Results 61 to 70 of about 13,568 (181)

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, Volume 20, Issue 8, Page 1913-1932, August 2026.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

COVID‐19 Vaccination Is Not Associated With the Development of Idiopathic Inflammatory Myositis in US Veterans

Arthritis Care &Research, Volume 78, Issue 8, Page 1078-1085, August 2026.
Objective Several case reports have proposed a potential association between COVID‐19 vaccination and the subsequent development of idiopathic inflammatory myositis (IIM). This study examined prior COVID‐19 vaccination in US veterans who developed new‐onset IIM compared to those without new‐onset IIM.
Caleb Hernández, Naomi Schlesinger, Jorge Rojas, Jessica A. Walsh, Tawnie J. Braaten, Gary A. Kunkel, Makoto Jones, Brian C Sauer, Julio Facelli, Grant W. Cannon, Dorota Lebiedz‐Odrobina   +10 more
wiley   +1 more source

Outcomes of Immune Check Point Inhibitor Use in US Veterans With Pre‐Existing Idiopathic Inflammatory Myopathies: Case Series and Literature Review

ACR Open Rheumatology, Volume 8, Issue 8, August 2026.
Objective Our objective was to identify and describe the clinical characteristics and outcomes in patients with pre‐existing idiopathic inflammatory myopathies (IIMs) in the Veterans Health Administration (VHA) treated with immune checkpoint inhibitors (ICIs). Methods All veterans receiving ICI infusions were identified.
Denis Krutko, Selene Rubino, Gary A. Kunkel, Jessica A. Walsh, Jorge Rojas, Brian C. Sauer, Shardool Patel, Grant W. Cannon, Tawnie J. Braaten   +8 more
wiley   +1 more source

Low Prevalence of Human T‐Cell Lymphotropic Virus Type 1 (HTLV‐1) in a Hospital Triage Population in Tehran During 2024–2025

Health Science Reports, Volume 9, Issue 8, August 2026.
ABSTRACT Background and Aims Human T‐cell lymphotropic virus type 1 (HTLV‐1) is a retrovirus that is associated to adult T‐cell leukemia/lymphoma (ATLL) and HTLV‐1–associated myelopathy/tropical spastic paraparesis (HAM/TSP) as two major diseases of the virus.
Arash Letafati, Shima Sadeghipour Marvi, Negar Asghari Hosori, Ghazale Molaverdi, Alireza Esfandiari, Nima Afshar Moghadam, Shabnam Siavoshi, Mehdi Norouzi, Sayed‐Hamidreza Mozhgani   +8 more
wiley   +1 more source

Haemostatic changes and bleeding with anti‐IL‐6 directed therapy in autoimmune diseases

British Journal of Pharmacology, Volume 183, Issue 15, Page 4111-4125, August 2026.
Abstract Anti‐IL‐6 directed therapy, especially tocilizumab (TCZ), is widely used for the treatment of autoimmune diseases such as rheumatoid arthritis, giant cell arteritis and systemic juvenile idiopathic arthritis. Next to being a master regulator of inflammation, IL‐6 also is an important regulator of haemostasis. Although generally well tolerated,
Charlotte D. C. C. van der Heijden, Loes C. Oskam, Lenny van Bon, Chantal P. Rovers   +3 more
wiley   +1 more source

Carbamoyl phosphate synthetase 1 deficiency manifested in an adult treated with prednisone for polymyositis, and cured by live-donor liver transplantation

Molecular Genetics and Metabolism Reports
Carbamoyl phosphate synthetase 1 (CPS1) deficiency (OMIM#237300) is a rare inherited disorder due to complete or partial lack of the CPS1 enzyme. Polymyositis is a relatively rare systemic inflammatory autoimmune disease.
Kazuhiro Yokota, Akira Ohtake, Taro Yamazaki, Takuma Tsuzuki-Wada, Megumi Saito-Tsuruoka, Takuya Fushimi, Kei Murayama, Yuji Akiyama, Toshihide Mimura   +8 more
doaj   +1 more source

Prevalência de manifestações clínico-laboratoriais e comorbidades na polimiosite segundo o gênero Prevalence of clinical and laboratory manifestations and comorbidities in polymyositis according to gender

Revista Brasileira de Reumatologia, 2011
OBJETIVO: Analisar a distribuição e a influência do gênero na polimiosite (PM), quanto às manifestações clínico-laboratoriais, evolução e comorbidades. MÉTODOS: Estudo de coorte retrospectivo, unicêntrico, em que foram avaliados 75 pacientes consecutivos
Fernando Henrique Carlos de Souza, Maurício Levy-Neto, Samuel Katsuyuki Shinjo   +2 more
doaj   +1 more source

POLYMYOSITIS FOLLOWING LEPTOSPIROSIS INFECTION: A CASE REPORT

Brazilian Journal of Infectious Diseases
Leptospirosis is a zoonosis transmitted by Leptospira, known for its immunomodulatory activity capable of stimulating immune activation and triggering autoimmune diseases, including polymyositis.
Bruna Kochhann Menezes, Amanda Sabrina Severgnini, Eduardo Cogo Motter, Larissa Pasqualotto Scopel, Natália Cousseau Grazziotin   +4 more
doaj   +1 more source

Overflow proteinuria as a manifestation of unrecognized polymyositis

International Medical Case Reports Journal, 2014
Hyun Ho Kim,1 Jae Young Kim,1 Sung Jun Kim,1,2 Eun Su Park,3 Seok Joon Shin,1,2 Kwi Young Kang,1,4 Yeon Sik Hong,1,4 Hye Eun Yoon1,21Department of Internal Medicine, College of Medicine, The Catholic University of Korea, 2Division of Nephrology ...
Kim HH, Kim JY, Kim SJ, Park ES, Shin SJ, Kang KY, Hong YS, Yoon HE   +7 more
doaj  

Coexistência de hipotiroidismo e polimiosite Coexistence of hypothyroidism and polymyositis

Revista Brasileira de Reumatologia, 2003
Pacientes com hipotiroidismo freqüentemente apresentam sintomas músculo-esqueléticos e aumento de enzimas musculares, como a creatinaquinase (CK).
Maize Fernanda Bonim Singh, Sandra Regina M. Fernandes, Lilian Tereza Lavras Costallat, Manoel Barros Bértolo, Luciano de Souza Queiroz, Adil Muhib Samara   +5 more
doaj   +1 more source