Results 1 to 10 of about 93,488 (303)

Molecular dynamics study on the mechanism of polynucleotide encapsulation by chitosan

Scientific Reports, 2017
The safe and effective delivery of therapeutic genes into target cell interiors is of great importance in gene therapy. Chitosan has been extensively studied as a gene delivery carrier due to its good biocompatibility and biodegradability.
Jia-Wei Shen, Jiachen Li, Zhennan Zhao, Li Zhang, Guoteng Peng, Lijun Liang   +5 more
doaj   +2 more sources

An Innovative Lip Boosting Technique Using Polynucleotides: “4-point Cannula Technique” [PDF]

Plastic and Reconstructive Surgery, Global Open
Summary:. The new concept in aesthetic medicine is heading toward regenerative medicine and the use of skin boosters in our practice, so the present case report aimed to evaluate the efficacy of injecting a polynucleotide into the lips for lip ...
Noury Adel, MSc
doaj   +2 more sources

Polynucleotide phosphorylase: Not merely an RNase but a pivotal post-transcriptional regulator. [PDF]

PLoS Genetics, 2018
Almost 60 years ago, Severo Ochoa was awarded the Nobel Prize in Physiology or Medicine for his discovery of the enzymatic synthesis of RNA by polynucleotide phosphorylase (PNPase).
Todd A Cameron, Lisa M Matz, Nicholas R De Lay   +2 more
doaj   +2 more sources

Sequential Bone Repair in Rabbit Sinus Lifts Using Bio-Oss and Hyaluronic Acid–Polynucleotide Gel (Regenfast) [PDF]

Journal of Functional Biomaterials
Background: A comprehensive investigation to associate the use of polynucleotides and hyaluronic acid with bovine bone in maxillary sinus lift procedures in rabbits has not been performed yet.
Nozomi Maniwa, Samuel Porfirio Xavier, Sergio Luis Scombatti de Souza, Erick Ricardo Silva, Daniele Botticelli, Kenzo Morinaga, Shunsuke Baba   +6 more
doaj   +2 more sources

STUDIES ON POLYNUCLEOTIDES SYNTHESIZED BY POLYNUCLEOTIDE PHOSPHORYLASE [PDF]

Journal of Biological Chemistry, 1957
Leon Heppel, Priscilla J. Ortiz, Severo Ochoa   +2 more
  +7 more sources

Low molecular weight chitosan nanoparticulate system at low N:P ratio for nontoxic polynucleotide delivery

International Journal of Nanomedicine, 2012
Mohamad Alameh, Diogo DeJesus, Myriam Jean, Vincent Darras, Marc Thibault, Marc Lavertu, Michael D Buschmann, Abderrazzak MerzoukiInstitute of Biomedical Engineering, Department of Chemical Engineering, École Polytechnique, Montréal,
Alameh M, DeJesus D, Jean M, Darras V, Thibault M, Lavertu M, Buschmann MD, Merzouki A   +7 more
doaj   +2 more sources

BIOLOGIC PROPERTIES OF POLYNUCLEOTIDES. I. THE ANTI-COMPLEMENTARY ACTIVITY OF POLYNUCLEOTIDES* [PDF]

Journal of Clinical Investigation, 1963
Stanley Yachnin
openalex   +4 more sources

Viscosupplementation in the Therapy for Osteoarthritic Knee

Applied Sciences, 2021
Osteoarthritis (OA) is a degenerative disease that is spreading worldwide due to an aging population. This is not simply a disease caused by worn out joints, but a complex disease accompanied by various mechanisms such as inflammatory reactions.
Junghyun Park, Hue Jung Park, Min Cheol Rho, Jin Joo   +3 more
doaj   +1 more source

Phenanthridine–pyrene conjugates as fluorescent probes for DNA/RNA and an inactive mutant of dipeptidyl peptidase enzyme

Beilstein Journal of Organic Chemistry, 2023
Two novel conjugate molecules were designed: pyrene and phenanthridine-amino acid units with a different linker length between the aromatic fragments. Molecular modelling combined with spectrophotometric experiments revealed that in neutral and acidic ...
Josipa Matić, Tana Tandarić, Marijana Radić Stojković, Filip Šupljika, Zrinka Karačić, Ana Tomašić Paić, Lucija Horvat, Robert Vianello, Lidija-Marija Tumir   +8 more
doaj   +1 more source

Novel Tripodal Polyamine Tris-Pyrene: DNA/RNA Binding and Photodynamic Antiproliferative Activity

Pharmaceutics, 2023
A novel tri-pyrene polyamine (TAL3PYR) bearing net five positive charges at biorelevant conditions revealed strong intramolecular interactions in aqueous medium between pyrenes, characterised by pronounced excimer fluorescence.
Marta Jurković, Marijana Radić Stojković, Ksenija Božinović, Davor Nestić, Dragomira Majhen, Estefanía Delgado-Pinar, Mario Inclán, Enrique García-España, Ivo Piantanida   +8 more
doaj   +1 more source