British Journal of Clinical Pharmacology, EarlyView.While the event‐free survival (EFS) of children treated for acute lymphoblastic leukaemia (ALL) has improved greatly in the last decades, the EFS for patients diagnosed with ALL before the age of one is still under 50%. This outcome further decreases when infants have a rearrangement in the gene encoding histone‐lysine N‐methyltransferase 2A (KMT2A ...
Tirsa de Kluis +5 more
wiley +1 more source
Effects of genotype × environment interactions on the morphological and genetic aspects of the seed characteristics of faba beans. [PDF]
Plant GenomeSallam A +4 more
europepmc +1 more source
Zebrafish: A Versatile and Powerful Model for Biomedical Research
BioEssays, EarlyView.Zebrafish are vital for advancing precision medicine, offering a genetically tractable and optically transparent vertebrate model with strong genetic homology to humans. They enable rapid and cost‐effective disease modeling and drug discovery, accelerating insights into cardiovascular, neurological, metabolic, and oncological disorders through gene ...
Sundus Siddiqui +3 more
wiley +1 more source
Effect of Visceral Adipose Tissue on Major Depressive Disorder: A Mendelian Randomisation Research. [PDF]
Actas Esp PsiquiatrLi X, Zhou X, Li Y, Lei C.
europepmc +1 more source
Biochemistry and Molecular Biology Education, EarlyView.ABSTRACT Professional experiments in genetic research usually start in a class at university. However, interest in genetic research techniques from an early age is essential. We have continuously performed a short genetic experimental course for high school students using a simple molecular experiment and computer‐based learning for Mendelian ...
Tohru Ohta +8 more
wiley +1 more source
Common but Least Noticed: Diversity of the Mangrove Fern Acrostichum aureum in Hainan Island, China
Biological Diversity, EarlyView.Acrostichum aureum across nine coastal sites in Hainan Island was examined using morphological, cytometric, and genomic approaches. Three priority conservation areas are proposed to preserve extant genetic diversity and maintain habitat connectivity. ABSTRACT Acrostichum aureum across nine coastal sites in Hainan Island was examined using morphological,
Bingyan Guo +9 more
wiley +1 more source
Association of Single Nucleotide Polymorphisms in the Cyclooxygenase-2 (COX-2) Gene with Periodontal Disease-A Systematic Review with Meta-Analysis and Implications for Personalized Dentistry. [PDF]
J Pers MedSavva V, Fragkioudakis I, Sakellari D.
europepmc +1 more source
Breaking barriers: the cGAS‐STING pathway as a novel frontier in cancer immunotherapy
Cancer Communications, EarlyView.Abstract Since its discovery, the cyclic GMP‐AMP synthase (cGAS)‐stimulator of the interferon gene (STING) signaling pathway has been considered a pivotal component of innate immunity and a promising target for cancer immunotherapy. Beyond its canonical role in pathogen defense, accumulating evidence has demonstrated that the cGAS‐STING pathway ...
Yuheng Yan +5 more
wiley +1 more source
Causal relationship between interleukin-6 levels and the risk of synovitis and tenosynovitis: A two-sample Mendelian randomization study. [PDF]
Medicine (Baltimore)Wang B +5 more
europepmc +1 more source
Model‐Based Optimization of Fed‐Batch In Vitro Transcription
ChemBioChem, EarlyView.Using a mathematical model for the enzyme kinetics and solution thermodynamics of the in vitro transcription reaction, new optimized strategies are developed for fed‐batch transcription that can decrease the resource costs of mRNA synthesis while maintaining critical quality attributes for efficacy in vivo.
Nathan Merica Stover +5 more
wiley +1 more source