Results 51 to 60 of about 3,328,553 (209)

Polimorfismos de la región promotora del gen de la IL-10 y artritis reumatoide en una población colombiana

Biomédica: revista del Instituto Nacional de Salud, 2007
Introducción. La artritis reumatoide es una enfermedad inflamatoria con un predominio de la actividad de las células TH1 CD4+. La interleucina-10, presente en altas concentraciones en suero y líquido sinovial de pacientes con artritis reumatoide, tiene ...
Olga María Moreno, Clara Isabel González, Diego Luis Saaibi, William Otero, Reynaldo Badillo, Javier Martín, Gerardo Ramírez   +6 more
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Niveles de homocisteína y polimorfismos de los genes de la MTHFR y la CBS en pacientes colombianos con trombosis venosa superficial y profunda

Biomédica: revista del Instituto Nacional de Salud, 2010
Introducción. Se produce trombosis cuando en el sistema hemostático se desequilibran los mecanismos procoagulantes, anticoagulantes y fibrinolíticos, y se forman coágulos dentro de los vasos sanguíneos.
Claudia Ayala, Reggie García, Edith Cruz, Karol Prieto, Marta Bermúdez   +4 more
doaj   +1 more source

Genomic SEM Provides Insights into the Multivariate Genetic Architecture of Complex Traits

Nature Human Behaviour, 2018
Genetic correlations estimated from genome-wide association studies (GWASs) reveal pervasive pleiotropy across a wide variety of phenotypes. We introduce genomic structural equation modelling (genomic SEM): a multivariate method for analysing the joint ...
A. Grotzinger, M. Rhemtulla, R. Vlaming, R. Vlaming, Stuart J. Ritchie, T. Mallard, W. Hill, Hill F. Ip, R. Marioni, A. McIntosh, I. Deary, P. Koellinger, P. Koellinger, K. Harden, M. Nivard, E. Tucker-Drob   +15 more
semanticscholar   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

O polimorfismo AGT*M235T na disfunção cardíaca de etiologia isquêmica aguda: projeto gisca AGT*M235T polymorphism in acute ischemic cardiac dysfunction: the gisca project

Arquivos Brasileiros de Cardiologia, 2010
FUNDAMENTO: O polimorfismo AGT*M235T tem sido associado a elevados níveis séricos de angiotensinogênio (AGT), hipertensão arterial sistêmica e disfunção cardíaca (DC). OBJETIVO: Testar a hipótese de haver associação entre polimorfismo AGT*M235T e o risco
Claudia Guerra Murad Saud, Amália Faria dos Reis, Arlisa Monteiro de Castro Dias, Rosemery Nunes Cardoso, Ana Cristina Klem Vargas Carneiro, Leandro Pereira de Souza, Ana Beatriz Monteiro Fonseca, Georgina Severo Ribeiro, Carlos Augusto Cardozo de Faria   +8 more
doaj  

Association of GPX1 Pro198Leu and SOD1 A251G polymorphisms with risk of acute kidney rejection [PDF]

Scripta Medica
Background/Aim: Acute rejection is one factor threatening the success of kidney transplantation. One of the factors that can cause graft rejection is oxidative stress.
Rayatpisheh Shima, Karimi Mohammad-Hossein, Saadat Iraj   +2 more
doaj   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Polimorfismos beta1-adrenérgico associados com Fibrilação Atrial na Insuficiência Cardíaca Sistólica Beta1-adrenergic receptor polymorphisms associated with atrial fibrillation in systolic heart failure

Arquivos Brasileiros de Cardiologia, 2012
FUNDAMENTO: O sistema nervoso simpático apresenta grande importância na patogênese da fibrilação atrial na insuficiência cardíaca sistólica. A identificação de polimorfismos no gene ADBR1 do receptor beta1-adrenérgico representa um importante passo no ...
Bruno Costa do Nascimento, Sabrina Bernardez Pereira, Georgina Severo Ribeiro, Evandro Tinoco Mesquita   +3 more
doaj  

Inverse correlation of population similarity and introduction date for invasive ascidians. [PDF]

PLoS ONE, 2008
The genomes of many marine invertebrates, including the purple sea urchin and the solitary ascidians Ciona intestinalis and Ciona savignyi, show exceptionally high levels of heterozygosity, implying that these populations are highly polymorphic. Analysis
Nathan Silva, William C Smith
doaj   +1 more source