Results 51 to 60 of about 306,247 (295)

Clinical Impact of Single Nucleotide Polymorphism in CD-19 on Treatment Outcome in FMC63-CAR-T Cell Therapy. [PDF]

, 2023
Chimeric antigen receptor (CAR)-T cell therapy is effective in patients with relapsed or refractory diffuse large B-cell lymphoma (r/r DLBCL) with response rates of 63-84% and complete response observed in 43-54%.
Mariesol Abbühl, Daskalakis, Michael, Pabst, Thomas, Bacher, Vera, Nilius, Henning, Katja Seipel, Henning Nilius, Thomas Pabst, Seipel, Katja, Abbühl, Mariesol, Ulrike Bacher, Michael Daskalakis   +11 more
core   +1 more source

Software complex for simulation modelling of single nucleotide genetic polymorphism sites

Informatika
Objectives. High-throughput sequencing methods have recently become widely used in the fundamental and applied research of various human diseases. Sequencing of functionally significant regions of the human genome enables the simultaneous identification ...
M. M. Yatskou, D. D. Sarnatski, V. V. Skakun, V. V. Grinev   +3 more
doaj   +1 more source

Simulasi Metode Statistik untuk Seleksi Single Nucleotide Polymorphism

Biotropika: Journal of Tropical Biology, 2019
Kemajuan teknologi sekuensing menyebabkan peningkatan ketersediaan sekuen genom organisme. Ribuan strain dan isolat dari berbagai populasi organisme telah diisolasi serta diketahui sekuen genomnya.
Mohamad Ikhsan Nurulloh, Hidayat Trimarsanto, Yustinus Ulung Anggraito, Endah Peniati, R Susanti   +4 more
doaj   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

DNAzyme based gap-LCR detection of single-nucleotide polymorphism [PDF]

, 2013
Fast and accurate detection of single-nucleotide polymorphism (SNP) is thought more and more important for understanding of human physiology and elucidating the molecular based diseases.
Du, F, Zhao, YY, Yameen, A, Chen, HD, Zhou, L, Tang, Z   +5 more
core  

The promoter polymorphism -232C/G of the PCK1 gene is associated with type 2 diabetes in a UK-resident South Asian population [PDF]

, 2009
Background: The PCK1 gene, encoding cytosolic phosphoenolpyruvate carboxykinase (PEPCK-C), has previously been implicated as a candidate gene for type 2 diabetes (T2D) susceptibility.
Britten, Abigail C, Barnett Anthony H, Barnett, Anthony, Britten, Abigail C., Bellary, S, Barnett, Anthony H., Anthony H Barnett, Kumar Sudhesh, Rees, Simon D, Britten, Abigail, Sudhesh Kumar, O'Hare, J Paul, Kelly, M Ann, Rees, Simon D., Rees, Simon, Kelly, M. Ann, Kelly, Marilyn, Britten Abigail C, Kelly M Ann, Bellary, Srikanth, Rees Simon D, Srikanth Bellary, Abigail C Britten, J Paul O'Hare, Bellary Srikanth, O'Hare, JP, Kumar, Sudhesh, Barnett, Anthony H, Simon D Rees, Barnett, A. H., O'Hare J Paul, Kumar, S, O'Hare, J. Paul, M Ann Kelly   +33 more
core   +1 more source

Rapid single nucleotide polymorphism mapping in C. elegans

BMC Genomics, 2005
Background In C. elegans, single nucleotide polymorphisms (SNPs) can function as silent genetic markers, with applications ranging from classical two- and three-factor mapping to measuring recombination across whole chromosomes. Results Here, we describe
Hullett Patrick, Harrach Tracey, Hammarlund Marc, Davis M Wayne, Olsen Shawn, Jorgensen Erik M   +5 more
doaj   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Interactions between single nucleotide polymorphism of SERPINA1 gene and smoking in association with COPD: a case–control study [PDF]

, 2017
Xiaowei Deng,1 Cun-hua Yuan,1 De Chang2 1Health Medical Center, 2Department of Respiratory Medicine, General Hospital of Chinese People’s Armed Police Forces, Beijing, People’s Republic of China Background: SERPINA1 gene has been implicated
Yuan CH, Chang D, Deng XW
core  

BovineLD single-nucleotide polymorphism (SNP) gap distribution. [PDF]

, 2012
BovineLD single-nucleotide polymorphism (SNP) gap distribution.
Hoyoung Chung (175120), Curtis P. Van Tassell (175167), Ben J. Hayes (175151), Romain Dassonneville (175125), Xavier David (175133), Cynthia T. Lawley (171073), Tad S. Sonstegard (175161), Karine A. Viaud-Martinez (175180), Paul M. VanRaden (175174), Sébastien Fritz (175137), George R. Wiggans (175183), André Eggen (47250), Didier Boichard (121003), Kimberly J. Gietzen (175145)   +13 more
core   +1 more source