Results 11 to 20 of about 65,968 (266)

Molecular dynamics study on the mechanism of polynucleotide encapsulation by chitosan

Scientific Reports, 2017
The safe and effective delivery of therapeutic genes into target cell interiors is of great importance in gene therapy. Chitosan has been extensively studied as a gene delivery carrier due to its good biocompatibility and biodegradability.
Jia-Wei Shen, Jiachen Li, Zhennan Zhao, Li Zhang, Guoteng Peng, Lijun Liang   +5 more
doaj   +2 more sources

Polynucleotide phosphorylase: Not merely an RNase but a pivotal post-transcriptional regulator. [PDF]

PLoS Genetics, 2018
Almost 60 years ago, Severo Ochoa was awarded the Nobel Prize in Physiology or Medicine for his discovery of the enzymatic synthesis of RNA by polynucleotide phosphorylase (PNPase).
Todd A Cameron, Lisa M Matz, Nicholas R De Lay   +2 more
doaj   +2 more sources

STUDIES ON POLYNUCLEOTIDES SYNTHESIZED BY POLYNUCLEOTIDE PHOSPHORYLASE [PDF]

Journal of Biological Chemistry, 1957
Leon Heppel, Priscilla J. Ortiz, Severo Ochoa   +2 more
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Low molecular weight chitosan nanoparticulate system at low N:P ratio for nontoxic polynucleotide delivery

International Journal of Nanomedicine, 2012
Mohamad Alameh, Diogo DeJesus, Myriam Jean, Vincent Darras, Marc Thibault, Marc Lavertu, Michael D Buschmann, Abderrazzak MerzoukiInstitute of Biomedical Engineering, Department of Chemical Engineering, École Polytechnique, Montréal,
Alameh M, DeJesus D, Jean M, Darras V, Thibault M, Lavertu M, Buschmann MD, Merzouki A   +7 more
doaj   +2 more sources

BIOLOGIC PROPERTIES OF POLYNUCLEOTIDES. I. THE ANTI-COMPLEMENTARY ACTIVITY OF POLYNUCLEOTIDES* [PDF]

Journal of Clinical Investigation, 1963
Stanley Yachnin
openalex   +4 more sources

Sequence dependent phase separation of protein-polynucleotide mixtures elucidated using molecular simulations

Nucleic Acids Research, 2020
Ribonucleoprotein (RNP) granules are membraneless organelles (MLOs), which majorly consist of RNA and RNA-binding proteins and are formed via liquid–liquid phase separation (LLPS).
R. M. Regy, G. Dignon, Wenwei Zheng, Young C. Kim, J. Mittal   +4 more
semanticscholar   +1 more source

Streptomyces RNases – Function and impact on antibiotic synthesis

Frontiers in Microbiology, 2023
Streptomyces are soil dwelling bacteria that are notable for their ability to sporulate and to produce antibiotics and other secondary metabolites. Antibiotic biosynthesis is controlled by a variety of complex regulatory networks, involving activators ...
George H. Jones
doaj   +1 more source

The Effect of Divalent Metal Ions on the Temperature Stability of Poly(I:C) Duplex

Journal of Spectroscopy, 2020
The effect of divalent ions on the thermal stability of the double-stranded polynucleotide polyinosinic:polycytidylic acid (poly(I:C)) in a buffer solution (pH 7) was studied by UV absorption spectroscopy and thermal denaturation by measuring the ...
Evgeniya Usenko, Vladimir Valeev, Alexander Glamazda, Victor Karachevtsev   +3 more
doaj   +1 more source

Nonlinear waves in the DNA molecules containing a boundary between two homogeneous regions [PDF]

Компьютерные исследования и моделирование, 2009
Propagation of nonlinear conformational waves through the boundary dividing the double polynucleotide chain into two different homogeneous regions is investigated.
L. V. Yakushevich, A. V. Savin, L. I. Manevitch   +2 more
doaj   +1 more source

Label-Free Detection of T4 Polynucleotide Kinase Activity and Inhibition via Malachite Green Aptamer Generated from Ligation-Triggered Transcription

Biosensors, 2023
Polynucleotide kinase (PNK) is a key enzyme that is necessary for ligation-based DNA repair. The activity assay and inhibitor screening for PNK may contribute to the prediction and improvement of tumor treatment sensitivity, respectively.
Jingyi Si, Wei Zhou, Ying Fang, Da Zhou, Yifan Gao, Qunyan Yao, Xizhong Shen, Changfeng Zhu   +7 more
doaj   +1 more source