Results 31 to 40 of about 853,491 (302)
Evidence of complex involvement of serotonergic genes with restrictive and binge purge subtypes of anorexia nervosa [PDF]
, 2010 Peer ...
Blundell, John E. +5 more
core +1 more source
Allelic and genotype frequencies of major CYP2B6 polymorphisms in the Pakistani population
Molecular Genetics & Genomic Medicine, 2021 Background Cytochrome P450 (CYP2B6) is an important enzyme that metabolizes about 3.0% of therapeutic drugs. Drugs metabolized mainly by CYP2B6 include artemisinin, bupropion, cyclophosphamide, efavirenz, ketamine, and methadone.
Sagheer Ahmed +4 more
doaj +1 more source
Polymorphisms in the bradykinin B2 receptor gene and childhood asthma [PDF]
, 2001 Bradykinin has been suggested as one of the key mediators of bronchial asthma. Polymorphisms with a potential functional relevance have been described in the B2 bradykinin receptor gene.
Braun, A. +5 more
core +1 more source
A novel human glucocorticoid receptor SNP results in increased transactivation potential. [PDF]
, 2017 Glucocorticoids are one of the most widely used therapeutics in the treatment of a variety of inflammatory disorders. However, it is known that there are variable patient responses to glucocorticoid treatment; there are responders and non-responders, or ...
Cho, Kiho +5 more
core +3 more sources
Advanced Biomedical Research, 2016 Background: Variations in the hepatic lipase (HL) gene are the potential candidate for coronary artery disease (CAD) especially in type 2 diabetes mellitus (T2DM) in diverse populations. We assessed the association of -514C/T and -250G/A polymorphisms in
Ghorban Mohammadzadeh +3 more
doaj +1 more source
Aggregation of Single Nucleotide Polymorphisms in a Human H5N1 Clade 2.2 Hemagglutinin [PDF]
, 2007 The evolution of H5N1 has attracted significant interest 1-4 due to linkages with avian 5,6 and human infections 7,8. The basic tenets of influenza genetics 9 attribute genetic drift to replication errors caused by a polymerase complex that lacks a ...
Abdelattar Arafa +17 more
core +6 more sources
Pharmacogenetics of type 2 diabetes mellitus, the route toward tailored medicine [PDF]
, 2019 Type 2 diabetes mellitus (T2DM) is a chronic disease that has reached the levels of a global epidemic. In order to achieve optimal glucose control, it is often necessary to rely on combination therapy of multiple drugs or insulin because uncontrolled ...
Andreozzi, F, Mannino, Gc, Sesti, G
core +1 more source
Disappearing Polymorphs Revisited [PDF]
Angewandte Chemie International Edition, 2015 AbstractNearly twenty years ago, Dunitz and Bernstein described a selection of intriguing cases of polymorphs that disappear. The inability to obtain a crystal form that has previously been prepared is indeed a frustrating and potentially serious problem for solid‐state scientists.
Bucar, D, Lancaster, RW, Bernstein, J
openaire +3 more sources
Pediatric Blood &Cancer, EarlyView.ABSTRACT Treatment‐associated hepatotoxicity (TAH) is a common complication of pediatric acute lymphoblastic leukemia (ALL) treatment, but genetic risk factors remain poorly understood. We evaluated the SOD2 rs4880 variant in 544 children with ALL at Texas Children's Hospital. After adjusting for demographic and clinical covariates, the rs4880 C allele
Emily J. Mason +14 more
wiley +1 more source
Paraoxonase Gene Polymorphisms and Aortic Calcification
International Journal of Gerontology, 2010 Background: Aortic arch calcification is correlated with the extent of atherosclerosis and is a predictor of future cardiovascular risk. The paraoxonase (PON) gene can reduce the risk of atherosclerosis development.
Jinzi Wu +6 more
doaj +1 more source