HLA Class-II Associated HIV Polymorphisms Predict Escape from CD4+ T Cell Responses. [PDF]
, 2015 Antiretroviral therapy, antibody and CD8+ T cell-mediated responses targeting human immunodeficiency virus-1 (HIV-1) exert selection pressure on the virus necessitating escape; however, the ability of CD4+ T cells to exert selective pressure remains ...
Allen, S +16 more
core +3 more sources
Pediatric Blood &Cancer, EarlyView.ABSTRACT Background This study investigated how neighborhood‐level social determinants of health (SDOH), including redlining and neurological risk, interact to influence cognitive outcomes in children treated for brain tumors (CTBT). Methods A retrospective chart review of 161 CTBT aged 5–17 was conducted.
Alannah R. Srsich +5 more
wiley +1 more source
The Association between TNF-alpha Gene Polymorphisms and Endometriosis in An Iranian Population [PDF]
International Journal of Fertility and Sterility, 2019 Background Tumor necrosis factor-alpha (TNF-α) is an important cytokine in acute inflammatory response to infective factors. Based on investigation in different populations, it is thought that this response increases in patients with endometrio- sis ...
Babak Babaabasi +4 more
doaj +1 more source
Genetic Polymorphisms of the Glucocorticoid Receptor and Interleukin-8 Receptor Genes are Related to Production Traits and Hair Coat Score in Crossbred Cattle [PDF]
, 2017 The objective of this thesis was to identify polymorphisms in the glucocorticoid receptor (GR) and interleukin-8 receptor (CXCR2) genes and to associate genotypes between the above mentioned polymorphisms and production traits in crossbred cattle.
Deaton, Avery
core +2 more sources
Vitamin D receptor gene polymorphisms and prognosis of breast cancer among African-American and Hispanic women. [PDF]
, 2013 BackgroundVitamin D plays a role in cancer development and acts through the vitamin D receptor (VDR). Although African-Americans have the lowest levels of serum vitamin D, there is a dearth of information on VDR gene polymorphisms and breast cancer among
Chen, Zujian +9 more
core +2 more sources
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Emotional dimension associated with the migratory experience of adult refugees and asylum seekers
Scientific ReportsThis study explores the impact of the migratory process on the mental health of refugees and asylum seekers arriving in Spain. It examines the feelings and emotions associated with emigration, alongside its underlying causes. A mixed-methods approach was
María José Cáceres-Titos +2 more
doaj +1 more source
War without weapons:constitution of healthy and pathological phenotypes associated with polymorphisms in genes involved in the maintenance of genome integrity [PDF]
, 2012 Capacity to repair DNA damage may vary significantly between individuals coming out as healthy on routine physical and laboratory examinations. This variance does not generally cause distress or disease unless in case that specific triggers are present ...
Khalil, Hilal S. +1 more
core +3 more sources
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
Role of Toll-like receptors polymorphisms in the development of extremely severe COVID-19
Инфекция и иммунитетCOVID-19 is a respiratory disease caused by the SARS-CoV-2 virus that can proceed to acute respiratory distress syndrome (ARDS) and trigger immunopathological mechanisms that lead to excessive inflammation.
Lyudmila A. Ashchina +3 more
doaj +1 more source