Results 51 to 60 of about 853,491 (302)
Pharmacogenomics and Personalized Medicine, 2021 Hai-Jie Xing,1,*,2 Xiang-Dong Chen,3,* Hong-Xia Sun,4,* Yao-Zhang Dai,5,* Yao-Feng Han,6,* Hai-Bo Chen,7,* Feng Liu8,9,* 1Department of Otorhinolaryngology, Head and Neck Surgery, University of Chinese Academy of Sciences ...
Xing HJ +6 more
doaj
Phylogeographic evidence of crop neo-diversity in Sorghum : [Abstract W101] [PDF]
, 2009 We report here a study on sorghum, using a well characterized sample of diverse cultivars that we resequenced for portions of six genes possibly involved in grain quality variation.
Billot, Claire +9 more
core
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Frontiers in Behavioral Neuroscience, 2022 Methylphenidate (MPH) is the first-line drug for the treatment of children with attention-deficit hyperactivity disorder (ADHD); however, individual curative effects of MPH vary.
Jie Li +5 more
doaj +1 more source
Schaefer's theorem for graphs [PDF]
, 2015 Schaefer's theorem is a complexity classification result for so-called Boolean constraint satisfaction problems: it states that every Boolean constraint satisfaction problem is either contained in one out of six classes and can be solved in polynomial ...
Bodirsky, Manuel, Pinsker, Michael
core +2 more sources
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
Archives of Medical Science, 2019 Introduction The CYP450 complex participates in the metabolism of ifosfamide, an antineoplastic drug used to treat solid tumors. genes contain several single nucleotide polymorphisms (SNPs) that confer different activity towards the enzyme.
Luz María Torres Espindola +10 more
doaj +1 more source
Interleukin-18 gene promoter polymorphisms and recurrent spontaneous abortion [PDF]
Background: IL-18 is a multifunctional cytokine capable of inducing either Th1 or Th2 polarization depending on the immunologic milieu. IL-18 is detected at the materno-fetal interface very soon in early pregnancy.
امانی, داور +5 more
core +1 more source
Molecular Oncology, EarlyView.Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata +10 more
wiley +1 more source
Balkan Journal of Medical Genetics, 2022 Multiple second heart field (SHF) transcription factors are involved in cardiac development. In this article we evaluate the relationship between SHF transcription factor polymorphisms and congenital heart disease (CHD).
Wang E, Fan X, Nie Y, Zheng Z, Hu S
doaj +1 more source