Results 31 to 40 of about 13,231 (178)

COULD ANTI-SYNTHETASE SYNDROME BE A GOOD PREDICTOR FACTOR FOR INTERSTITIAL LUNG DISEASE? [PDF]

Romanian Journal of Rheumatology, 2017
Anti-synthetase syndrome (SAS) is an autoimmune inflammatory myopathy, whose immune profile is dominated by anti-RNA synthetase antibodies (ARS), with a specific clinical phenotype.
Sineta Cristina Firulescu, Paulina Lucia Ciurea, Cristina Dorina Parvanescu, Beatrice Andreea Chisalau, Andreea Lili Barbulescu, Cristina Criveanu, Adina Turcu-Stiolica, Roxana Edmee Mustafa, Florentin Ananu Vreju   +8 more
doaj   +1 more source

Atypical Presentation of Antisynthetase Syndrome: A Case Report

Medical Journal of Dr. D.Y. Patil Vidyapeeth, 2023
Antisynthetase syndrome is characterized by autoantibodies against one of many aminoacyl transfer RNA synthetases. The clinical features include interstitial lung disease (ILD), non-erosive arthritis, Raynaud’s phenomenon, myositis, unexplained fever ...
Shalesh Rohatgi, Prajwal Rao, Satish Nirhale, Pravin Naphade   +3 more
doaj   +1 more source

Impact of Six‐Month Monitoring Compared to Three‐Month Monitoring of Laboratories During Methotrexate Therapy

Arthritis Care &Research, EarlyView.
Objective To evaluate whether extending the American College of Rheumatology–recommended monitoring interval for complete blood count and liver function tests in patients receiving methotrexate (MTX) affects timely detection of medication‐related toxicity.
Spencer Simko, Ray Zhang, Sohini Mukherjee, Puneet Bajaj, Bonnie L. Bermas   +4 more
wiley   +1 more source

Polymyositis-Dermatomyositis and Interstitial Lung Disease in Pregnant Woman Successfully Treated with Cyclosporine and Tapered Steroid Therapy

Case Reports in Rheumatology, 2019
Polymyositis-dermatomyositis is extremely rare during pregnancy, and immunosuppressive therapy should be administered after carefully considering the effects on both the mother and fetus.
Saito Mayu, Sakiko Isojima, Yoko Miura, Shinichiro Nishimi, Mika Hatano, Takahiro Tokunaga, Ryo Takahashi, Keiko Koide, Yusuke Miwa   +8 more
doaj   +1 more source

Improved Detection of Myositis‐Specific Autoantibodies Using Luciferase Immunoprecipitation Systems Assay: Comparison With Line Blot and Conventional Immunoprecipitation

Arthritis &Rheumatology, EarlyView.
Objective Myositis‐specific autoantibodies guide the diagnosis and classification of idiopathic inflammatory myopathies, but current immunoassays vary in accuracy, particularly for autoantibodies associated with interstitial lung disease. To compare the performance of the luciferase immunoprecipitation systems (LIPS) assay with line blot and ...
Peter D. Burbelo, Iago Pinal‐Fernandez, Maria Casal‐Dominguez, Xin Tian, Shijinqiu Gao, Neha Gupta, Eric W. Robbins, John A. Chiorini, Christopher A. Mecoli, Lisa Christopher‐Stine, Livia Casciola‐Rosen, Andrew L. Mammen, Sonye K. Danoff, Anthony F. Suffredini, Julio A. Huapaya   +14 more
wiley   +1 more source

Polymyositis as a manifestation of chronic graft‐versus‐host disease after allo‐HSCT

Clinical Case Reports, 2018
Key Clinical Message Patients who received allogeneic haematopoietic stem cell transplantation (allo‐HSCT) may develop T cell‐mediated immunologic injury to muscles, recapitulating the characteristics of polymyositis clinically and pahtologically ...
Lijuan Meng, Suqiong Ji, Qiong Wang, Bitao Bu   +3 more
doaj   +1 more source

Acute heart failure and rhabdomyolysis: a clue for the diagnosis of polymyositis with cardiac involvement

Reumatismo, 2017
Polymyositis is an idiopathic inflammatory myopathy, characterized by proximal muscle weakness and sometimes extramuscular manifestations. We report the case of a 51-year-old male, with history of complete heart block, which required pacemaker ...
P. Pinto-Lopes, L. Carneiro-Leão, R. Morais, J. Pinheiro, A. Vieira Lopes, P. Bettencourt   +5 more
doaj   +1 more source

Interleukin‐2 Deprived State of Regulatory T cells and Their Recovery by Low‐Dose Interleukin‐2 in Patients With Inflammatory Myopathies

Arthritis &Rheumatology, EarlyView.
Objective Regeneration and expansion of Treg by low‐dose interleukin‐2 (IL‐2) therapy is considered a potential treatment strategy for a wide range of autoimmune diseases. To provide a pathophysiologically‐based rationale for low‐dose IL‐2 therapy, we investigated whether reversible defects in the Treg–IL‐2 axis emerge in inflammatory myopathies ...
Justus Ohmes, Luisa R. Monne, Sara Comdühr, Fynn Gerlach, Hanna Grasshoff, Alexander Dübbers, Antje Müller, Alexander Scheffold, Gabriela Riemekasten, Reza Akbarzadeh, Jens Y. Humrich   +10 more
wiley   +1 more source

Acute Exacerbation of Interstitial Lung Disease in Adult Patients With Idiopathic Inflammatory Myopathies: A Retrospective Case-Control Study

Frontiers in Medicine, 2020
Objective: This study aimed at clarifying the prevalence, risk factors, outcome, and outcome-related factors of acute exacerbation of interstitial lung disease (AE-ILD) in patients with idiopathic inflammatory myopathy (IIM).Methods: Data of IIM patients
Junyu Liang, Heng Cao, Yini Ke, Chuanyin Sun, Weiqian Chen, Jin Lin   +5 more
doaj   +1 more source

Outcomes in progressive pulmonary fibrosis in systemic autoimmune rheumatic diseases: real‐world data from the ILD‐PRO Registry

Arthritis &Rheumatology, Accepted Article.
Objective We evaluated baseline characteristics, treatment patterns, and outcomes in patients with systemic autoimmune rheumatic disease‐associated progressive pulmonary fibrosis (SARD‐PPF) and evaluated whether outcomes differed by SARD subtype. Methods The ILD‐PRO Registry is a prospective multicenter US registry of patients with PPF.
Sonali J Bracken, Jeremy M Weber, Megan L Neely, Aparna C Swaminathan, Scott M Palmer, Erin M Wilfong, Ann D Chauffe, Elizabeth R Volkmann   +7 more
wiley   +1 more source