Results 201 to 210 of about 1,224,383 (281)

NARFL Knockout Triggers Ferroptosis‐Driven Vascular Endothelial Dysfunction

Advanced Science, EarlyView.
NARFL is vital for CIA and oxidative stress resistance. NARFL deletion in HPMEC cells, zebrafish, and mice is lethal and rescued by a Ferroptosis inhibitor. NARFL deficiency disrupted its interaction with CIA proteins, decreased aconitase activity, increased IRP1 activity, induced Fe overload, and led to ferroptosis and oxidative stress, resulting in ...
Hui Hu, Jing Luo, Li Yu, Daoxi Qi, Boyu Li, Yating Chen, Chen Wang, Xiaokang Zhang, Wenzheng Guo, Qiyong Lou, Gang Zhai, Yonglin Ruan, Jianfei Huang, Shengchi Shi, Zhan Yin, Fang Zheng   +15 more
wiley   +1 more source

Association between the <i>PPARGC1A</i> Gly482Ser (rs8192678) polymorphism and endurance and power athlete status: a systematic review and meta-analysis. [PDF]

Front Physiol
Su W, Yuan L, He Z, Ding F, Sun J, Xiong Y, Song X.   +6 more
europepmc   +1 more source

Allosteric Modulation of Pathological Ataxin‐3 Aggregation: A Path to Spinocerebellar Ataxia Type‐3 Therapies

Advanced Science, EarlyView.
This study uncovers a new allosteric site in the Josephin domain of ataxin‐3 targeted by the molecular tweezer CLR01, which modulates protein aggregation, improves synaptic function in neuronal cells, and delays motor dysfunction in animal models.
Alexandra Silva, Sara Duarte‐Silva, Pedro M. Martins, Beatriz Rodrigues, Débora Serrenho, Daniela Vilasboas‐Campos, Andreia Teixeira‐Castro, Julio Vieyto‐Nuñez, Joel Mieres‐Perez, Francisco Figueiredo, Martyna Podlasiak, Tatiana Van‐der‐Kellen, Joana Fraga, James Noble, Carter Lantz, Niki Sepanj, Daniela Monteiro‐Fernandes, Sara Guerreiro, Andreia Neves‐Carvalho, Joana Pereira‐Sousa, Frank‐Gerrit Klärner, Thomas Schrader, Joseph A. Loo, Annalisa Pastore, Elsa Sanchez‐Garcia, Gal Bitan, Ana Luísa Carvalho, Patrícia Maciel, Sandra Macedo‐Ribeiro   +28 more
wiley   +1 more source

TNFAIP3 Gene Polymorphisms and the Risk of Thrombocytopenia: A Cross-Sectional Study in Iranian Population. [PDF]

Health Sci Rep
Alizadeh Saadooni S, Eftekhar Z, Jalali Far MA, Saki N, Kydani GA, Karimpourian H, Aminasnafi A.   +6 more
europepmc   +1 more source

A Patient‐Derived Organoid Biobank of Adamantinomatous Craniopharyngioma as a Platform for Drug Discovery

Advanced Science, EarlyView.
This study successfully establishes adamantinomatous craniopharyngioma (ACP) patient‐derived organoids (PDOs) that preserve the histopathological and genetic features of the original tumors. Through drug sensitivity assays and subsequent mechanistic analyses, the study demonstrates that Ceritinib exerts its inhibitory effects on ACP PDO growth by ...
Huarong Zhang, Chaohu Wang, Jun Fan, Zexin Chen, Haoying Yu, Yawen Bai, Tingcheng Zhang, Qianchao Zhu, Yiwen Feng, Peirong Niu, Jiaqian Chen, Liping Yang, Xueying Li, Lei Yu, Songtao Qi, Yi Liu   +15 more
wiley   +1 more source

The interactions between major dietary patterns and rs320 polymorphism of LPL gene on cardiometabolic risk factors. [PDF]

Sci Rep
Safakar HY, Khayyatzadeh SS, Yazdanpanah Z, Mollahosseini M, Sheikhha MH, Mirzaei M, Fallahzadeh H, Mozaffari-Khosravi H.   +7 more
europepmc   +1 more source

Crystallization at Solvent Interfaces Enables Access to a Variety of Cocrystal Polymorphs and Hydrates

, 2018
Stefan J. Diez, Mark D. Eddleston, Mihails Arhangelskis, Marie Milbled, M. Müller, Andrew D. Bond, Dejan-Krešimir Buč̌ar, William Jones   +7 more
openalex   +1 more source

Polymorphism in the CAVI gene, salivary properties and dental caries

, 2020
Paula Piekoszewska‐Ziętek, Konrad Szymañski, Dorota Olczak‐Kowalczyk   +2 more
openalex   +1 more source

Polymorphism of fur coloration intensity in mammals [PDF]

, 2016
Yulia Zizda
openalex   +1 more source

Formation of Condition‐Dependent Alpha‐Synuclein Fibril Strain in Artificial Cerebrospinal Fluid

Advanced Science, EarlyView.
α‐synuclein aggregation in artificial cerebrospinal fluid (aCSF) leads to a distinct conformation with an electron density pocket motif found in aggregates from PD and MSA patients. Such fibrils has low stability outside the reaction conditions, hinting about the influence of cerebrospinal fluid components not only on the formation, but also on the ...
Rūta Sniečkutė, Darius Šulskis, Arūnė Jocytė, Urtė Venclovaitė, Rimgailė Tamulytė, Mantas Žiaunys, Vytautas Smirnovas, Andrius Sakalauskas   +7 more
wiley   +1 more source