Results 71 to 80 of about 900,745 (376)

Correlation between MDM2 T309G single nucleotide polymorphism and esophageal cancer susceptibility: An updated meta‐analysis

Thoracic Cancer, 2020
Background The aim of this study was to investigate the correlation between MDM2 T309G single nucleotide polymorphism (SNP) and esophageal cancer susceptibility through pooling the open published data.
Lele Yin, Guo Shen, Bin Zhu
doaj   +1 more source

Hidden Markov models for the assessment of chromosomal alterations using high-throughput SNP arrays [PDF]

Annals of Applied Statistics 2008, Vol. 2, No. 2, 687-713, 2008
Chromosomal DNA is characterized by variation between individuals at the level of entire chromosomes (e.g., aneuploidy in which the chromosome copy number is altered), segmental changes (including insertions, deletions, inversions, and translocations), and changes to small genomic regions (including single nucleotide polymorphisms).
arxiv   +1 more source

Estimation of pleiotropy between complex diseases using single-nucleotide polymorphism-derived genomic relationships and restricted maximum likelihood

Bioinform., 2012
SUMMARY Genetic correlations are the genome-wide aggregate effects of causal variants affecting multiple traits. Traditionally, genetic correlations between complex traits are estimated from pedigree studies, but such estimates can be confounded by ...
S. Lee, Jian Yang, M. Goddard, P. Visscher, N. Wray   +4 more
semanticscholar   +1 more source

Single Nucleotide Polymorphism Promoter -765g/C Gen Cox-2 sebagai Faktor Risiko Terjadinya Karsinoma Kolorektal [PDF]

, 2017
Karsinoma kolorektal (KKR) merupakan keganasan yang berasal dari transformasi neoplastik sel-sel epitel kolon dan rektum, menempati urutan ketiga terbanyak dari seluruh kanker di seluruh dunia.Berbagai Perubahan DNA dapat terjadi akibat paparan dengan ...
Saleh, I. (Irsan), Triwani, T. (Triwani)
core  

Inter-individual variation in nucleotide excision repair in young adults: effects of age, adiposity, micronutrient supplementation and genotype [PDF]

, 2009
Nucleotide excision repair (NER) is responsible for repairing bulky helix-distorting DNA lesions and is essential for the maintenance of genomic integrity.
Alison Spiers, Ann K. Daly, Brian Burtle, Elizabeth A. Williams, Fiona Caple, Gaivão, John C. Mathers, John E. Hesketh, John Tyson, Qiao, Tomasetti, Wei   +11 more
core   +1 more source

MET and NF2 alterations confer primary and early resistance to first‐line alectinib treatment in ALK‐positive non‐small‐cell lung cancer

Molecular Oncology, EarlyView.
Alectinib resistance in ALK+ NSCLC depends on treatment sequence and EML4‐ALK variants. Variant 1 exhibited off‐target resistance after first‐line treatment, while variant 3 and later lines favored on‐target mutations. Early resistance involved off‐target alterations, like MET and NF2, while on‐target mutations emerged with prolonged therapy.
Jie Hu, Ning Ding, Xiaobo Xu, Yedan Chen, Yong Zhang, Jingwen Liu, Jiebai Zhou, Hairong Bao, Donghui Zhang, Yijun Song, Yang Shao, Yuanlin Song   +11 more
wiley   +1 more source

Possible role of human ribonuclease dicer in the regulation of R loops

FEBS Open Bio, EarlyView.
R loops play an important role in regulating key cellular processes such as replication, transcription, centromere stabilization, or control of telomere length. However, the unscheduled accumulation of R loops can cause many diseases, including cancer, and neurodegenerative or inflammatory disorders. Interestingly, accumulating data indicate a possible
Klaudia Wojcik, Paulina Krzeminska, Anna Kurzynska‐Kokorniak   +2 more
wiley   +1 more source

Comparative study of adenosine 3′‐pyrophosphokinase domains of MuF polymorphic toxins

FEBS Open Bio, EarlyView.
With the ultimate goal of understanding the association of toxin‐immunity modules to temperate phages, we characterized toxins from three prophages and examined cross‐protection from immunity proteins. The toxins exhibit adenosine 3′‐pyrophosphokinase activity and are toxic in Escherichia coli.
Eloïse M. Paulet, Julia Bartoli, Atakan Kabtan, Chloé M. Piras, Audrey C. Tempier, Eric Cascales, Julie P. Viala   +6 more
wiley   +1 more source

InDelGT: An integrated pipeline for extracting indel genotypes for genetic mapping in a hybrid population using next‐generation sequencing data

Applications in Plant Sciences, Volume 10, Issue 6, November-December 2022., 2022
Abstract Premise Although several software packages are available for genotyping insertion/deletion (indel) polymorphisms in genomes using next‐generation sequencing data, simultaneously calling indel genotypes across many individuals for use in genetic mapping remains challenging. Methods and Results We present an integrated pipeline, InDelGT, for the
Zhiliang Pan, Jinpeng Zhang, Shengjun Bai, Zhiting Li, Chunfa Tong   +4 more
wiley   +1 more source

Genetic population structure of the critically endangered stellate sturgeon (Acipenser stellatus) in the Black Sea basin: Implications for conservation

Aquatic Conservation: Marine and Freshwater Ecosystems, Volume 32, Issue 12, Page 1926-1939, December 2022., 2022
Abstract Stellate sturgeon (Acipenser stellatus) is a species of great conservation concern throughout its range. Over the past century, it has experienced a dramatic decline in abundance and distribution in the Black Sea basin. Information regarding the genetic structure of the species is very limited in the region, despite its crucial importance for ...
Daniela Nicoleta Holostenco, Mitică Ciorpac, Șirin Firidin, Oguzhan Eroglu, Devrim Memiș, Marian Paraschiv, Ștefan Honț, Marian Iani, Katarina Tošić, Elena Taflan, Daniela Porea, Petra Kersten, İlhan Aydın, Radu Suciu, Jörn Gessner, Geta Rîșnoveanu, Klaus Kohlmann   +16 more
wiley   +1 more source