Results 1 to 10 of about 32,057 (203)

Virus Replication as a Phenotypic Version of Polynucleotide Evolution [PDF]

open access: green, 2013
In this paper we revisit and adapt to viral evolution an approach based on the theory of branching process advanced by Demetrius, Schuster and Sigmund ("Polynucleotide evolution and branching processes", Bull. Math. Biol.
A. Eyre-Walker   +64 more
core   +2 more sources

Combination of Hyaluronic Acid and Polynucleotides Injection for the Treatment of Cheilitis Simplex

open access: greenClinical, Cosmetic and Investigational Dermatology
Kartika Ruchiatan, Yuri Yogya, Ilma Arifani, Reti Hindritiani, Diah Puspitosari, Trustia Rizqandaru, Srie Prihianti Gondokaryono, Pati Aji Achdiat Department of Dermatology and Venereology, Faculty of Medicine, Universitas Padjadjaran - Dr. Hasan Sadikin
Ruchiatan K   +7 more
doaj   +1 more source

Viscosupplementation in the Therapy for Osteoarthritic Knee

open access: yesApplied Sciences, 2021
Osteoarthritis (OA) is a degenerative disease that is spreading worldwide due to an aging population. This is not simply a disease caused by worn out joints, but a complex disease accompanied by various mechanisms such as inflammatory reactions.
Junghyun Park   +3 more
doaj   +1 more source

Phenanthridine–pyrene conjugates as fluorescent probes for DNA/RNA and an inactive mutant of dipeptidyl peptidase enzyme

open access: yesBeilstein Journal of Organic Chemistry, 2023
Two novel conjugate molecules were designed: pyrene and phenanthridine-amino acid units with a different linker length between the aromatic fragments. Molecular modelling combined with spectrophotometric experiments revealed that in neutral and acidic ...
Josipa Matić   +8 more
doaj   +1 more source

Novel Tripodal Polyamine Tris-Pyrene: DNA/RNA Binding and Photodynamic Antiproliferative Activity

open access: yesPharmaceutics, 2023
A novel tri-pyrene polyamine (TAL3PYR) bearing net five positive charges at biorelevant conditions revealed strong intramolecular interactions in aqueous medium between pyrenes, characterised by pronounced excimer fluorescence.
Marta Jurković   +8 more
doaj   +1 more source

The dynamics of polynucleotide chain consisting of two different homogeneous sequences, divided by interface [PDF]

open access: yesКомпьютерные исследования и моделирование, 2013
To research dynamics of inhomogeneous polynucleotide DNA chain the Y-model with no dissipation term was used. Basing on this model using numerical methods calculations were carried out, which have shown the behaviour of nonlinear conformational ...
Andrei Anatolevich Grinevich   +2 more
doaj   +1 more source

Polynucleotide phosphorylase protects against renal tubular injury via blocking mt-dsRNA-PKR-eIF2α axis

open access: yesNature Communications, 2023
Renal tubular atrophy is a hallmark of chronic kidney disease. The study by Zhu et al. reveals the protective role of tubular polynucleotide phosphorylase (PNPT1) against renal atrophy by blocking the leakage of mitochondrial dsRNAs into cytoplasm where ...
Yujie Zhu   +12 more
doaj   +1 more source

Development of an Interaction Assay between Single-Stranded Nucleic Acids Trapped with Silica Particles and Fluorescent Compounds

open access: yesJournal of Functional Biomaterials, 2012
Biopolymers are easily denatured by heating, a change in pH or chemical substances when they are immobilized on a substrate. To prevent denaturation of biopolymers, we developed a method to trap a polynucleotide on a substrate by hydrogen bonding using ...
R. Maeda, T. Isoda
doaj   +1 more source

Binding to the minor groove of the double-strand, tau protein prevents DNA from damage by peroxidation. [PDF]

open access: yesPLoS ONE, 2008
Tau, an important microtubule associated protein, has been found to bind to DNA, and to be localized in the nuclei of both neurons and some non-neuronal cells.
Yan Wei   +7 more
doaj   +1 more source

The Effect of Divalent Metal Ions on the Temperature Stability of Poly(I:C) Duplex

open access: yesJournal of Spectroscopy, 2020
The effect of divalent ions on the thermal stability of the double-stranded polynucleotide polyinosinic:polycytidylic acid (poly(I:C)) in a buffer solution (pH 7) was studied by UV absorption spectroscopy and thermal denaturation by measuring the ...
Evgeniya Usenko   +3 more
doaj   +1 more source

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