Results 81 to 90 of about 727,358 (304)

Pharmacological effects of osimertinib on a chicken chorioallantoic membrane xenograft model with the EGFR exon‐19‐deleted advanced NSCLC mutation

open access: yesFEBS Open Bio, EarlyView.
Osimertinib reduces angiogenesis and PDL1 expression in in ovo tumors, transforming them into ‘cold tumors’ with lower immune activity. Anatomopathological and transcriptomic analyses highlight its therapeutic impact on tumor biology. This study underscores osimertinib's potential to reshape the tumor microenvironment and provides insights into its ...
David Barthélémy   +14 more
wiley   +1 more source

Characterisation of the role played by ELMO1, GPR141 and the intergenic polymorphism rs918980 in Fuchs' dystrophy in the Indian population

open access: yesFEBS Open Bio, EarlyView.
This study reports the upregulation of ELMO1 and GPR141 in human Fuchs' endothelial corneal dystrophy (FECD) corneal endothelium and ultraviolet A‐induced FECD mice model. A genetic association of an intergenic single nucleotide polymorphism rs918980 present between both genes is observed with FECD in the Indian population.
Susmita Sharma   +3 more
wiley   +1 more source

Interacciones entre mezclas de aceites de palma y palmiste interesterificados. II – Microscopía y Calorimetría Diferencial de Barrido (DSC)

open access: yesGrasas y Aceites, 2001
Palm oil (PO) and palm kernel oil (PKO) compositions (100/0, 80/20, 60/40, 50/50, 40/60, 20/80 and 0/100) were interesterified in laboratory scale under predetermined conditions (0.4% sodium metoxide, 20 minutes, 100ºC).
Renato Grimaldi   +3 more
doaj   +1 more source

Multilocus patterns of nucleotide variability and the demographic and selection history of drosophila melanogaster populations [PDF]

open access: yes, 2005
Uncertainty about the demographic history of populations can hamper genome-wide scans for selection based on population genetic models. To obtain a portrait of the effects of demographic history on genome variability patterns in Drosophila melanogaster ...
Andolfatto, Peter   +3 more
core   +1 more source

Possible role of human ribonuclease dicer in the regulation of R loops

open access: yesFEBS Open Bio, EarlyView.
R loops play an important role in regulating key cellular processes such as replication, transcription, centromere stabilization, or control of telomere length. However, the unscheduled accumulation of R loops can cause many diseases, including cancer, and neurodegenerative or inflammatory disorders. Interestingly, accumulating data indicate a possible
Klaudia Wojcik   +2 more
wiley   +1 more source

Second order conservative languages with a Maltsev polymorphism also have a majority polymorphism [PDF]

open access: yesarXiv, 2017
The paper proves that for any second order conservative constraint language with a Maltsev polymorphism there is a majority polymorphism. Moreover, the majority polymorphism can be defined by the Maltsev polymorphism.
arxiv  

Comparative study of adenosine 3′‐pyrophosphokinase domains of MuF polymorphic toxins

open access: yesFEBS Open Bio, EarlyView.
With the ultimate goal of understanding the association of toxin‐immunity modules to temperate phages, we characterized toxins from three prophages and examined cross‐protection from immunity proteins. The toxins exhibit adenosine 3′‐pyrophosphokinase activity and are toxic in Escherichia coli.
Eloïse M. Paulet   +6 more
wiley   +1 more source

Association study between the MDR1 gene and clinical characteristics in schizophrenia

open access: yesBrazilian Journal of Psychiatry, 2014
Objective: Schizophrenia is a complex psychiatric disorder, characterized by disturbed patterns of thought and affecting 0.3-2.0% of the world population.
Carlos A. Tovilla-Zárate   +8 more
doaj   +1 more source

Algebraic Polymorphisms [PDF]

open access: yesarXiv, 2007
In this paper we consider a special class of polymorphisms with invariant measure, - (cf.[1])- the algebraic polymorphisms of compact groups. A general polymorphism is -- by definition -- a many-valued map with invariant measure, and the conjugate operator of a polymorphism is a Markov operator (i.e., a positive operator on $L^2$ of norm 1 which ...
arxiv  

Development of SSR markers from Citrus clementina (Rutaceae) BAC end sequences and interspecific transferability In Citrus (P148) [PDF]

open access: yes, 2011
Microsatellite primers were developed from bacterial artificial chromosome (BAC) end sequences (BES) of Citrus clementina and their transferability and polymorphism tested in the genus Citrus for future anchorage of physical and genetic maps and ...
Navarro, Luis   +5 more
core  

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