Results 61 to 70 of about 27,152 (204)

The Role of C/EBP‐Homologous Protein in Idiopathic Inflammatory Myopathies

Journal of Cellular and Molecular Medicine, Volume 29, Issue 21, November 2025.
ABSTRACT The Idiopathic Inflammatory Myopathies (IIMs) are a group of autoimmune disorders characterised by persistent muscle inflammation and diverse clinical manifestations. Common symptoms include muscle weakness, myalgia, and elevated serum creatine kinase levels. Recent findings highlight the relevance of muscle fibre necrosis in IIMs.
Monica Sciacco, Patrizia Ciscato, Letizia Bertolasi, Maria Guttuso, Stefania Corti, Deborah Mattinzoli, Masami Ikeata, Giuseppe Castellano, Giacomo Pietro Comi, Simona Zanotti   +9 more
wiley   +1 more source

Safety of Percutaneous Muscle Biopsy: An Update Based on Over 2400 Procedures

Scandinavian Journal of Medicine &Science in Sports, Volume 35, Issue 11, November 2025.
ABSTRACT This study assessed the safety of percutaneous muscle biopsy by analyzing over 2400 procedures performed between 2007 and 2025 in healthy individuals and patients with chronic diseases. We retrospectively reviewed biopsy‐related adverse events among 1246 participants (471 healthy adults and 775 patients) to investigate whether health status or
Jhonnatan Vasconcelos Pereira Santos, Andresa Rossilho Casale, Rafael de Almeida Azevedo, Gabriela Borelli Garcia Eluf Politi, Samuel Katsuyuki Shinjo, Hamilton Roschel, Bruno Gualano   +6 more
wiley   +1 more source

Immune‐Mediated Necrotizing Myopathy Diagnosis and Flare in an Adolescent After COVID‐19 Vaccine

Clinical Case Reports, Volume 13, Issue 10, October 2025.
Muscle biopsy is histopathologically consistent with a diagnosis of immune‐mediated necrotizing myopathy. ABSTRACT We discuss a teenager who developed a rare pediatric autoimmune muscle disease after completing the primary COVID‐19 vaccine series, which flared shortly after COVID‐19 booster vaccination.
Patricia Hoffman, Ezra Chefitz, Cynthia Salvant, Daniel B. Horton   +3 more
wiley   +1 more source

An electrophysiological investigation of skeletal muscles in polymyositis Investigação eletrofisiológica de músculos esqueléticos na polimíosite

Arquivos de Neuro-Psiquiatria, 1976
An electrophysiological study has been made of the extensor digitorum brevis, thenar and hypothenar muscles in 25 patients with chronic and acute polymyositis.
R. E. P. Sica, Olga P. Sanz, Nidia Aguilera, A. Colombi   +3 more
doaj  

Characterization of Muscle Tissue Cell Diversity and Clinical Implications in Idiopathic Inflammatory Myopathy

Journal of Cachexia, Sarcopenia and Muscle, Volume 16, Issue 5, October 2025.
ABSTRACT Background Idiopathic inflammatory myopathies (IIMs) exhibit diverse cellular microenvironments in muscle tissues, yet the full spectrum of cell populations and changes remains unclear. This study aimed to characterize cellular heterogeneity, explore cell–cell interactions and assess the prognostic value of cell subtype abundances across IIM ...
Honglin Zhu, Yizhi Xiao, Shasha Xie, Qiming Meng, Ting Ding, Ting Huang, Di Liu, Sijia Liu, Xiaoli Zhang, Huali Zhang, Hui Luo   +10 more
wiley   +1 more source

Mechanical Stimulation Induces Yap Mediated OCTN2 Transcription to Enhance Carnitine Metabolism in Sarcopenia

Journal of Cachexia, Sarcopenia and Muscle, Volume 16, Issue 5, October 2025.
ABSTRACT Background Sarcopenia is a systemic skeletal muscle disease that seriously affects the health of the aged population. Exercise prevents sarcopenia, but the underlying mechanobiological and metabolic mechanisms need to be further investigated. Methods Carnitine and organic cation transporter 2 (OCTN2) levels were assessed in humans and animals ...
Yahong Lu, Yu Bai, Weiqing Li, Zhiguo Zhou, Heihuan Lai, Xingyu Hu, Tao Yang, Chendi Wang, Yitao Chen, Keping Gan, Kechi Li, Haiwei Ma, Lin Shen, Dengwei He   +13 more
wiley   +1 more source

Prevalência de manifestações clínico-laboratoriais e comorbidades na polimiosite segundo o gênero Prevalence of clinical and laboratory manifestations and comorbidities in polymyositis according to gender

Revista Brasileira de Reumatologia, 2011
OBJETIVO: Analisar a distribuição e a influência do gênero na polimiosite (PM), quanto às manifestações clínico-laboratoriais, evolução e comorbidades. MÉTODOS: Estudo de coorte retrospectivo, unicêntrico, em que foram avaliados 75 pacientes consecutivos
Fernando Henrique Carlos de Souza, Maurício Levy-Neto, Samuel Katsuyuki Shinjo   +2 more
doaj   +1 more source

Association of Omeprazole‐Related Myopathy With Drug–Drug and Drug–Gene Interactions Involving CYP2C19 and CYP3A4: A Nested Case–Control Study

Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, Volume 45, Issue 10, Page 654-666, October 2025.
ABSTRACT Background Omeprazole, a widely used proton pump inhibitor, has been associated with rare but serious adverse events such as myopathy. Previous research suggests that concurrent use of omeprazole with fluconazole, a potent cytochrome P450 (CYP) 2C19/3A4 inhibitor, may increase the risk of myopathy.
Eugene Jeong, Aditi Shendre, Yu Su, Xingyi Guo, Lang Li, You Chen   +5 more
wiley   +1 more source

Coexistência de hipotiroidismo e polimiosite Coexistence of hypothyroidism and polymyositis

Revista Brasileira de Reumatologia, 2003
Pacientes com hipotiroidismo freqüentemente apresentam sintomas músculo-esqueléticos e aumento de enzimas musculares, como a creatinaquinase (CK).
Maize Fernanda Bonim Singh, Sandra Regina M. Fernandes, Lilian Tereza Lavras Costallat, Manoel Barros Bértolo, Luciano de Souza Queiroz, Adil Muhib Samara   +5 more
doaj   +1 more source

Immune Characterization of a Vietnamese Cohort With Idiopathic Inflammatory Myopathies

Muscle &Nerve, Volume 72, Issue 3, Page 464-474, September 2025.
ABSTRACT Introduction/Aims Idiopathic inflammatory myopathies (IIMs) are classified into five subtypes that are associated with distinct groups of myositis‐specific antibodies (MSAs). Variations in the prevalence, genetic predisposition and clinical manifestations exist in patients with IIM from different ethnic backgrounds.
Yue‐Bei Luo, Maho Nakazawa, Nham Pham Thi Minh, Léo Heinon, Inger Nennesmo, Johan Rönnelid, Ingrid E. Lundberg, Thuy Nguyen Thi Phuong, Begum Horuluoglu   +8 more
wiley   +1 more source