Results 181 to 190 of about 48,872 (218)
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Model for the elongation of polynucleotide chains by polynucleotide phosphorylase
Journal of Molecular Biology, 1970Abstract The experiments described in this paper were designed to elucidate the mechanism of elongation of a polynucleotide chain catalysed by polynucleotide phosphorylase. The problem has been approached in three different ways, essentially: (1) examination of the size distribution of the end products isolated during the course of the reaction; (2 ...
M. Grunberg-Manago +2 more
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Biochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis, 1966
Abstract Methylation of guanosine 5′-phosphate under suitable conditions gives 1-methylguanylic acid. This was converted into the pyrophosphate which was then polymerised using polynucleotide phosphorylase from Escherichia coli. Some physical properties of poly N 1 - methylguanylic acid and the formation of a stable organised structure ...
F. Pochon, A.M. Michelson
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Abstract Methylation of guanosine 5′-phosphate under suitable conditions gives 1-methylguanylic acid. This was converted into the pyrophosphate which was then polymerised using polynucleotide phosphorylase from Escherichia coli. Some physical properties of poly N 1 - methylguanylic acid and the formation of a stable organised structure ...
F. Pochon, A.M. Michelson
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Biologic Properties of Polynucleotides. II. The Anticoagulant Properties of Polynucleotides
Blood, 1964Abstract Polyinosinic and polyguanylic acids have been found to possess anticoagulant properties. Other synthetic homoribopolynucleotides, as well as naturally occurring RNAs and DNAs are devoid of such properties. Polyinosinic acid will prolong the silicone recalcification time, Quick one-stage prothrombin time, and Russel Viper Venom ...
Stanley Yachnin, Stanley Yachnin
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Polarography of polynucleotides
Journal of Electroanalytical Chemistry and Interfacial Electrochemistry, 1979Abstract It has been shown that the thermally labile double-stranded polyribonucleotides poly(adenylic acid) · poly(uridylic acid) and poly(cytidylic acid) · poly(inosinic acid) produce differential pulse polarographic (DPP) peaks analogous to the DPP peak II of double-stranded deoxyribonucleic acid.
Emil Paleček, František Jelen
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Synthetic Analogues of Polynucleotides
Nature, 1968ANALOGUES of purines and pyrimidines have been used as antimetabolites1. Some of these have been converted into their nucleosides or nucleotides which also act as antimetabolites2. Analogues of nucleosides in which D-ribose or 2-deoxy-D-ribose is replaced by another carbohydrate or carbohydrate analogue have also been extensively studied2.
A. S. Jones, M. H. Halford
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Alkylation of Synthetic Polynucleotides
Science, 1964The synthetic polynucleotides may be used as models for the effects of alkylating agents on nucleic acid. Alkylation of polyadenylic acid with methyl methanesulfonate yields a polymer methylated in the one-position of adenine. This alteration in structure produces marked changes in physical properties and decreases the capacity to code for polylysine ...
David B. Ludlum +2 more
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Journal of Molecular Biology, 1965
A ribopolynucleotide containing the repeating trinucleotide sequence, adenylyl-adenylyl-guanylate (poly AAG) has been shown to direct the synthesis of polyly-sine, polyarginine and polyglutamate in the in vitro amino acid incorporation system. In experiments on the stimulation of the binding of [ 14 C]aminoacyl-sRNA to ribosomes the following results
D.S. Jones +5 more
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A ribopolynucleotide containing the repeating trinucleotide sequence, adenylyl-adenylyl-guanylate (poly AAG) has been shown to direct the synthesis of polyly-sine, polyarginine and polyglutamate in the in vitro amino acid incorporation system. In experiments on the stimulation of the binding of [ 14 C]aminoacyl-sRNA to ribosomes the following results
D.S. Jones +5 more
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Biochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis, 1970
Abstract 8-Bromoguanosine 5′-diphosphate, 8-oxoguanosine 5′-diphosphate, 6-methylcytidine 5′-diphosphate and 2,6-quinazoline dione 1′-ribosyl 5′-diphosphate are inactive as substrates for homopolymer synthesis with polynucleotide phosphorylase. They inhibit polymerization and exchange but not phosphorolysis.
A.M. Michelson, C. Monny, A.M. Kapuler
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Abstract 8-Bromoguanosine 5′-diphosphate, 8-oxoguanosine 5′-diphosphate, 6-methylcytidine 5′-diphosphate and 2,6-quinazoline dione 1′-ribosyl 5′-diphosphate are inactive as substrates for homopolymer synthesis with polynucleotide phosphorylase. They inhibit polymerization and exchange but not phosphorolysis.
A.M. Michelson, C. Monny, A.M. Kapuler
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The interaction of polynucleotides with cations
Biochimica et Biophysica Acta, 1959Abstract The interaction with divalent cations of the synthetic polynucleotides, polyadenylic acid and polyuridylic acid, has been studied by conductiometric titration. It is shown that further binding of divalent cation by polynucleotide ceases when one equivalent of cation has been added per mole of polymer phosphate, and that the titration curve ...
Sylvia Huang, Gary Felsenfeld
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Chemical Synthesis of Polynucleotides
Angewandte Chemie International Edition in English, 1972AbstractCurrent methodology for the chemical synthesis of short chains (up to about twenty nucleotide units) of deoxyribopolynucleotides is reviewed.
P. J. Cashion +3 more
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