Results 121 to 130 of about 93,488 (303)

Polynucleotide phosphorylase is implicated in homologous recombination and DNA repair in Escherichia coli

BMC Microbiology, 2017
Background Polynucleotide phosphorylase (PNPase, encoded by pnp) is generally thought of as an enzyme dedicated to RNA metabolism. The pleiotropic effects of PNPase deficiency is imputed to altered processing and turnover of mRNAs and small RNAs, which ...
Thomas Carzaniga, Giulia Sbarufatti, Federica Briani, Gianni Dehò   +3 more
doaj   +1 more source

Uncertainty‐Aware Visualization of Biomolecular Structures

Computer Graphics Forum, EarlyView.
A. Sterzik, C. Gillmann, M. Krone, K. Lawonn   +3 more
wiley   +1 more source

Small molecule inhibitors of mammalian glycosylation

Matrix Biology Plus, 2022
Glycans are one of the fundamental biopolymers encountered in living systems. Compared to polynucleotide and polypeptide biosynthesis, polysaccharide biosynthesis is a uniquely combinatorial process to which interdependent enzymes with seemingly broad ...
Karim Almahayni, Malte Spiekermann, Antonio Fiore, Guoqiang Yu, Kayvon Pedram, Leonhard Möckl   +5 more
doaj  

Nucleotide exchange reactions catalysed by ribonuclease and spleen phosphodiesterase. 2. Synthesis of polynucleotides [PDF]

, 1955
L. A. Heppel, Paul R. Whitfeld, Roy Markham   +2 more
openalex   +1 more source

Dual Modes of Interaction between XRCC4 and Polynucleotide Kinase/Phosphatase

Journal of Biological Chemistry, 2010
XRCC4 plays a crucial role in the nonhomologous end joining (NHEJ) pathway of DNA double-strand break repair acting as a scaffold protein that recruits other NHEJ proteins to double-strand breaks. Phosphorylation of XRCC4 by protein kinase CK2 promotes a
R. Mani, Yaping Yu, Shujuan Fang, Meiling Lu, M. Fanta, Angela E. Zolner, Nasser Tahbaz, D. Ramsden, D. Litchfield, S. Lees-Miller, M. Weinfeld   +10 more
semanticscholar   +1 more source

Single Molecule Statistics and the Polynucleotide Unzipping Transition

, 2001
We present an extensive theoretical investigation of the mechanical unzipping of double-stranded DNA under the influence of an applied force. In the limit of long polymers, there is a thermodynamic unzipping transition at a critical force value of order ...
A. Arneodo, A. B. Harris, A. Comtet, A. F. Oberhauser, A. Montanari, A. O. Parry, B. Derrida, B. Essevaz-Roulet, B. H. Zimm, B. Maier, C. Levinthal, C. Monthus, C.-K. Peng, D. Cule, D. Ertaş, D. K. Lubensky, D. K. Lubensky, D. Marenduzzo, D. Marenduzzo, D. Rhodes, D. S. Fisher, D. S. Fisher, D. Wirtz, David K. Lubensky, David R. Nelson, E. M. Blokhuis, F. Amblard, G. Bonnet, G. Radons, G. U. Lee, H. Clausen-Schaumann, H. Zhou, H. Zhou, I. Tinoco Jr., J. H. Gibbs, J. Liphardt, J. SantaLucia, J.-P. Bouchaud, J.-P. Bouchaud, K. Broderix, K. J. Breslauer, K. L. Sebastian, K. Visscher, L. H. Pope, L. Tskhovrebova, L.-H. Tang, M. D. Frank-Kamenetskii, M. E. Fisher, M. Opper, M. Peyrard, M. Peyrard, M. Rief, M. Rief, M. S. Z. Kellermayer, M. V. Feigel’man, N. Hatano, N. Hatano, P. Cluzel, P. le Doussal, P. Nelson, P. Pincus, R. Bar-Ziv, R. E. Thompson, R. Merkel, S. B. Smith, S. Cocco, S. Karlin, S. M. Bhattacharjee, S. V. Buldyrev, T. Hwa, T. Hwa, T. Strunz, T. T. Perkins, U. Bockelmann, U. Bockelmann, U. Gerland, X. Châtellier, Ya. G. Sinai   +77 more
core   +1 more source

Nol9 is a novel polynucleotide 5′-kinase involved in ribosomal RNA processing

EMBO Journal, 2010
In a cell, an enormous amount of energy is channelled into the biogenesis of ribosomal RNAs (rRNAs). In a multistep process involving a large variety of ribosomal and non‐ribosomal proteins, mature rRNAs are generated from a long polycistronic precursor.
Katrin Heindl, Javier Martinez
semanticscholar   +1 more source

Template-directed biopolymerization: tape-copying Turing machines

, 2012
DNA, RNA and proteins are among the most important macromolecules in a living cell. These molecules are polymerized by molecular machines. These natural nano-machines polymerize such macromolecules, adding one monomer at a time, using another linear ...
Chowdhury, Debashish, Sharma, Ajeet K.
core   +1 more source

Genetic Structures and Conditions of their Expression, which Allow Receiving Native Recombinant Proteins with High Output [PDF]

International Journal of Biomedicine, 2012
We investigated the possibility of obtaining native recombinant amyloidogenic proteins by creating genetic constructs encoding fusion proteins of target proteins with Super Folder Green Fluorescent Protein (sfGFP).
Michael M. Shavlovsky, PhD, ScD¹, Irina V. Morozova¹, Dmitry S. Polyakov, PhD¹, Tatyana D. Aleynikova, PhD¹, Anna M. Kern², Natalya A. Grudinina, PhD¹, Kirill V. Solovyov, PhD¹   +6 more
doaj  

DNA repair deficiency in neuropathogenesis: when all roads lead to mitochondria

Translational Neurodegeneration, 2019
Mutations in DNA repair enzymes can cause two neurological clinical manifestations: a developmental impairment and a degenerative disease. Polynucleotide kinase 3′-phosphatase (PNKP) is an enzyme that is actively involved in DNA repair in both single and
Luis Bermúdez-Guzmán, Alejandro Leal
doaj   +1 more source