia, 2014
Somsri Wiwanitkit, Viroj Wiwanitkit
doaj   +1 more source

The relationship of genetic signature for cardiometabolic risk with biomarkers of inflammatory and oxidative stress in diabetic patients. [PDF]

BMC Endocr Disord
Abaj F, Aali Y, Najafi F, Koohdani F.
europepmc   +1 more source

Amyloid Forming Human Lysozyme Intermediates are Stabilized by Non‐Native Amide‐π Interactions

Advanced Science, EarlyView.
Mutational variants of human lysozyme cause fatal systemic amyloidosis by depositing kilograms of protein in the viscera of patients. Central to this process is a partially unfolded protein intermediate state that initiates aggregation into amyloid fibrils.
Minkoo Ahn, Julian O. Streit, Christopher A. Waudby, Tomasz Włodarski, Angelo Miguel Figueiredo, John Christodoulou, Janet R. Kumita   +6 more
wiley   +1 more source

LncRNA <i>C5orf64</i> polymorphisms (rs12518552 and rs2950218) decreases pulmonary tuberculosis susceptibility. [PDF]

Ann Med
Xu S, Hu B, Zhang D, Wang J, He X, He Y, Wang Y.   +6 more
europepmc   +1 more source

review marcatori genetici acquacoltura [PDF]

, 2012
Guarniero, Ilaria
core  

FemXpress: Systematic Analysis of X Chromosome Inactivation Heterogeneity in Female Single‐Cell RNA‐Seq Samples

Advanced Science, EarlyView.
FemXpress is a computational tool that leverages X‐linked single nucleotide polymorphisms (SNPs) to group cells by the origin of the inactivated X chromosome in female single‐cell RNA sequencing (scRNA‐Seq) data. It demonstrates strong performance on both simulated and real datasets without requiring parental genomic information, and can also identify ...
Xin Wang, Yingke Ma, Fan Li, Wentao Cui, Tianshi Pan, Siqi Wang, Sinan Ma, Qingtong Shan, Chao Liu, Yukai Wang, Ying Zhang, Yuanchun Zhou, Wei Li, Pengfei Wang, Qi Zhou, Guihai Feng   +15 more
wiley   +1 more source

Polymorphism of <i>splicing factor 3A subunit 3/PstI</i> gene and its association with the performance of Madura cows (<i>Bos indicus</i>). [PDF]

Vet World
Putra WPB, Hartati H, Margawati ET, Mariyono M, Maulana T, Tyasi TL.   +5 more
europepmc   +1 more source