Results 91 to 100 of about 95,296 (292)

Role of the particle's stepping cycle in an asymmetric exclusion process: A model of mRNA translation [PDF]

, 2010
Messenger RNA translation is often studied by means of statistical-mechanical models based on the Asymmetric Simple Exclusion Process (ASEP), which considers hopping particles (the ribosomes) on a lattice (the polynucleotide chain).
Ciandrini, L., Romano, M. C., Stansfield, I.   +2 more
core   +3 more sources

Mystery and misery of locally‐delivered drug therapy in periodontics. Historical concepts and current state

Periodontology 2000, EarlyView.
Abstract The primary objective is to critically analyze approaches to local therapy for periodontal disease, particularly in light of its well‐established systemic implications. We specifically address common misconceptions and overestimations regarding the potential of local treatments in contrast to their actual clinical effectiveness.
Andrea Mombelli, Alkisti Zekeridou
wiley   +1 more source

Lack of Z-DNA Conformation in Mitomycin-Modified Polynucleotides Having Inverted Circular Dichroism [PDF]

, 1983
Poly(dG-dC)· poly(dG-dC) and Micrococcus lysodeikticus DNA were modified by exposure to reductively activated mitomycin C, an antitumor antibiotic. The resulting covalent drug-polynucleotide complexes displayed varying degrees of CD inversions, which are
Barton, Jacqueline K., Lafer, Eileen M., Magliozzo, Catherine C., Stollar, B. David, Tomasz, Maria, Tucker, David   +5 more
core   +1 more source

Hyaluronic acid: A novel approach in regenerative/reconstructive periodontal therapy?

Periodontology 2000, EarlyView.
Abstract Background Although hyaluronic acid (HA) has long been used for many medical applications, only in recent years has it gained greater popularity in the field of periodontics because of its biological effects during wound healing. Even today, most clinicians are not aware that more than one type of HA exists and that the extent of its ...
Andrea Pilloni, Yoshinori Shirakata, Lorenzo Marini, Darko Božić, Richard J. Miron, Roberto Rotundo, Andreas Stavropoulos, Anton Sculean   +7 more
wiley   +1 more source

Thermally Activated Stereoinversion in Benzotrithiophene‐Based Supramolecular Polymers with Water as the Effector

Angewandte Chemie, Volume 137, Issue 52, December 22, 2025.
The chiral benzotrithiophene derivative 1 self‐assembles into helical supramolecular polymers whose helicity changes with water content. High water content induces a reversible double stereomutation, while low water content yields a single, stable one. Computational studies show two monomer conformations leading to opposite helices.
Lucía López‐Gandul, Alberto Fernández‐Alarcón, Nicolás M. Casellas, Cristina Naranjo, Joaquín Calbo, Enrique Ortí, Miguel García‐Iglesias, Luis Sánchez   +7 more
wiley   +2 more sources

Kinetics of the template-directed oligomerization of guanosine 5'-phosphate-2-methylimidazolide: Effect of temperature on individual steps of reactionion [PDF]

Non-enzymatic, template-directed reactions have been proposed as models for prebiological polynucleotide synthesis. Chemically activated mononucleotides react in the presence of a polynucleotide, acting as the template in a Watson-Crick base-pairing ...
Alberas, D. J., Bernasconi, C. F., Kanavarioti, A.   +2 more
core   +1 more source

Crystal structure of human polynucleotide phosphorylase: insights into its domain function in RNA binding and degradation

Nucleic Acids Research, 2011
Human polynucleotide phosphorylase (hPNPase) is a 3′-to-5′ exoribonuclease that degrades specific mRNA and miRNA, and imports RNA into mitochondria, and thus regulates diverse physiological processes, including cellular senescence and homeostasis ...
C. Lin, Yi-Ting Wang, Wei-Zen Yang, Y. Hsiao, Hanna S. Yuan   +4 more
semanticscholar   +1 more source

Ulvan‐Based Electrospun Nanofibres From Water Solutions: Process Conditions and Characterisations

Journal of Applied Polymer Science, Volume 143, Issue 4, January 20, 2026.
Ulvan‐based electrospun nanofibres. ABSTRACT Recently, marine biopolymers have attracted considerable attention due to their high biocompatibility and biodegradability, making them ideal candidates in biomedical fields such as wound care, drug delivery, and tissue engineering.
Jacopo Paini, Federica Zaccheria, Gianluca Ottolina, Claudia Vineis, Erica Savino, Alessio Varesano   +5 more
wiley   +1 more source

Production of Homogeneous, Functional Zinc-Finger Arrays in High Yield With Two Chromatographic Steps

Bio-Protocol
Zinc-finger (ZF) arrays are compact, sequence-specific polynucleotide-binding domains, which have been used to target the delivery of diverse effector domains, enabling applications such as gene identification, localization, regulation, and editing.
Jingchang Liang, Maia Azubel, Guanqiao Wang, Yan Nie, Roger Kornberg, Andrew Beel, Pierre- Matteï   +6 more
doaj   +1 more source

Solvable models of neighbor-dependent nucleotide substitution processes

, 2005
We prove that a wide class of models of Markov neighbor-dependent substitution processes on the integer line is solvable. This class contains some models of nucleotide substitutions recently introduced and studied empirically by molecular biologists.
Bérard, Jean, Gouéré, Jean-Baptiste, Piau, Didier   +2 more
core   +3 more sources