Results 11 to 20 of about 95,296 (292)

Virus Replication as a Phenotypic Version of Polynucleotide Evolution [PDF]

, 2013
In this paper we revisit and adapt to viral evolution an approach based on the theory of branching process advanced by Demetrius, Schuster and Sigmund ("Polynucleotide evolution and branching processes", Bull. Math. Biol.
A. Eyre-Walker, A. Kowald, A. Timm, C. Escarmís, C. J. Thompson, C. Meyer, C. O. Wilke, C. O. Wilke, D. A. Steinhauer, D. R. Rokyta, Diogo Castro, E. Domingo, E. Domingo, E. Lázaro, F. Antoneli, F. Antoneli, F. Gantmacher, Fernando Antoneli, Francisco Bosco, H. A. Orr, H. W. Watson, I. Leuthäusser, J. A. Capitán, J. A. Cuesta, J. A. Cuesta, J. Aguirre, J. Aguirre, J. H. Wilkinson, J. Hermisson, J. J. Bull, J. J. Bull, J. J. Bull, J. Swetina, K. B. Athreya, K. Dietz, L. Demetrius, L. Demetrius, Luiz Mario Janini, M. Delbrück, M. Eigen, M. Eigen, M. Imhof, M. Jiřina, M. Kimmel, M. Parera, M. Ziehe, P. Carrasco, P. D. Keightley, P. Domingo-Calap, P. Jagers, R. Forster, R. M. Gray, R. Miralles, R. Sanjuán, S. C. Manrubia, S. Crotty, S. F. Elena, S. F. Elena, S. Ojosnegros, S. Ojosnegros, T. G. Kurtz, T. Harris, U. Grenander, W. Feller, Y. Zhu   +64 more
core   +2 more sources

Defects in Polynucleotide phosphorylase impairs virulence in Escherichia coli O157:H7 [PDF]

Frontiers in Microbiology, 2015
Polynucleotide phosphorylase (PNPase) is reported to regulate virulence in Salmonella, Yersinia spp. and Campylobacter jejuni, yet its role in Escherichia coli O157:H7 has not been investigated. To gain insights into its roles in E.
Jia eHu, Jia eHu, Meijun eZhu
doaj   +2 more sources

Role of polynucleotide kinase/phosphatase in mitochondrial DNA repair [PDF]

Nucleic Acids Research, 2011
Mutations in mitochondrial DNA (mtDNA) are implicated in a broad range of human diseases and in aging. Compared to nuclear DNA, mtDNA is more highly exposed to oxidative damage due to its proximity to the respiratory chain and the lack of protection ...
Nasser Tahbaz, Sudip Subedi, M. Weinfeld
semanticscholar   +2 more sources

Low molecular weight chitosan nanoparticulate system at low N:P ratio for nontoxic polynucleotide delivery

International Journal of Nanomedicine, 2012
Mohamad Alameh, Diogo DeJesus, Myriam Jean, Vincent Darras, Marc Thibault, Marc Lavertu, Michael D Buschmann, Abderrazzak MerzoukiInstitute of Biomedical Engineering, Department of Chemical Engineering, École Polytechnique, Montréal,
Alameh M, DeJesus D, Jean M, Darras V, Thibault M, Lavertu M, Buschmann MD, Merzouki A   +7 more
doaj   +2 more sources

Pseudomonas aeruginosa Polynucleotide Phosphorylase Contributes to Ciprofloxacin Resistance by Regulating PrtR [PDF]

Frontiers in Microbiology, 2019
Pseudomonas aeruginosa is an opportunistic bacterial pathogen that causes various acute and chronic infections. It is intrinsically resistant to a variety of antibiotics. However, production of pyocins during SOS response sensitizes P.
Zheng Fan, Hao Chen, Mei Li, Xiaolei Pan, Weixin Fu, Huan Ren, Ronghao Chen, Fang Bai, Yongxin Jin, Zhihui Cheng, Shouguang Jin, Weihui Wu   +11 more
doaj   +2 more sources

Viscosupplementation in the Therapy for Osteoarthritic Knee

Applied Sciences, 2021
Osteoarthritis (OA) is a degenerative disease that is spreading worldwide due to an aging population. This is not simply a disease caused by worn out joints, but a complex disease accompanied by various mechanisms such as inflammatory reactions.
Junghyun Park, Hue Jung Park, Min Cheol Rho, Jin Joo   +3 more
doaj   +1 more source

Efficacy of Polynucleotide-Based Therapy in Atopic Dermatitis Management. [PDF]

J Cosmet Dermatol
ABSTRACT Background Atopic dermatitis (AD) is a chronic inflammatory skin disease characterized by persistent itching, dryness, redness, and recurrent eczematous lesions, significantly impacting patients' quality of life and psychological well‐being.
Bae K, Cho Y, Soo K, Lee J, Park Y, Hyun Y, Kim JH, Yi K.   +7 more
europepmc   +2 more sources

Phenanthridine–pyrene conjugates as fluorescent probes for DNA/RNA and an inactive mutant of dipeptidyl peptidase enzyme

Beilstein Journal of Organic Chemistry, 2023
Two novel conjugate molecules were designed: pyrene and phenanthridine-amino acid units with a different linker length between the aromatic fragments. Molecular modelling combined with spectrophotometric experiments revealed that in neutral and acidic ...
Josipa Matić, Tana Tandarić, Marijana Radić Stojković, Filip Šupljika, Zrinka Karačić, Ana Tomašić Paić, Lucija Horvat, Robert Vianello, Lidija-Marija Tumir   +8 more
doaj   +1 more source

Novel Tripodal Polyamine Tris-Pyrene: DNA/RNA Binding and Photodynamic Antiproliferative Activity

Pharmaceutics, 2023
A novel tri-pyrene polyamine (TAL3PYR) bearing net five positive charges at biorelevant conditions revealed strong intramolecular interactions in aqueous medium between pyrenes, characterised by pronounced excimer fluorescence.
Marta Jurković, Marijana Radić Stojković, Ksenija Božinović, Davor Nestić, Dragomira Majhen, Estefanía Delgado-Pinar, Mario Inclán, Enrique García-España, Ivo Piantanida   +8 more
doaj   +1 more source

Sequence dependent phase separation of protein-polynucleotide mixtures elucidated using molecular simulations

Nucleic Acids Research, 2020
Ribonucleoprotein (RNP) granules are membraneless organelles (MLOs), which majorly consist of RNA and RNA-binding proteins and are formed via liquid–liquid phase separation (LLPS).
R. M. Regy, G. Dignon, Wenwei Zheng, Young C. Kim, J. Mittal   +4 more
semanticscholar   +1 more source