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Comparison of Polynucleotide and Polydeoxyribonucleotide in Dermatology: Molecular Mechanisms and Clinical Perspectives [PDF]

Pharmaceutics
Polynucleotide (PN) and polydeoxyribonucleotide (PDRN) are DNA-derived biopolymers increasingly recognized for their potential in dermatology. Despite their structural similarities, PN and PDRN exhibit distinct functions due to differences in polymer ...
Sung Tae Kim
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Combination of Hyaluronic Acid and Polynucleotides Injection for the Treatment of Cheilitis Simplex [PDF]

Clinical, Cosmetic and Investigational Dermatology
Kartika Ruchiatan, Yuri Yogya, Ilma Arifani, Reti Hindritiani, Diah Puspitosari, Trustia Rizqandaru, Srie Prihianti Gondokaryono, Pati Aji Achdiat Department of Dermatology and Venereology, Faculty of Medicine, Universitas Padjadjaran - Dr. Hasan Sadikin
Ruchiatan K, Yogya Y, Arifani I, Hindritiani R, Puspitosari D, Rizqandaru T, Gondokaryono SP, Achdiat PA   +7 more
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An Innovative Lip Boosting Technique Using Polynucleotides: “4-point Cannula Technique” [PDF]

Plastic and Reconstructive Surgery, Global Open
Summary:. The new concept in aesthetic medicine is heading toward regenerative medicine and the use of skin boosters in our practice, so the present case report aimed to evaluate the efficacy of injecting a polynucleotide into the lips for lip ...
Noury Adel, MSc
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Comprehensive rheological characterization of polynucleotide/BDDE-crosslinked hyaluronic acid blend for intra-articular viscosupplementation [PDF]

Scientific Reports
Viscosupplementation is a widely used treatment for osteoarthritis, aiming to restore the viscoelastic properties of synovial fluid and improve joint function. While hyaluronic acid (HA), BDDE-crosslinked hyaluronic acid (BDDE-HA), and polynucleotide (PN)
Hwanwoo Choi, Young Seok Song, Dongwhan Suh   +2 more
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Detecting polynucleotide motifs: Pentads, hexads, and beyond. [PDF]

PLoS Computational Biology
The structural diversity of nucleic acids extends far beyond the canonical Watson-Crick base pairing, encompassing higher-order motifs, such as triads, tetrads, pentads, hexads, heptads, and octads, which play critical roles in genome regulation and ...
Michal Zurkowski, Maja Marusic, Dorota Gudanis-Sobocinska, Marta Szachniuk   +3 more
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Polynucleotide HPT^TM-Based Hydrogels Exhibit Scavenging Activity Against Reactive Oxygen Species [PDF]

Antioxidants
This study investigates the scavenger activity of Polynucleotide High Purification Technology (PN HPTTM), alone or in combination with hyaluronic acid (PN HPTTM + HA) against oxidative stress induced by hydrogen peroxide (H2O2). Since oxidative stress is
Maria Teresa Colangelo, Silvana Belletti, Stefano Guizzardi, Carlo Galli   +3 more
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B-cell immunodeficiency associated with polynucleotide kinase 3′-phosphatase (PNKP) deficiency [PDF]

Journal of Allergy and Clinical Immunology: Global
Background: DNA repair is crucial for maintaining genomic integrity and plays a significant role in the immune system. Defects in DNA repair pathways are often associated with immunodeficiency, including B-cell defects, which are consistent with the need
Sanami Takada, MD, PhD, Tsubasa Okano, MD, PhD, Kay Tanita, MD, PhD, Kaima Tsukada, PhD, Masato Watanabe, MD, Atsushi Hijikata, PhD, Takuya Naruto, PhD, Tzu-Wen Yeh, PhD, Saki Kasuga, MD, PhD, Sadao Tokimasa, MD, PhD, Mariko Taniguchi-Ikeda, MD, PhD, Reina Ogata, MD, Azusa Ikeda, MD, PhD, Tomohide Goto, MD, PhD, Hitoshi Osaka, MD, PhD, Masatoshi Takagi, MD, PhD, Kohsuke Imai, MD, PhD, Tomohiro Morio, MD, PhD, Mirjam van der Burg, PhD, Mikio Shimada, PhD, Hirokazu Kanegane, MD, PhD   +20 more
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Sequential Bone Repair in Rabbit Sinus Lifts Using Bio-Oss and Hyaluronic Acid–Polynucleotide Gel (Regenfast) [PDF]

Journal of Functional Biomaterials
Background: A comprehensive investigation to associate the use of polynucleotides and hyaluronic acid with bovine bone in maxillary sinus lift procedures in rabbits has not been performed yet.
Nozomi Maniwa, Samuel Porfirio Xavier, Sergio Luis Scombatti de Souza, Erick Ricardo Silva, Daniele Botticelli, Kenzo Morinaga, Shunsuke Baba   +6 more
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Viscosupplementation in the Therapy for Osteoarthritic Knee

Applied Sciences, 2021
Osteoarthritis (OA) is a degenerative disease that is spreading worldwide due to an aging population. This is not simply a disease caused by worn out joints, but a complex disease accompanied by various mechanisms such as inflammatory reactions.
Junghyun Park, Hue Jung Park, Min Cheol Rho, Jin Joo   +3 more
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Phenanthridine–pyrene conjugates as fluorescent probes for DNA/RNA and an inactive mutant of dipeptidyl peptidase enzyme

Beilstein Journal of Organic Chemistry, 2023
Two novel conjugate molecules were designed: pyrene and phenanthridine-amino acid units with a different linker length between the aromatic fragments. Molecular modelling combined with spectrophotometric experiments revealed that in neutral and acidic ...
Josipa Matić, Tana Tandarić, Marijana Radić Stojković, Filip Šupljika, Zrinka Karačić, Ana Tomašić Paić, Lucija Horvat, Robert Vianello, Lidija-Marija Tumir   +8 more
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