Results 41 to 50 of about 249,399 (261)

The Association between TNF-alpha Gene Polymorphisms and Endometriosis in An Iranian Population [PDF]

International Journal of Fertility and Sterility, 2019
Background Tumor necrosis factor-alpha (TNF-α) is an important cytokine in acute inflammatory response to infective factors. Based on investigation in different populations, it is thought that this response increases in patients with endometrio- sis ...
Babak Babaabasi, Ali Ahani, Faegheh Sadeghi, Haniyeh Bashizade-Fakhar, Hamid Reza Khorram Khorshid   +4 more
doaj   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

Emotional dimension associated with the migratory experience of adult refugees and asylum seekers

Scientific Reports
This study explores the impact of the migratory process on the mental health of refugees and asylum seekers arriving in Spain. It examines the feelings and emotions associated with emigration, alongside its underlying causes. A mixed-methods approach was
María José Cáceres-Titos, Ana María Fernández-Araque, E. Begoña García-Navarro   +2 more
doaj   +1 more source

Lysyl oxidase (LOX)‐mediated remodeling of the extracellular matrix

FEBS Letters, EarlyView.
The lysyl oxidase (LOX) family of enzymes drives extracellular matrix remodeling by oxidizing collagen, elastin, and fibronectin, promoting covalent cross‐link formation. This activity regulates tissue architecture and mechanical properties, while its dysregulation contributes to fibrosis, cardiovascular disease, glaucoma, connective tissue disorders ...
Fernando Rodríguez‐Pascual, Marta Navarro‐Gutiérrez, Verónica Romero‐Albillo, Raquel Jiménez‐Sánchez   +3 more
wiley   +1 more source

Role of Toll-like receptors polymorphisms in the development of extremely severe COVID-19

Инфекция и иммунитет
COVID-19 is a respiratory disease caused by the SARS-CoV-2 virus that can proceed to acute respiratory distress syndrome (ARDS) and trigger immunopathological mechanisms that lead to excessive inflammation.
Lyudmila A. Ashchina, N. I. Baranova, O. A. Kulieva, A. I. Bolgova   +3 more
doaj   +1 more source

The Relevance of Regenerating Gene 1a Polymorphisms to Radiation Sensitivity and Survival of Nasopharyngeal Carcinoma Receiving Radiotherapy in a Southern Chinese Population

Pharmacogenomics and Personalized Medicine, 2021
Hai-Jie Xing,1,*,2 Xiang-Dong Chen,3,* Hong-Xia Sun,4,* Yao-Zhang Dai,5,* Yao-Feng Han,6,* Hai-Bo Chen,7,* Feng Liu8,9,* 1Department of Otorhinolaryngology, Head and Neck Surgery, University of Chinese Academy of Sciences ...
Xing HJ, Chen XD, Sun HX, Dai YZ, Han YF, Chen HB, Liu F   +6 more
doaj  

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Synaptosomal-Associated Protein 25 Gene Polymorphisms Affect Treatment Efficiency of Methylphenidate in Children With Attention-Deficit Hyperactivity Disorder: An fNIRS Study

Frontiers in Behavioral Neuroscience, 2022
Methylphenidate (MPH) is the first-line drug for the treatment of children with attention-deficit hyperactivity disorder (ADHD); however, individual curative effects of MPH vary.
Jie Li, Jie Li, Wen-Jie Yan, Yan Wu, Xin-Xin Tian, Yi-Wen Zhang   +5 more
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Effects of interacting networks of cardiovascular risk genes on the risk of type 2 diabetes mellitus (the CODAM study) [PDF]

, 2008
Background: Genetic dissection of complex diseases requires innovative approaches for identification of disease-predisposing genes. A well-known example of a human complex disease with a strong genetic component is Type 2 Diabetes Mellitus (T2DM ...
Paul MH Schiffers, Carla JH van der Kallen, Zhang, Jian, Kallen Carla JH, Schiffers, Paul M. H., van der Kallen, Carla J. H, Zhang Jian, Schiffers Paul MH, de Bruin Tjerk WA, van Greevenbroek Marleen MJ, Feskens Edith JM, Edith JM Feskens, Tjerk WA de Bruin, Jian Zhang, Marleen MJ van Greevenbroek, de Bruin, Tjerk W. A., Feskens, Edith J. M., van Greevenbroek, Marleen M.J., Greevenboek, M.M., van, Kallen, C.J., Bruin, T.W., Zhang, J., Feskens, E.J.M., Schiffers, P.M.   +23 more
core   +2 more sources