Results 81 to 90 of about 1,178,111 (366)
Arthritis Care &Research, EarlyView.Objective The objective of this study was to evaluate and compare the risk of hepatotoxicity associated with the use of febuxostat and benzbromarone in patients with gout. Methods New users of febuxostat or benzbromarone with monitoring of liver function at least three times in a year after initiation of the study drugs were identified from an ...
Wenyan Sun +8 more
wiley +1 more source
A Simplification Method of Polymorphic Boolean Functions [PDF]
arXiv, 2017 Polymorphic circuits are a special kind of circuits which possess multiple build-in functions, and these functions are activated by environment parameters, like temperature, light and VDD. The behavior of a polymorphic circuit can be described by a polymorphic Boolean function.
arxiv
EGFR-TKI resistance due to BIM polymorphism can be circumvented in combination with HDAC inhibition.
Cancer Research, 2013 BIM (BCL2L11) is a BH3-only proapoptotic member of the Bcl-2 protein family. BIM upregulation is required for apoptosis induction by EGF receptor (EGFR) tyrosine kinase inhibitors (EGFR-TKI) in EGFR-mutant forms of non-small cell lung cancer (NSCLC ...
T. Nakagawa +10 more
semanticscholar +1 more source
Whole‐Blood RNA Sequencing Profiling of Patients With Rheumatoid Arthritis Treated With Tofacitinib
ACR Open Rheumatology, EarlyView.Objective Patients with rheumatoid arthritis (RA) often fail to respond to therapies, including JAK inhibitors (JAKi), and treatment allocation is made via a trial‐and‐error strategy. A comprehensive analysis of responses to JAKi, including tofacitinib, by RNA sequencing (RNAseq) would allow the discovery of transcriptomic markers with a two‐fold ...
Chiara Bellocchi +11 more
wiley +1 more source
Polymorphism of Amyloid Fibrils In Vivo.
Angewandte Chemie, 2016 Polymorphism is a wide-spread feature of amyloid-like fibrils formed in vitro, but it has so far remained unclear whether the fibrils formed within a patient are also affected by this phenomenon.
K. Annamalai +10 more
semanticscholar +1 more source
Advanced Engineering Materials, Volume 27, Issue 6, March 2025.The stability criteria affecting the formation of high‐entropy alloys, particularly focusing in supersaturated solid solutions produced by mechanical alloying, are analyzed. Criteria based on Hume–Rothery rules are distinguished from those derived from thermodynamic relations. The formers are generally applicable to mechanically alloyed samples.
Javier S. Blázquez +5 more
wiley +1 more source
Design Methods for Polymorphic Combinational Logic Circuits based on the Bi_Decomposition Approach [PDF]
arXiv, 2017 Polymorphic circuits are a special kind of digital logic components, which possess multiple build-in functions. In different environments, a polymorphic circuit would perform different functions. Evolutionary Algorithms, Binary Decision Diagrams (BDD) and the multiplex method have been adopted to design polymorphic circuits.
arxiv
Multi-objective optimization for targeted self-assembly among competing polymorphs [PDF]
Phys. Rev. X 15, 011075 (2025)Most approaches for designing self-assembled materials focus on the thermodynamic stability of a target structure or crystal polymorph. Yet in practice, the outcome of a self-assembly process is often controlled by kinetic pathways. Here we present an efficient machine learning-guided design algorithm to identify globally optimal interaction potentials
arxiv +1 more source
Meta-morphism: Exotic Polymorphism of Metamaterial Self-assembled by pyrene derivative [PDF]
arXiv, 2021 Polymorphism, which describes the occurrence of different lattice structures in a crystalline material, is a critical phenomenon in material science and condensed matter physics. It has emerged as a major focus for industry and regulatory agencies respectively.
arxiv
A common MUC5B promoter polymorphism and pulmonary fibrosis.
New England Journal of Medicine, 2011 BACKGROUND The mutations that have been implicated in pulmonary fibrosis account for only a small proportion of the population risk. METHODS Using a genomewide linkage scan, we detected linkage between idiopathic interstitial pneumonia and a 3.4-Mb ...
M. Seibold +28 more
semanticscholar +1 more source