Results 51 to 60 of about 420,815 (305)

Cholesterol Ester Transfer Protein Taq1B Polymorphism and Its Association with Cardiovascular Risk Factors in Patients Undergoing Angiography in Yazd, Eastern Iran: A Cross-Sectional Study [PDF]

Iranian Journal of Medical Sciences
Background: Several studies assessed the relationship between the cholesterol ester transfer protein (CETP) Taq1B gene polymorphism (rs708272) with risk factors of cardiovascular diseases (CVDs). However, their findings were inconsistent.
Azam Ahmadi-Vasmehjani, Seyed Mostafa SeyedHosseini, Sayyed Saeid Khayyatzadeh, Farzan Madadizadeh, Mahta Mazaheri-Naeini, Mahdie Yavari, Zahra Darabi, Sara Beigrezaei, Marzieh Taftian, Vahid Arabi, Maryam Motallaei, Amin Salehi-Abargouei, Azadeh Nadjarzadeh   +12 more
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Genetic polymorphism of blood proteins in a population of shetland ponies [PDF]

, 1976
Genetic variation of proteins (protein polymorphism) is widespread among many animal species. The biological significance of protein polymorphism has been the subject of many studies.
Buis, R.C.
core  

The genetic content of chromosomal inversions across a wide latitudinal gradient [PDF]

, 2012
There is increasing evidence regarding the role of chromosomal inversions in relevant biological processes such as local adaptation and speciation. A classic example of the adaptive role of chromosomal polymorphisms is given by the clines of inversion ...
Simões, Pedro, Calabria Garcia, Gemma, Marta Pascual (88566), Balanyà Joan, Picão Osório, J., Balanyà i Maymó, Joan, Simões Pedro, João Picão-Osório, Pedro Simões (88565), Pascual Berniola, Marta, Gemma Calabria, Marta Pascual, Gemma Calabria (109704), Pascual Marta, João Picão-Osório (109707), Pedro Simões, Calabria Gemma, Picão-Osório João, Joan Balanyà, Joan Balanyà (109709)   +19 more
core   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

The rs1990760 polymorphism within the IFIH 1 locus is not associated with Graves' disease, Hashimoto's thyroiditis and Addison's disease [PDF]

, 2009
Background: Three genes have been confirmed as major joint susceptibility genes for endocrine autoimmune disease:human leukocyte antigen class II, cytotoxic T-lymphocyte antigen 4 and protein tyrosine phosphatase non-receptor type 22.
Reisch, Nicole, Badenhoop Klaus, Elizabeth Ramos Lopez, Stefanie Hahner, H. Willemberg, Segni, Maria, Kahles Heinrich, Inka Robbers, Ramos-Lopez, Elizabeth, Hahner, Stefanie, Heinrich Kahles, Willenberg, Holger, Robbers Inka, Seidl, Christian, Marissa Penna Martinez, Christian Seidl, Willenberg, Holger S., Reisch Nicole, Kahles, Heinrich, Penna-Martinez Marissa, Klaus Badenhoop, Penna Martinez, Marissa, Seidl Christian, Badenhoop, Klaus, Robbers, Inka, Penna-Martinez, Marissa, Ramos-Lopez Elizabeth, Hahner Stefanie, Segni Maria, Willenberg Holger, Nicole Reisch   +30 more
core   +1 more source

The c.-1639g>A polymorphism of the VKORC1 gene and his influence on the therapeutic response during oral anticoagulants use [PDF]

Vojnosanitetski Pregled, 2009
Background/Aim. A single nucleotide polymorphism c.- 1639G>A in the promoter region of vitamin K-epoxide reductase (VKORC1) gene has been found to account for most of the variability in response to oral anticoagulants (OA). The aim of the study was to
Kovač Mirjana, Rakićević Ljiljana, Maslać Aleksandar, Radojković Dragica   +3 more
doaj   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Evidencia de asociación entre el gen SLC6A4 y efectos epistáticos con variantes en HTR2A en la etiología del autismo en la población antioqueña

Biomédica: revista del Instituto Nacional de Salud, 2012
Introducción. El espectro autista constituye un grupo de trastornos graves del neurodesarrollo, conun fuerte componente genético. Se ha sugerido un papel importante del sistema serotoninérgico en el desarrollo de este grupo de trastornos, con base en los
Ana Victoria Valencia, Ana Lucía Páez, María Elena Sampedro, Clara Ávila, Julio Cesar Cardona, Catalina Mesa, Lina Galvis, Jaime Carrizosa, Mauricio Camargo, Andrés Ruíz, William Cornejo, Gabriel Bedoya   +11 more
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source