Results 61 to 70 of about 2,442,442 (301)

Genetic Normalization of Differentiating Aneuploid Human Embryos [PDF]

, 2011
Early embryogenesis involves a series of dynamic processes, many of which are currently not well described or understood. Aneuploidy and aneuploid mosaicism, a mixture of aneuploid and euploid cells within one embryo, in early embryonic development are ...
Paul Brezina, Raymond Anchan, Kevin Richter, Ric Ross, Andrew Benner, William Kearns, Andrew Barker, Khanh-Ha Nguyen, Garry Cutting   +8 more
core  

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

The genetic content of chromosomal inversions across a wide latitudinal gradient [PDF]

, 2012
There is increasing evidence regarding the role of chromosomal inversions in relevant biological processes such as local adaptation and speciation. A classic example of the adaptive role of chromosomal polymorphisms is given by the clines of inversion ...
Simões, Pedro, Calabria Garcia, Gemma, Marta Pascual (88566), Balanyà Joan, Picão Osório, J., Balanyà i Maymó, Joan, Simões Pedro, João Picão-Osório, Pedro Simões (88565), Pascual Berniola, Marta, Gemma Calabria, Marta Pascual, Gemma Calabria (109704), Pascual Marta, João Picão-Osório (109707), Pedro Simões, Calabria Gemma, Picão-Osório João, Joan Balanyà, Joan Balanyà (109709)   +19 more
core   +2 more sources

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Leishmania major: genetic heterogeneity of Iranian isolates by single-strand conformation polymorphism and sequence analysis of ribosomal DNA internal transcribed spacer.

, 2006
Protozoan parasites of Leishmania major are the causative agents of cutaneous leishmaniasis in different parts of Iran. We applied PCR-based methods to analyze L.
Mauricio, Isabel L, Al-Jawabreh, Amer, Alimohammadian, Mohammad Hossein, Tashakori, Mahnaz, Kuhls, Katrin, Farajnia, Safar, Schönian, Gabriele   +6 more
core   +1 more source

Impulsive traits and 5-HT2A receptor promoter polymorphism in alcohol dependents: Possible association but no influence of personality disorders [PDF]

, 2001
Objective: Impulsive behavior in alcoholics puts them at serious risk of severer course of disease and has been related to the serotonergic neurotransmission dysfunction.
Bondy, Brigitta, Preuss, Ulrich W., Soyka, Michael, Bahlmann, Miriam, Koller, G.   +4 more
core   +1 more source

Polymorphism of peripheral blood T cell receptor β chain variable region in patients with clinically isolated syndrome

Chinese Journal of Contemporary Neurology and Neurosurgery, 2020
Objective To investigate the polymorphism of T cell receptor β chain variable region (TCRVβ) in peripheral blood of clinically isoiated syndrome (CIS) patients. To preliminarily predict the specific TCRVβ fragment of CIS and its diagnostic value for CIS.
Yan WU, Ji⁃hong ZHANG, Hui⁃qing DONG, Da⁃wei LI, Zheng LIU, Sui⁃gui WAN   +5 more
doaj  

Polimorfismo genético de la apolipoproteína E en un grupo de escolares del centro-oriente colombiano: comparación con las concentraciones plasmáticas de lípidos y apolipoproteínas

Biomédica: revista del Instituto Nacional de Salud, 2007
Introducción. Estudios mundiales han demostrado la contribución de los alelos de la apolipoproteína E en las variaciones de los lípidos y las apolipoproteínas. Objetivo.
Ney Callas, Elpidia Poveda, César Baracaldo, Patricia Hernández, Carlina Castillo, Martha Guerra   +5 more
doaj   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Genetic variability among Beauveria brongniartii (Saccardo) Petch isolates fromvarious geographical and host origins based on AFLP analysis [PDF]

, 2008
The entomopathogenic hyphomycete Beauveria brongniartii is a promising candidate for biocontrol of economically important agricultural and forest pests.
Reineke, Annette, Zebitz, Claus Paul Walter, Hadapad, Ashok   +2 more
core