Results 181 to 190 of about 444,739 (309)

Defective Ribosome Recycling: A Bridge Between Translation Fidelity, Organelle Dysfunction, and Diseases

BioEssays, EarlyView.
The Role of Ribosome Recycling in Human Diseases This diagram highlights how disruptions in ribosome translation and recycling can negatively impact cellular and organismal health. Usually, these processes operate efficiently to maintain cellular protein homeostasis.
Foozhan Tahmasebinia, Zhihao Wu
wiley   +1 more source

Causal relationship between statins and hemorrhagic stroke: A drug-target Mendelian randomization analysis. [PDF]

Medicine (Baltimore)
Xia M, Huang N.
europepmc   +1 more source

Generation of Clonal Cultures of Adherent or Suspension Cells Using Flat Sessile Drops for Assurance of Monoclonality

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Single‐cell isolation is an essential step in many biomedical workflows, including genetic analyses and drug‐based assays. It is commonly attempted through limiting dilution into microtiter wells. However, dark optical edge effects at the well periphery make it difficult to confirm which wells contain just one cell.
Joseph A. E. Morgan, Peter R. Cook, Alfonso A. Castrejón‐Pita, Edmond J. Walsh   +3 more
wiley   +1 more source

Role of Immune Cells in Mediating the Effect of Hypothyroidism on Idiopathic Pulmonary Fibrosis. [PDF]

Clin Respir J
Liu Z, Kou C, Chen X, Yang J, Zhu H, Jiao Y, Zhang D, Zhang W, Li L.   +8 more
europepmc   +1 more source

Endogenous Retrovirus‐Like Particle‐Deficient CHO Cells Can be Generated by CRISPR or shRNA and Enriched Based on Cell‐Surface Expression of Retroviral Envelope Protein

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Despite evidence that they are not functional or infective, retrovirus‐like particles (RVLPs), originating from endogenous proviral sequences in Chinese hamster ovary (CHO) cells, present a safety risk for biotherapeutics manufactured using this cell line due to their resemblance to other mammalian leukemia viruses.
Matthew Stuible, Sergio P. Alpuche‐Lazcano, Christian Gervais, Manon Ouimet, Julie Lippens, Martine Pagé, Audrey Morasse, Anna N. Moraitis, Yves Durocher   +8 more
wiley   +1 more source

Impact of Pharmacogenetics on Pharmacokinetics of First-Line Antituberculosis Drugs in the HIRIF Trial. [PDF]

J Infect Dis
Mackay E, Platt G, Peloquin CA, Brooks MB, Coit JM, Velásquez GE, Pertinez H, Vargas D, Sánchez E, Calderón RI, Jiménez J, Tintaya K, Garcia D, Osso E, Lecca L, Mitnick C, Davies GR.   +16 more
europepmc   +1 more source

ABCC11 Earwax Trait and Genotype Are Suitable Tools for Introductory Labs to Learn Genetics and Molecular Techniques

Biochemistry and Molecular Biology Education, EarlyView.
ABSTRACT Professional experiments in genetic research usually start in a class at university. However, interest in genetic research techniques from an early age is essential. We have continuously performed a short genetic experimental course for high school students using a simple molecular experiment and computer‐based learning for Mendelian ...
Tohru Ohta, Rie Takai, Akiko Yoshida, Durga Paudel, Sarita Giri, Takao Kitagawa, Toshiya Arakawa, Yasuhiro Kuramitsu, Tomoharu Tokutomi   +8 more
wiley   +1 more source

The causal relationship between chronic obstructive pulmonary disease and Barrett's esophagitis: A two-sample Mendelian randomization study. [PDF]

Medicine (Baltimore)
Yi N, Huang J, Deng Z, Liang Y.
europepmc   +1 more source

Causal associations between schizophrenia and other psychiatric disorders: A Mendelian randomization study. [PDF]

J Int Med Res
Zhou Y, Chen Y, Wang P, Zhang K, Zhang Y.   +4 more
europepmc   +1 more source

Short‐chain acyl post‐translational modifications in cancers: Mechanisms, roles, and therapeutic implications

Cancer Communications, EarlyView.
Abstract Post‐translational modifications (PTMs) play a pivotal role in epigenetic regulation and are key pathways for modulating protein functionality. PTMs involve the covalent attachment of distinct chemical groups, such as succinyl, crotonyl, and lactyl, at specific protein sites, which alter protein structure, function, stability, and activity ...
Ting Wu, Yingqi Zhao, Xin Zhang, Yuanhe Wang, Qiuchen Chen, Mingrong Zhang, Huan Sheng, Yuying Zhang, Jinyu Guo, Jun Li, Yuxuan Fan, Ziqing Wang, Yalun Li, Haoran Wang, Minjie Wei, Xiaoyun Hu, Huizhe Wu   +16 more
wiley   +1 more source