Results 81 to 90 of about 454,115 (308)

Interferon-induced protein with tetratricopeptide repeats 1 (IFIT1) polymorphism as a genetic marker of cerebral malaria in Thai population

Asian Pacific Journal of Tropical Medicine, 2018
Objective: To know whether the effect of interferon-induced protein with tetratricopeptide repeats (IFIT) 1 polymorphism influences the susceptibility of cerebral malaria outcome.
Saw Thu Wah, Hathairad Hananantachai, Jintana Patarapotikul, Jun Ohashi, Izumi Naka, Pornlada Nuchnoi   +5 more
doaj   +1 more source

Single nucleotide polymorphisms of the fukutin gene [PDF]

Journal of Human Genetics, 2001
Mutations in the LMNA gene, which encodes nuclear lamins A and C, underlie both Emery-Dreifuss muscular dystrophy (EMD2) and Dunnigan-type familial partial lipodystrophy (FPLD). This indicates that one gene can cause different phenotypes characterized by tissue degeneration. The gene for one form of Berardinelli-Seip-type congenital total lipodystrophy
Henian Cao, Robert A. Hegele, Jasper Yuen   +2 more
openaire   +3 more sources

A Peptide Nucleic Acid‐Functionalized Heterojunction Thin Film Transistor as a Scalable and Reusable Platform for Label‐Free Detection of MicroRNA

Advanced Functional Materials, EarlyView.
A miniaturized, label‐free, and enzyme‐free biosensor (miR‐TFT) enables direct electrical detection of microRNA (miRNA) with single‐nucleotide specificity and a detection limit of 0.6 fM. Built on a tri‐channel In2O3/ZnO heterojunction and functionalized with bespoke peptide nucleic acid (PNA) probes, the device is robust, reusable, and compatible with
Wejdan S. Al Ghamdi, Jorge Romero Domínguez, Erol Hasan, Temur Maksudov, Thomas D. Anthopoulos, Dana Alsulaiman   +5 more
wiley   +1 more source

dbSNP: a database of single nucleotide polymorphisms [PDF]

Nucleic Acids Research, 2000
In response to a need for a general catalog of genome variation to address the large-scale sampling designs required by association studies, gene mapping and evolutionary biology, the National Cancer for Biotechnology Information (NCBI) has established the dbSNP database. Submissions to dbSNP will be integrated with other sources of information at NCBI
Minghong Ward, Elizabeth M. Smigielski, Karl Sirotkin, Stephen T. Sherry   +3 more
openaire   +3 more sources

The Drosophila genome nexus: a population genomic resource of 623 Drosophila melanogaster genomes, including 197 from a single ancestral range population. [PDF]

, 2015
Hundreds of wild-derived Drosophila melanogaster genomes have been published, but rigorous comparisons across data sets are precluded by differences in alignment methodology.
Cardeno, Charis M, Corbett-Detig, Russell B, Crepeau, Marc W, Lack, Justin B, Langley, Charles H, Pool, John E, Stevens, Kristian A, Taylor, William   +7 more
core   +1 more source

A Novel Brain Penetrable Nanocarrier Delivers Brain‐Derived Neurotrophic Factor to Treat Alzheimer's Disease

Advanced Healthcare Materials, EarlyView.
A novel blood‐brain barrier‐penetrating terpolymer nanoparticle to deliver brain‐derived neurotrophic factor (BDNF) for the treatment of Alzheimer's disease (AD) is designed. The BDNF‐TPN significantly enhances BDNF accumulation in the brain following intravenous injection, reduces apoptosis and neuroinflammation, thus promoting neuronal survival and ...
Lily Yi Li, Elliya Park, Chunsheng He, Azhar Z. Abbasi, Pei Zhi, Paul E. Fraser, Andrew M. Rauth, Jeffery T. Henderson, Xiao Yu Wu   +8 more
wiley   +1 more source

Single nucleotide polymorphisms as a prerequisite for autoantigens [PDF]

European Journal of Immunology, 2005
AbstractIt is still elusive why certain self proteins induce an autoimmune response. One immunological hypothesis is that only modified or altered self‐proteins may become a target. Thus, we asked whether such alterations may actually be genetic polymorphisms that can be revealed by analyzing sequence variability in the known human autoantigens. Indeed,
Sarah Luginbühl, Beda M. Stadler, Diana Arnold, Sara Frieden, Michael B. Stadler   +4 more
openaire   +3 more sources

Aggregation of Single Nucleotide Polymorphisms in a Human H5N1 Clade 2.2 Hemagglutinin [PDF]

, 2007
The evolution of H5N1 has attracted significant interest 1-4 due to linkages with avian 5,6 and human infections 7,8. The basic tenets of influenza genetics 9 attribute genetic drift to replication errors caused by a polymerase complex that lacks a ...
Abdelattar Arafa, Ahmed E. Nayel, Ahmed S. Abdelghani, Bruce R. Boynton, Ehab A. Ayoub, Emad M. Labib, Gregory A. Raczniak, Hala M. Esmat, Henry L. Niman, Jeffery Tjaden, Kenneth C. Earhart, Magdi D. Saad, Marshall R. Monteville, Mensah Agyen-Frempong, Mona M. Aly, Moustafa M. Mansour, Nasr El-Sayed, William K. Ampofo   +17 more
core   +2 more sources

Impact of IFN lambda 3/4 single nucleotide polymorphisms on the cytomegalovirus reactivation in autologous stem cell transplant patients [PDF]

, 2018
Cytomegalovirus (CMV) infection represents one of the main cause mortality after Stem Cell Transplantation. Recently, a protective effect of the T allele of rs12979860 IL28B Single Nucleotide Polymorphisms (SNPs) against CMV infection in the allogenic ...
Angeletti, S, Annibali, O, Avvisati, G, Cantonetti, M, Circhetta, E, Franceschini, L, Piccioni, L, Riva, E., Rizzo, E, Sarlo, C, Scagnolari, C, Statzu, M, Tirindelli, Mc, Tomarchio, V   +13 more
core   +1 more source

Harnessing Photo‐Energy Conversion in Nanomaterials for Precision Theranostics

Advanced Materials, EarlyView.
Harnessing photo‐energy conversion in nanomaterials enables precision theranostics through light‐driven mechanisms such as photoluminescence, photothermal, photoelectric, photoacoustic, photo‐triggered surface‐enhanced Raman scattering (SERS), and photodynamic processes. This review explores six fundamental principles of photo‐energy conversion, recent
Jingyu Shi, Yadi Fan, Qin Zhang, Yingying Huang, Mo Yang   +4 more
wiley   +1 more source